Zobrazeno 41 - 50
of 463
pro vyhledávání: '"MacConaill, Laura"'
Autor:
MacConaill, Laura, Burns, Robert, Anwesha Nag, Coleman, Haley, Slevin, Michael, Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew, Ducar, Matthew, Meyerson, Matthew, Thorner, Aaron
Mutation-specific thresholds provide additional improvements to calling accuracy. (a) Number of false positives from 8-oxoguanine errors are found at low frequencies. (b) Increased minimum variant allele frequency thresholds for 8-oxoguanine mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba583892471e54fa4b8957c6ae136d0b
Autor:
MacConaill, Laura, Burns, Robert, Anwesha Nag, Coleman, Haley, Slevin, Michael, Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew, Ducar, Matthew, Meyerson, Matthew, Thorner, Aaron
Multiplex captures have comparable uniformity to individual captures. Uniform coverage enables accurate variant calling with minimal sequencing cost. (PDF 115 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5fe0f8d9c424aebb65b3eebd73204e6
Autor:
MacConaill, Laura, Burns, Robert, Anwesha Nag, Coleman, Haley, Slevin, Michael, Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew, Ducar, Matthew, Meyerson, Matthew, Thorner, Aaron
Level of cross-talk using combinatorial indices on Illumina HiSeq 2500. The 96-well plate layout represents the adapter plate. A total of 19 patient-derived xenograft (PDX) libraries were prepared using IDT-synthesized TS-96 adapters (green), librari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bcf759401358933aca4c4b0ca97dd06
Autor:
MacConaill, Laura, Burns, Robert, Anwesha Nag, Coleman, Haley, Slevin, Michael, Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew, Ducar, Matthew, Meyerson, Matthew, Thorner, Aaron
Adapter plate layout for multiplexing experiments. (PDF 829 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47b41057d2bf6e73d23df8a129e1562e
Autor:
MacConaill, Laura, Burns, Robert, Anwesha Nag, Coleman, Haley, Slevin, Michael, Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew, Ducar, Matthew, Meyerson, Matthew, Thorner, Aaron
Comparing the level of cross-talk using combinatorial adapters between the Illumina HiSeq 2500 and Illumina HiSeq 3000/4000 platforms. The 96-well plate layout represents the adapter plate. Two samples underwent library construction using IDT-synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::922ecde51913840a4d8d0890af58254e
Autor:
MacConaill, Laura, Burns, Robert, Anwesha Nag, Coleman, Haley, Slevin, Michael, Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew, Ducar, Matthew, Meyerson, Matthew, Thorner, Aaron
Schematic of the experiment used to measure adapter contamination and multiplexed capture index hopping. Replicate libraries were prepared using 16 unique dual-matched UMI adapters and enriched with the IDT xGen AML Cancer Panel in pools of 1, 4, 8,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c55e87f2c0861407d671a2103286bb6
Autor:
MacConaill, Laura, Burns, Robert, Anwesha Nag, Coleman, Haley, Slevin, Michael, Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew, Ducar, Matthew, Meyerson, Matthew, Thorner, Aaron
Standard sample indexing and library construction. (a) Plate layout of standard combinatorial indexed adapters. A total of 20 different adapters are used to create 96 unique indices, such that the i5 and i7 sequences are different in each plate well.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a3b869d0bb74ad577639db114ab89d
Autor:
MacConaill, Laura, Burns, Robert, Anwesha Nag, Coleman, Haley, Slevin, Michael, Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew, Ducar, Matthew, Meyerson, Matthew, Thorner, Aaron
Level of cross-talk using unique, dual-matched indexed adapters on Illumina HiSeq 2500. The 96-well plate layout represents the adapter plate. A total of 35 adapters were synthesized. Thirty-four samples consisting of PDX (n = 4), tissue samples (n =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2757815a890ee6889e30950f0647fc02
Autor:
Bardeesy Nabeel, Ferrone Cristina, Lauwers Gregory Y, MacConaill Laura E, Kehoe Sarah M, Zimmerman Stephanie M, Nduaguba Afamefuna, Deshpande Vikram, Zhu Andrew X, Hezel Aram F
Publikováno v:
BMC Cancer, Vol 11, Iss 1, p 60 (2011)
Abstract Background The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined. Methods To better characterize
Externí odkaz:
https://doaj.org/article/098bf56d232a42d3ae43c8abebc83571
Autor:
Kehoe Sarah M, Barretina Jordi G, MacConaill Laura E, Sazegar Hooman, Mok Stephen, Hsueh Teli, Guo Deliang, Wang Qi, Nazarian Ramin, Søndergaard Jonas N, Attar Narsis, von Euw Erika, Zuckerman Jonathan E, Chmielowski Bartosz, Comin-Anduix Begoña, Koya Richard C, Mischel Paul S, Lo Roger S, Ribas Antoni
Publikováno v:
Journal of Translational Medicine, Vol 8, Iss 1, p 39 (2010)
Abstract Blocking oncogenic signaling induced by the BRAFV600E mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in melanoma cell lines. PLX4032 d
Externí odkaz:
https://doaj.org/article/6fff43b663ca40a9a338bc0bb035ebf6