Zobrazeno 61 - 70
of 89
pro vyhledávání: '"Matthew R. Sarkisian"'
Autor:
Pasko Rakic, Matthew R. Sarkisian, Kazue Hashimoto-Torii, Hongbo Chi, Richard A. Flavell, Masaaki Torii, Fumihiko Nakamura, Christopher M. Bartley
Publikováno v:
Neuron. 52(5)
SummaryPeriventricular heterotopia (PVH) is a congenital malformation of human cerebral cortex frequently associated with Filamin-A (FLN-A) mutations but the pathogenetic mechanisms remain unclear. Here, we show that the MEKK4 (MAP3K4) pathway is inv
Publikováno v:
Developmental neuroscience. 29(1-2)
The dentate gyrus is a site of continual neurogenesis in the postnatal mammalian brain. Here we investigated postnatal neurogenesis in the citron kinase (citron-K) null-mutant rat (flathead). The flathead rat has substantial deficits in embryonic neu
Autor:
Matthew R. Sarkisian, Loic P. Deleyrolle, George Ugartemendia, Lan Hoang-Minh, Brent A. Reynolds, Susan L. Semple-Rowland, Joshua J. Breunig
Publikováno v:
Neuro-Oncology. 16:v42-v42
Despite recent findings that cilia transduce diverse signaling pathways affecting cell proliferation, migration and survival, little is known about the influence of cilia or cilia-associated proteins in glioblastoma multiforme (GBM). We recently show
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(10)
Neural tube defects (NTDs) are prevalent human birth defects. Mitogen-activated protein kinases (MAPKs), such as c-Jun N-terminal kinase (JNK), are implicated in facilitating neural tube closure, yet upstream regulators remain to be identified. Here,
Autor:
Matthew R. Sarkisian
Publikováno v:
Epilepsybehavior : EB. 2(3)
A diversity of animal models are available for the study of epilepsy and these models have a proven history in advancing our understanding of basic mechanisms underlying epileptogenesis and have been instrumental in the screening of novel antiepilept
Cytokinesis is an essential step in neurogenesis, yet the mechanisms that control cytokinesis in the developing CNS are not well understood. The flathead ( fh) mutation in rat results in cytokinesis failure in neural progenitors followed by apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb65f1a27f1192185dc6661da824e5f6
https://europepmc.org/articles/PMC6757530/
https://europepmc.org/articles/PMC6757530/
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991). 11(8)
One approach to defining mechanisms essential to neocortical development is to analyze the phenotype of novel spontaneous mutations that dramatically affect the generation and differentiation of different neocortical neurons. Previously we have shown
Autor:
Gregory L. Holmes, Matthew R. Sarkisian, Zhiqiang Liu, Diosely C. Silveira, P. Tandon, Y. Yang, L.-T Huang, Carl E. Stafstrom
Publikováno v:
Neuroscience. 92(4)
It is well documented that prolonged seizures (status epilepticus) can cause neuronal injury and result in synaptic reorganization in certain brain regions. However, the effect of recurrent, relatively short seizures in young animals on subsequent br
Publikováno v:
Neuroscience letters. 251(1)
A recently discovered, spontaneous, autosomal recessive mutation in rats, flathead (fh), results in greatly reduced brain growth beginning in late fetal development. In this study we have mapped the fh mutation by determining the pattern of segregati
Autor:
Yili Yang, Matthew R. Sarkisian, Pushpa Tandon, Zhao Liu, Gregory L. Holmes, Carl E. Stafstrom
Publikováno v:
Brain research. Developmental brain research. 107(2)
Prolonged seizures in the adult brain causes neuronal loss in the hippocampus and aberrant growth (sprouting) of granule cell axons (mossy fibers) in the supragranular zone of the fascia dentata and stratum infrapyramidale of CA3. There is considerab