Zobrazeno 11 - 20
of 98
pro vyhledávání: '"M. Kyle Hadden"'
Autor:
Marcello Stanzione, Jun Zhong, Edmond Wong, Thomas J. LaSalle, Jillian F. Wise, Antoine Simoneau, David T. Myers, Sarah Phat, Moshe Sade-Feldman, Michael S. Lawrence, M. Kyle Hadden, Lee Zou, Anna F. Farago, Nicholas J. Dyson, Benjamin J. Drapkin
Publikováno v:
Science Advances. 8
In small cell lung cancer (SCLC), acquired resistance to DNA-damaging therapy is challenging to study because rebiopsy is rarely performed. We used patient-derived xenograft models, established before therapy and after progression, to dissect acquire
Publikováno v:
Expert Opin Investig Drugs
INTRODUCTION: Translesion synthesis (TLS) is a DNA damage tolerance mechanism that replaces the replicative DNA polymerase with a specialized, low-fidelity TLS DNA polymerase that can copy past DNA lesions during active replication. Recent studies ha
Autor:
Angela M. Zaino, M. Kyle Hadden
Publikováno v:
Journal of Chemical Education. 97:1543-1548
The Pre-College Summer Program at the University of Connecticut is designed to introduce upper-level high school students (rising juniors and seniors) to college life by allowing them to live on ca...
Autor:
Jiachen Wen, M. Kyle Hadden
Publikováno v:
European journal of medicinal chemistry. 228
Vitamin D3 (VD3) is a seco-steroid that inhibits the Hedgehog (Hh) signaling pathway. Initial studies suggested its anti-Hh activity results from direct inhibition of Smoothened, a seven-transmembrane cell surface receptor that is a key regulator of
Autor:
Pei Zhou, David Argyle, Won Young Lim, Erica N Lamkin, Nimrat Chatterjee, Mark Gray, M. Kyle Hadden, Jiyong Hong, Kira J Fisher, Dmitry M. Korzhnev, Andrew Crompton, Jamie Deutsch, Kanayo E Ikeh
Publikováno v:
Ikeh, K E, Lamkin, E N, Crompton, A, Deutsch, J, Fisher, K J, Gray, M, Argyle, D J, Lim, W Y, Korzhnev, D M, Hadden, M K, Hong, J, Zhou, P & Chatterjee, N 2021, ' REV1 Inhibition Enhances Radioresistance and Autophagy ', Cancers, vol. 13, no. 21 . https://doi.org/10.3390/cancers13215290
Cancers
Cancers, Vol 13, Iss 5290, p 5290 (2021)
Cancers; Volume 13; Issue 21; Pages: 5290
Cancers
Cancers, Vol 13, Iss 5290, p 5290 (2021)
Cancers; Volume 13; Issue 21; Pages: 5290
Simple Summary Cancer resistance to therapy continues to be the biggest challenge in treating patients. Targeting the mutagenic translesion synthesis (TLS) polymerase REV1 was previously shown to sensitize cancer cells to chemotherapy. In this study,
Autor:
Radha Charan Dash, Kaitlyn R. McCarthy, M. Kyle Hadden, Cynthia A. Harris, Dmitry M. Korzhnev, Alessandro A. Rizzo, Nimrat Chatterjee, Zuleyha Ozen, Graham C. Walker
Publikováno v:
ChemMedChem
PMC
PMC
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Translesion synthesis (TLS) has emerged as a mechanism through which several forms of cancer develop acquired resistance to first-line genotoxic chemotherapies by allowing replication to continue in
Publikováno v:
European Journal of Medicinal Chemistry. 162:495-506
The Hedgehog (Hh) pathway is a developmental pathway with therapeutic potential as a target for a variety of cancers. In recent years, several vitamin D-based compounds have been identified as potent inhibitors of Hh signaling. These analogues contai
Autor:
Radha Charan Dash, Dmitry M. Korzhnev, Irina Bezsonova, Angela M. Zaino, M. Kyle Hadden, Yunfeng Li, Alessandro A. Rizzo, Bing Hao, Kerry Silva McPherson
Publikováno v:
ChemMedChem
Rev1 is a protein scaffold of the translesion synthesis (TLS) pathway, which employs low-fidelity DNA polymerases for replication of damaged DNA. The TLS pathway helps cancers tolerate DNA damage induced by genotoxic chemotherapy, and increases mutag
Autor:
Christopher O Dusek, M. Kyle Hadden
Publikováno v:
Expert opinion on drug discovery. 16(3)
GLI1 is a transcription factor that has been identified as a downstream effector for multiple tumorigenic signaling pathways. These include the Hedgehog, RAS-RAF-MEK-ERK, and PI3K-AKT-mTOR pathways, which have all been separately validated as individ
Autor:
M. Kyle Hadden, Anna Hakey, Young Tang, Radha Charan Dash, Chang Huang, Antonio E. Garmendia, Denzil Bernard, Alexander Chu, Alec Knupp, Jiaqi Zhu
Publikováno v:
Virology Journal
Virology Journal, Vol 17, Iss 1, Pp 1-11 (2020)
Virology Journal, Vol 17, Iss 1, Pp 1-11 (2020)
Background Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting the pork industry globally. PRRS is caused by PRRS virus (PRRSV). Currently there are no effective treatments against this