Zobrazeno 31 - 40
of 261
pro vyhledávání: '"Mahdad Noursadeghi"'
Autor:
Jimstan Periselneris, Giuseppe Ercoli, Tracey Pollard, Suneeta Chimalapati, Emilie Camberlein, Gabriella Szylar, Catherine Hyams, Gillian Tomlinson, Fernanda C. Petersen, R. Andres Floto, Mahdad Noursadeghi, Jeremy S. Brown
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Both intracellular immune sensing and extracellular innate immune sensing have been implicated in initiating macrophage proinflammatory cytokine responses to Streptococcus pneumoniae. The S. pneumoniae capsule, a major virulence determinant,
Externí odkaz:
https://doaj.org/article/d089ef97c70043238d89741d49e77722
Autor:
André N. A. Gonçalves, Melissa Lever, Pedro S. T. Russo, Bruno Gomes-Correia, Alysson H. Urbanski, Gabriele Pollara, Mahdad Noursadeghi, Vinicius Maracaja-Coutinho, Helder I. Nakaya
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Transcriptome analyses have increased our understanding of the molecular mechanisms underlying human diseases. Most approaches aim to identify significant genes by comparing their expression values between healthy subjects and a group of patients wit
Externí odkaz:
https://doaj.org/article/a1aeaa364c774bee95cc4aebf392b5d8
Autor:
Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Roslyn A. Hendriks, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/d740ed64c3ac49a68c827986110142dc
Autor:
Laura J. Shallcross, Alexander Mentzer, Saadia Rahman, Graham S. Cooke, Shiranee Sriskandan, Mahdad Noursadeghi
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Introduction: Infectious diseases have a major impact on morbidity and mortality in hospital. Microbial diagnosis remains elusive for most cases of suspected infection which impacts on the use of antibiotics. Rapid advances in genomic technologies co
Externí odkaz:
https://doaj.org/article/258c43b6023049e0be486ab13c5126d3
Autor:
Theres Oakes, James M. Heather, Katharine Best, Rachel Byng-Maddick, Connor Husovsky, Mazlina Ismail, Kroopa Joshi, Gavin Maxwell, Mahdad Noursadeghi, Natalie Riddell, Tabea Ruehl, Carolin T. Turner, Imran Uddin, Benny Chain
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The T cell receptor (TCR) repertoire can provide a personalized biomarker for infectious and non-infectious diseases. We describe a protocol for amplifying, sequencing, and analyzing TCRs which is robust, sensitive, and versatile. The key experimenta
Externí odkaz:
https://doaj.org/article/86028040762a42f1a79c1257127e1712
Publikováno v:
International Journal of Infectious Diseases, Vol 32, Iss C, Pp 39-45 (2015)
The coalescence of the HIV-1 and tuberculosis (TB) epidemics in Sub-Saharan Africa has had a significant and negative impact on global health. The availability of effective antimicrobial treatment for both HIV-1 (in the form of highly active antiretr
Externí odkaz:
https://doaj.org/article/cd7085977167448c80b4e2f7be2d630d
Autor:
Rachel Byng-Maddick, Carolin T. Turner, Gabriele Pollara, Matthew Ellis, Naomi J. Guppy, Lucy C. K. Bell, Michael R. Ehrenstein, Mahdad Noursadeghi
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The impact of anti-tumor necrosis factor (TNF) therapies on inducible TNF-dependent activity in humans has never been evaluated in vivo. We aimed to test the hypothesis that patients responding to anti-TNF treatments exhibit attenuated TNF-dependent
Externí odkaz:
https://doaj.org/article/c22d2d58da354ddfbab38abe151315d1
Autor:
Gabriele Pollara, Matthew J Murray, James M Heather, Rachel Byng-Maddick, Naomi Guppy, Matthew Ellis, Carolin T Turner, Benjamin M Chain, Mahdad Noursadeghi
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169271 (2017)
Numerous gene signatures, or modules have been described to evaluate the immune cell composition in transcriptomes of multicellular tissue samples. However, significant diversity in module gene content for specific cell types is associated with heter
Externí odkaz:
https://doaj.org/article/b6d96bebc5964668a31d80fb86bad66f
Autor:
Lucy C K Bell, Gabriele Pollara, Mellissa Pascoe, Gillian S Tomlinson, Rannakoe J Lehloenya, Jennifer Roe, Richard Meldau, Robert F Miller, Alan Ramsay, Benjamin M Chain, Keertan Dheda, Mahdad Noursadeghi
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005469 (2016)
Increased risk of tuberculosis (TB) associated with HIV-1 infection is primarily attributed to deficient T helper (Th)1 immune responses, but most people with active TB have robust Th1 responses, indicating that these are not sufficient to protect ag
Externí odkaz:
https://doaj.org/article/2756ecfddd6448d2884a1415dc005b6c
Autor:
Joseph N Jarvis, Graeme Meintjes, Tihana Bicanic, Viviana Buffa, Louise Hogan, Stephanie Mo, Gillian Tomlinson, Pascale Kropf, Mahdad Noursadeghi, Thomas S Harrison
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004754 (2015)
Understanding the host immune response during cryptococcal meningitis (CM) is of critical importance for the development of immunomodulatory therapies. We profiled the cerebrospinal fluid (CSF) immune-response in ninety patients with HIV-associated C
Externí odkaz:
https://doaj.org/article/5dc3a07824c74e7ab721e90b6f690bec