Zobrazeno 11 - 20
of 31
pro vyhledávání: '"Marc Valentine"'
Autor:
Daniel J. Hiler, Issam Aldiri, Marc Valentine, Abbas Shirinifard, Michael A. Dyer, Suresh Thiagarajan, Xin Zhou, Dianna A. Johnson, Xiang Chen, Jiakun Zhang, Lu Wang, Lyra Griffiths, Andras Sablauer, Marie E. Barabas, Beisi Xu, Sharon Frase
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2601-2614 (2018)
Cell reports
Cell reports
SUMMARY Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifi
Autor:
Marc Valentine, Patrick A. Zweidler-McKay, Sa A. Wang, Kathryn G. Roberts, Nitin Jain, Charles G. Mullighan, Marina Konopleva, Xinyan Lu, Maitrayee Goswami, Jeffrey L. Jorgensen, Sergej Konoplev, Carlos E. Bueso-Ramos, Juan Ouyang
Publikováno v:
American Journal of Clinical Pathology. 147:357-363
Objectives Cytokine receptor-like factor 2 ( CRLF2 ) rearrangement is found in approximately 50% of pediatric Ph-like B-cell acute lymphoblastic leukemia (B-ALL), and around 50% of CRLF2 + cases harbor JAK mutations. We analyzed CRLF2 expression and
Autor:
Xiang Chen, John Easton, Issam Al Diri, Daniel Putnam, Michael A. Dyer, Lyra Griffiths, Beisi Xu, Marc Valentine, Dianna A. Johnson, Shondra Miller, Marybeth S. Lupo, Sharon Frase, Jackie L. Norrie, Jiakun Zhang, Ying Shao, Xin Zhou, Victoria Honnell, Valerie Stewart
Publikováno v:
Neuron
More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhancers are also active in the developing retinae, many having features of cell- and developmental stage-spe
Autor:
Diane Flasch, Jinghui Zhang, Yanling Liu, Michael Rusch, Suzanne J. Baker, Robin Paul, Jaimin Patel, Chunliang Li, Ying Shao, Edgar Sioson, Xiaotu Ma, Yu Liu, Liqing Tian, John Easton, Marc Valentine, Samuel W. Brady, Scott Newman, Jian Wang, Xin Zhou, Michael N. Edmonson
Publikováno v:
Cancer Cell
GenomePaint (https://genomepaint.stjude.cloud/) is an interactive visualization platform for whole-genome, whole-exome, transcriptome, and epigenomic data of tumor samples. Its design captures the inter-relatedness between DNA variations and RNA expr
Autor:
Shunsuke Kimura, Charles G. Mullighan, Jeffery M. Klco, Xiao-Long Chen, Xiaotu Ma, Anna Stengel, Sonja Seliger, Zhaohui Gu, Wolfgang Kern, Chunxu Qu, Ilaria Iacobucci, Torsten Haferlach, Lindsey E. Montefiori, Jing Ma, Marc Valentine, Kirsten Dickerson, Beisi Xu, Tamara Westover, Gang Wu, Claudia Haferlach
Publikováno v:
Blood. 136:LBA-3
Lindsey Montefiori, Sonja Seliger, and Zhaohui Gu contributed equally. Acute leukemias of ambiguous lineage (ALAL), including those that express combinations of myeloid, T-lineage and stem cell markers such as T/myeloid mixed phenotype acute leukemia
Autor:
Philip C. Wong, Fen-Biao Gao, Nam Chul Kim, Rodrigo Lopez-Gonzalez, Brian D. Freibaum, Bruce L. Miller, Leonard Petrucelli, Nisha M. Badders, Hong Joo Kim, J. Paul Taylor, Sandra Almeida, Marc Valentine, Kyung-Ha Lee, Yubing Lu
Publikováno v:
Nature, vol 525, iss 7567
The GGGGCC (G4C2) repeat expansion in a noncoding region of C9orf72 is the most common cause of sporadic and familial forms of amyotrophic lateral sclerosis and frontotemporal dementia. The basis for pathogenesis is unknown. To elucidate the conseque
Autor:
Abbas Shirinifard, Issam Al Diri, Dianna Johnson, Michael A. Dyer, Daniel Putnam, Marybeth S. Lupo, Jiakun Zhang, Sharon Frase, Shondra Miller, Beisi Xu, John Easton, Jackie L. Norrie, Valerie Stewart, Xiang Chen, Ying Shao, Marc Valentine, Lyra Griffiths, Victoria Honnell
The nuclei of rod photoreceptors in mice and other nocturnal species have an unusual inverted chromatin structure: the heterochromatin is centrally located to help focus light and improve photosensitivity. To better understand this unique nuclear org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcc49bd83f0e20fbbf7b270746cd811
https://doi.org/10.1101/369702
https://doi.org/10.1101/369702
Autor:
Seungjae Lee, Elizabeth Stewart, James R. Downing, Armita Bahrami, Heather L. Mulder, Marc Valentine, Jianrong Wu, Rani E. George, Donald Yergeau, Michael D. Hogarty, Maged Zeineldin, Elaine R. Mardis, Xin Zhou, Sara M. Federico, Beisi Xu, Anang A. Shelat, Richard K. Wilson, Yanling Liu, Jinghui Zhang, Jongrye Jeon, Arlene Naranjo, Shondra M. Pruett-Miller, John Easton, Michael R. Clay, Collin Van Ryn, Lyra Griffiths, Xiang Chen, Yiping Fan, Marcin Kamiński, Alberto S. Pappo, Michael A. Dyer
SUMMARYAggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9c9691bc389d4e691e3cbd0c5b70af
https://doi.org/10.1101/379636
https://doi.org/10.1101/379636
Autor:
Jinghui Zhang, Richard C. Harvey, Julie M. Gastier-Foster, Cheryl L. Willman, Nyla A. Heerema, Leonard A. Mattano, Mignon L. Loh, Kathryn G. Roberts, William L. Carroll, Shalini C. Reshmi, Zhaohui Gu, Marc Valentine, Debbie Payne-Turner, Andrew J. Carroll, Heather Jenkins, Michael J. Borowitz, Brent L. Wood, Elizabeth A. Raetz, Kinnari Patel, I-Ming Chen, Meenakshi Devidas, Yaqi Zhao, Charles G. Mullighan, Eileen Stonerock, Yunfeng Dai, Stephen P. Hunger, Kelly W. Maloney
Publikováno v:
Blood. 132(8)
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL; BCR-ABL1-like ALL) in children with National Cancer Institute (NCI) intermediate- or high-risk (HR) ALL is associated with poor outcome. Ph-like ALL is characterized by genetic a
Autor:
Vaibhav Sahai, Jerold E. Rehg, Lesa Begley, David Escobar, Marc Valentine, Peter J. McKinnon, Jianming Ye, Ming Yi Chiang, Beatriz Sosa-Pineda, Leena Paul, Yiannis Drosos, Virginia Valentine, Kathryn Roys
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Germline mutations in ATM (encoding the DNA-damage signaling kinase, ataxia-telangiectasia-mutated) increase Familial Pancreatic Cancer (FPC) susceptibility, and ATM somatic mutations have been identified in resected human pancreatic tumors. Here we