Zobrazeno 31 - 40
of 89
pro vyhledávání: '"Matthew R. Sarkisian"'
Autor:
Matthew R. Sarkisian, Loic P. Deleyrolle, Brent A. Reynolds, Regina T. Martuscello, Nariaki S. Nakamura, Alexander K. Parker, Lan Hoang-Minh
Publikováno v:
Translational Oncology
Translational Oncology, Vol 9, Iss 5, Pp 392-402 (2016)
Translational Oncology, Vol 9, Iss 5, Pp 392-402 (2016)
A better understanding of the molecules implicated in the growth and survival of glioblastoma (GBM) cells and their response to temozolomide (TMZ), the standard-of-care chemotherapeutic agent, is necessary for the development of new therapies that wo
Autor:
Xin Yu, Baoli Yang, Simon D'Alton, Joshua Knight, Ian M. Farnham, Rachel M. Bailey, Yong Jie Zhang, John Howard, Monica Castanedes-Casey, Matthew R. Sarkisian, Brittany Scott, Jada Lewis, Linda Rousseau, Ashley Cannon, Dennis W. Dickson, Wen-Lang Lin, Leonard Petrucelli, Michael Jurasic, Charles A. Wuertzer
Publikováno v:
Acta Neuropathologica
Ubiquitin-immunoreactive neuronal inclusions composed of TAR DNA binding protein of 43 kDa (TDP-43) are a major pathological feature of frontotemporal lobar degeneration (FTLD-TDP). In vivo studies with TDP-43 knockout mice have suggested that TDP-43
Autor:
Raddy L, Ramos, Alyssa R, Toia, Daniel M, Pasternack, Timothy P, Dotzler, Joshua A, Cuoco, Anthony W, Esposito, Megan M, Le, Alexander K, Parker, Jeffrey H, Goodman, Matthew R, Sarkisian
Publikováno v:
Neuroscience. 337
Subcortical band heterotopia (SBH) are malformations of the human cerebral cortex typically associated with epilepsy and cognitive delay/disability. Rodent models of SBH have demonstrated strong face validity as they are accompanied by both cognitive
Autor:
Matthew R. Sarkisian, Defang Luo, Jeremy McIntyre, Lawrence C. Kenyon, Wenyin Shi, Jeffrey L. Harrison
INTRODUCTION: Glioblastomas (GBMs) are characterized by behavioral aggressiveness and a dismal prognosis despite multimodality therapies. While high numbers of microglia/macrophages are found within GBM, little is known of their specific function wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a0356ce0f3899e7090bb5cfba01000
https://europepmc.org/articles/PMC4638864/
https://europepmc.org/articles/PMC4638864/
Autor:
Joseph J. LoTurco, Xiuyin Yin, Yu Wang, Glenn D. Rosen, Lisa A. Gabel, Matthew R. Sarkisian, Sarah M. Guadiana, Albert M. Galaburda
Publikováno v:
Neuroscience. 190:398-408
The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse. Comparisons between Dcdc2
Autor:
Matthew R. Sarkisian
Publikováno v:
Cell Cycle. 9:1873-1877
Autor:
Matthew R. Sarkisian, Jeffrey L. Harrison, Thomas J. Schall, James Campbell, Israel F. Charo, Adithya Gopinath, Defang Luo
Publikováno v:
Neuro-Oncology. 19:vi114-vi114
INTRODUCTION Therapeutic approaches that target the immune system in cancer are gaining traction, with agents that disrupt the PD-L1/PD-1 axis showing success in melanoma and lung cancers. Pre-clinical and early clinical studies also indicate that th
Autor:
Xiuxin Liu, Richard A. Flavell, Matthew R. Sarkisian, Albert E. Ayoub, A. Rachel Gallagher, Anthony F. Ferrandino, Charalampos G. Spilianakis, Ming O. Li, Joshua J. Breunig, Pasko Rakic, Terrence Town
Publikováno v:
Proceedings of the National Academy of Sciences. 105:2853-2858
Cilia are present on nearly all cell types in mammals and perform remarkably diverse functions. However, the mechanisms underlying ciliogenesis are unclear. Here, we cloned a previously uncharacterized highly conserved gene, stumpy , located on mouse
Publikováno v:
Trends in Neurosciences. 31:54-61
Postmitotic cortical neurons that fail to initiate migration can remain near their site of origin and form persistent periventricular nodular heterotopia (PH). In human telencephalon, this malformation is most commonly associated with Filamin-A (FLNa
Publikováno v:
Science. 302:1560-1563
Cells undergoing apoptosis during development are removed by phagocytes, but the underlying mechanisms of this process are not fully understood. Phagocytes lacking the phosphatidylserine receptor (PSR) were defective in removing apoptotic cells. Cons