Zobrazeno 41 - 50
of 695
pro vyhledávání: '"Mark A Wainberg"'
Autor:
Andrew N, Phillips, Valentina, Cambiano, Fumiyo, Nakagawa, Paul, Revill, Michael R, Jordan, Timothy B, Hallett, Meg, Doherty, Andrea, De Luca, Jens D, Lundgren, Mutsa, Mhangara, Tsitsi, Apollo, John, Mellors, Brooke, Nichols, Urvi, Parikh, Deenan, Pillay, Tobias, Rinke de Wit, Kim, Sigaloff, Diane, Havlir, Daniel R, Kuritzkes, Anton, Pozniak, David, van de Vijver, Marco, Vitoria, Mark A, Wainberg, Elliot, Raizes, Silvia, Bertagnolio
Publikováno v:
The lancet. HIV, vol 5, iss 3
BackgroundThere is concern over increasing prevalence of non-nucleoside reverse-transcriptase inhibitor (NNRTI) resistance in people initiating antiretroviral therapy (ART) in low-income and middle-income countries. We assessed the effectiveness and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7adb446e49322153531331abedbecc08
https://escholarship.org/uc/item/93r5t2hj
https://escholarship.org/uc/item/93r5t2hj
Autor:
Mark A. Wainberg, Bluma G. Brenner, Maureen Oliveira, Hongtao Xu, Nathan Osman, Simrat Bharaj, Thibault Mesplède, Ahmad Alikhani, Said Hassounah, Ruxandra-Ilinca Ibanescu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Animal models are essential to study novel antiretroviral drugs, resistance-associated mutations (RAMs), and treatment strategies. Bictegravir (BIC) is a novel potent integrase strand transfer inhibitor (INSTI) that has shown promising results agains
Autor:
Zabrina L. Brumme, Cassandra N. Naphen, Natalie N. Kinloch, Silven Read, David E. Williams, Brendan Bell, Tristan J. Markle, Philip Mwimanzi, Xiaomei T. Kuang, Mark A. Brockman, Ian Tietjen, Mark A. Wainberg, Emmanuelle Wilhelm, Raymond J. Andersen, Phillip Crews, Karen Tenney, Thibault Mesplède
Publikováno v:
Antiviral research. 152
HIV-1 inhibitors that act by mechanisms distinct from existing antiretrovirals can provide novel insights into viral replication and potentially inform development of new therapeutics. Using a multi-cycle HIV-1 replication assay, we screened 252 pure
Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretrovirals to be approved for the treatment of HIV infection. Canonical resistance to these competitive inhibitors develops through substitutions in the integrase active site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e891e578b62b4218a96d32bdcc5ff37f
https://europepmc.org/articles/PMC5640858/
https://europepmc.org/articles/PMC5640858/
Autor:
Pierre Gantner, Christine Cheneau, Mahsa Mohseni-Zadeh, Marialuisa Partisani, Mark A. Wainberg, Geneviève Beck-Wirth, Jean-Pierre Faller, Martin Martinot, David Rey, Samira Fafi-Kremer, Guinevere Q. Lee, Thibault Mesplède
Publikováno v:
The Journal of antimicrobial chemotherapy. 73(4)
Objectives Better understanding of the dynamics of HIV reservoirs under ART is a critical step to achieve a functional HIV cure. Our objective was to assess the genetic diversity of archived HIV-1 DNA over 48 weeks in blood cells of individuals start
Autor:
Mark A. Wainberg, Thibault Mesplède
Publikováno v:
Viruses
Viruses, Vol 7, Iss 7, Pp 3703-3718 (2015)
Viruses, Vol 7, Iss 7, Pp 3703-3718 (2015)
Drug resistance prevents the successful treatment of HIV-positive individuals by decreasing viral sensitivity to a drug or a class of drugs. In addition to transmitted resistant viruses, treatment-naïve individuals can be confronted with the problem
Autor:
Peter K. Quashie, Nathan Osman, Veronica Zanichelli, Mark A. Wainberg, Thibault Mesplède, Maureen Oliveira
Publikováno v:
Journal of Antimicrobial Chemotherapy. 70:2810-2815
Objectives: Of the currently approved HIV integrase strand transfer inhibitors (INSTIs), dolutegravir has shown greater efficacy than raltegravir at suppressing HIV-1 replication in treatment-experienced individuals. Biochemical experiments have also
Autor:
Thomas Szekeres, Yudong Quan, Hongtao Xu, Mark A. Wainberg, Thibault Mesplède, Peter K. Quashie, Ying-Shan Han, Walter Jaeger
Publikováno v:
Journal of Medical Virology. 87:2054-2060
HIV resistance to current anti-HIV drugs and drug toxicity have created a need for new anti-HIV agents. We have examined and characterized a synthetic resveratrol analog, termed 3,3′,4,4′,5,5′-hexahydroxy-trans-stilbene (M8), for potential anti
Publikováno v:
Tetrahedron. 71:3671-3679
An MS guided fractionation of the alkaloidal constituents of Flueggea virosa has yielded nine new Securinega alkaloid oligomers, fluevirosinines B–J ( 1 – 9 ). The absolute structures of these oligomers have been characterized on the basis of spe
Publikováno v:
Journal of Virology. 89:4681-4684
The new integrase strand transfer inhibitor (INSTI) dolutegravir (DTG) displays limited cross-resistance with older drugs of this class and selects for the R263K substitution in treatment-experienced patients. We performed tissue culture selections w