Zobrazeno 41 - 50
of 65
pro vyhledávání: '"Mats Gåfvels"'
Autor:
Per Stål, Gösta Eggertsen, Rolf Hultcrantz, Petra Holmström, Lennart Eriksson, Vijole Dzikaite, Mats Gåfvels
Publikováno v:
Liver international : official journal of the International Association for the Study of the Liver. 26(8)
Background/Aims: The altered iron metabolism in hepatocellular carcinomas (HCCs), characterized by the iron-deficient phenotype, is suggested to be of importance for tumour growth. However, the underlying molecular mechanisms remain poorly understood
Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice
Autor:
Mats Rudling, Curt Einarsson, Charlotte Murphy, Jin Wang, Mats Gåfvels, Ingemar Björkhem, Gösta Eggertsen
Publikováno v:
Biochemical and biophysical research communications. 342(4)
We studied bile acid and cholesterol metabolism in insulin-dependent diabetes utilizing genetically modified mice unable to synthesize cholic acid (Cyp8b1−/−). Diabetes was induced in Cyp8b1−/− and wild type animals (Cyp8b1+/+) by alloxan, an
Autor:
Mats Gåfvels, Rolf Hultcrantz, Öjar Melefors, Karin Hagen, Per Stål, Vijole Dzikaite, Gösta Eggertsen, Kristina Eckes, Petra Holmström
Publikováno v:
Journal of hepatology. 44(3)
Background/Aims To study the effect of iron and proinflammatory cytokines on the expression of HAMP and other iron regulatory genes in primary rat hepatocytes. Methods Primary hepatocytes from rats fed a control or iron-enriched diet were plated on e
Publikováno v:
Biochimica et biophysica acta. 1735(3)
To study the effects of cholic acid (CA) feeding on hepatic cholesterol metabolism, male sterol 12alpha-hydroxylase (CYP8B1) knockout (-/-) mice and wildtype controls (+/+) were fed either a control diet or the same diet supplemented with CA (0.1% or
Autor:
Ulrika von Döbeln, Sindra Isetun, Anna Karlsson, Kjell Hultenby, Sophie Curbo, Xiaoshan ZhouI, Kristina Kannisto, Mats Gåfvels
Publikováno v:
Mitochondrion. 12:561-562
Autor:
Vijole Dzikaite, Nils Kinnman, Gösta Eggertsen, Rolf Hultcrantz, Kristina Eckes, Per Stål, Bård Smedsrød, Petra Holmström, Mats Gåfvels, Öjar Melefors
Publikováno v:
Journal of hepatology. 39(3)
Background/Aims : Very little is known about the HFE gene in the rat. The aim of the present study was to determine: (1) the structure of the rat HFE gene; and (2) the tissue expression of the HFE mRNA in the rat, with special emphasis on the liver.
Publikováno v:
Karolinska Institutet
Background and aims: The role of the HFE S65C mutation in the development of hepatic iron overload is unknown. The aim of the present study was: (A) to determine the HFE S65C frequency in a Northern European population; and (B) to evaluate whether th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e0c6fc07c0ca89d9a512266ebb109a
https://europepmc.org/articles/PMC1773427/
https://europepmc.org/articles/PMC1773427/
Autor:
Jia Li-Hawkins, Mats Gåfvels, Maria Olin, Erik G. Lund, Ulla Andersson, Gertrud Schuster, Ingemar Björkhem, David W. Russell, Gosta Eggertsen
Publikováno v:
The Journal of clinical investigation. 110(8)
Cholesterol is converted into dozens of primary and secondary bile acids through pathways subject to negative feedback regulation mediated by the nuclear receptor farnesoid X receptor (FXR) and other effectors. Disruption of the sterol 12alpha-hydrox
Publikováno v:
Biochimica et biophysica acta. 1581(1-2)
To characterize endocrine mechanisms of very low density lipoprotein (VLDL) receptor regulation we studied mouse adipocytic 3T3-L1 cells. Lipid filled adipocyte-like cells are formed during a 5-7 day time course in the presence of insulin, dexamethas
Autor:
Yi-Zeng Yang, Claes M. Carneheim, Stefan E.H. Alexson, Mary C. Hunt, Mats Gåfvels, Curt Einarsson, Gösta Eggertsen
Publikováno v:
The Journal of biological chemistry. 275(37)
Fibrates are a group of hypolipidemic agents that efficiently lower serum triglyceride levels by affecting the expression of many genes involved in lipid metabolism. These effects are exerted via the peroxisome proliferator-activated receptor alpha (