Zobrazeno 11 - 20
of 1 835
pro vyhledávání: '"Macrae F"'
Autor:
Lin Zhu, Julia An, Sivaprakasam Chinnarasu, Thao Luu, Yasminye D. Pettway, Kelly Fahey, Bridget Litts, Hye-Young H. Kim, Charles R. Flynn, MacRae F. Linton, John M. Stafford
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Mounting evidence has shown that CETP has important physiological roles in adapting to chronic nutrient excess, specifically, to protect against diet-induced insulin resistance. However, the underlying mechanisms for the protective roles of CETP in m
Externí odkaz:
https://doaj.org/article/d13b563333c6492787d6d4eb6f12ac44
Autor:
Huan Tao, Jiansheng Huang, Patricia G. Yancey, Valery Yermalitsky, John L. Blakemore, Youmin Zhang, Lei Ding, Irene Zagol-Ikapitte, Fei Ye, Venkataraman Amarnath, Olivier Boutaud, John A. Oates, L. Jackson Roberts, Sean S. Davies, MacRae F. Linton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HD
Externí odkaz:
https://doaj.org/article/1e1c9269b742425ab2397a10869c4faa
Autor:
Loren E. Smith, Derek K. Smith, Patricia G. Yancey, Valentina Kon, Alan T. Remaley, Frederic T. Billings, IV, MacRae F. Linton
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100024- (2021)
Oxidative stress promotes acute kidney injury (AKI). Higher HDL cholesterol concentrations are associated with less AKI. To test the hypothesis that HDL antioxidant activity is associated with AKI after cardiac surgery, we quantified HDL particle (HD
Externí odkaz:
https://doaj.org/article/342f0fbe2872494483a93970447910b2
Autor:
Lin Zhu, Jeanne Shi, Thao N. Luu, Joshua C. Neuman, Elijah Trefts, Sophia Yu, Brian T. Palmisano, David H. Wasserman, MacRae F. Linton, John M. Stafford
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 106-116 (2018)
Objective: Hepatocyte deletion of estrogen receptor alpha (LKO-ERα) worsens fatty liver, dyslipidemia, and insulin resistance in high-fat diet fed female mice. However, whether or not hepatocyte ERα regulates reverse cholesterol transport (RCT) in
Externí odkaz:
https://doaj.org/article/280e1ee22eac4ce5bbf61622a910d72b
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8201 (2021)
Decades of epidemiological studies have established the strong inverse relationship between high-density lipoprotein (HDL)-cholesterol concentration and cardiovascular disease. Recent evidence suggests that HDL particle functions, including anti-infl
Externí odkaz:
https://doaj.org/article/bc076d5830a644b985d2e3c9bc315e72
Autor:
Xuchen Hu, Mark W. Sleeman, Kazuya Miyashita, MacRae F. Linton, Christopher M. Allan, Cuiwen He, Mikael Larsson, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Alaleh Mapar, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 208-215 (2017)
GPIHBP1, an endothelial cell protein, binds LPL in the interstitial spaces and shuttles it to its site of action inside blood vessels. For years, studies of human GPIHBP1 have been hampered by an absence of useful antibodies. We reasoned that monoclo
Externí odkaz:
https://doaj.org/article/2cd466d9dd7b46b5858c18eb7905f80f
Autor:
Alanna M. Chamberlain, Yan Gong, Kathryn McAuliffe Shaw, Jiang Bian, Wen‐Liang Song, MacRae F. Linton, Vivian Fonseca, Eboni Price‐Haywood, Emily Guhl, Jordan B. King, Rashmee U. Shah, Jon Puro, Elizabeth Shenkman, Pamala A. Pawloski, Karen L. Margolis, Adrian F. Hernandez, Rhonda M. Cooper‐DeHoff
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 9 (2019)
Background PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors effectively lower LDL (low‐density lipoprotein) cholesterol and have been shown to reduce cardiovascular outcomes in high‐risk patients. We used real‐world electronic h
Externí odkaz:
https://doaj.org/article/2b0cc7e3c36a4d0d8344b1742715d921
Autor:
Ryan M. Allen, Shilin Zhao, Marisol A. Ramirez Solano, Wanying Zhu, Danielle L. Michell, Yuhuan Wang, Yu Shyr, Praveen Sethupathy, MacRae F. Linton, Gregory A. Graf, Quanhu Sheng, Kasey C. Vickers
Publikováno v:
Journal of Extracellular Vesicles, Vol 7, Iss 1 (2018)
To comprehensively study extracellular small RNAs (sRNA) by sequencing (sRNA-seq), we developed a novel pipeline to overcome current limitations in analysis entitled, “Tools for Integrative Genome analysis of Extracellular sRNAs (TIGER)”. To demo
Externí odkaz:
https://doaj.org/article/7a35d40986b3418c892ee4a7ab71ad1e
Autor:
Jiansheng Huang, Patricia G. Yancey, Huan Tao, Mark S. Borja, Loren E. Smith, Valentina Kon, Sean S. Davies, MacRae F. Linton
Publikováno v:
Nutrients, Vol 12, Iss 7, p 1937 (2020)
Atheroprotective functions of high-density lipoproteins (HDL) are related to the activity of HDL-associated enzymes such as paraoxonase 1 (PON1). We examined the impact of inhibition of myeloperoxidase (MPO)-mediated HDL oxidation by PON1 on HDL malo
Externí odkaz:
https://doaj.org/article/2f59c9f5852d482bb17bb5851059f969
Autor:
QiPing Feng, Wei-Qi Wei, Cecilia P Chung, Rebecca T Levinson, Alexandra C Sundermann, Jonathan D Mosley, Lisa Bastarache, Jane F Ferguson, Nancy J Cox, Dan M Roden, Joshua C Denny, MacRae F Linton, Digna R Velez Edwards, C Michael Stein
Publikováno v:
PLoS Medicine, Vol 15, Iss 8, p e1002642 (2018)
BACKGROUND:Observations from statin clinical trials and from Mendelian randomization studies suggest that low low-density lipoprotein cholesterol (LDL-C) concentrations may be associated with increased risk of type 2 diabetes mellitus (T2DM). Despite
Externí odkaz:
https://doaj.org/article/bbb947f0461d4dfcbc0c34e59c03d106