Zobrazeno 21 - 30
of 103
pro vyhledávání: '"Lukas Reiter"'
Autor:
Aleš, Holfeld, Jan-Philipp, Quast, Roland, Bruderer, Lukas, Reiter, Natalie, de Souza, Paola, Picotti
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2554
Metabolite-protein interactions regulate diverse cellular processes, prompting the development of methods to investigate the metabolite-protein interactome at a global scale. One such method is our previously developed structural proteomics approach,
Autor:
Evelyn Lattmann, Luca Räss, Marco Tognetti, Julia Martinez Gomez, Valérie Lapaire, Roland Bruderer, Lukas Reiter, Yuehan Feng, Lars M. Steinmetz, Mitchell P. Levesque
Publikováno v:
Cancer Research. 83:4352-4352
Extracellular vesicles (EV) play an important role in melanoma progression but their potential as clinical biomarkers has yet to be realized. EVs can be found in most liquid biopsies (e.g., blood, urine, CSF) and exosomes are the most prominent subca
Autor:
Ilja E. Shapiro, Luca Räss, Christopher R. Below, Marco Tognetti, Tikira Temu, Oliver M. Bernhardt, Roland Bruderer, Jonathan Woodsmith, Lukas Reiter
Publikováno v:
Cancer Research. 83:2991-2991
Colorectal cancer (CRC) is currently the second most common cause of cancer related mortality in the world. One of the hallmarks of CRC is its complex mutational landscape that contributes to the derivation of neoantigens which aid the immunosurveill
Autor:
Sebastian Müller, Véronique Laforte, Simonas Savickas, Maik Müller, Yuehan Feng, Lukas Reiter
Publikováno v:
Cancer Research. 83:5059-5059
Proteins represent a key class of analytes in pharmacodynamic (PD) analysis, an essential component in preclinical and clinical studies which inform about a biological system’s response to drug treatment. Pharmacodynamic signatures typically compri
Publikováno v:
Molecular & Cellular Proteomics : MCP
DIA profiles of complex biological matrices such as tissues can contain quantitative interferences, and the interferences at the MS1 and the MS2 signals are often independent. We developed a statistical procedure incorporating both MS1 and MS2 quanti
Autor:
Eric Bonneil, Qing Ma, Lukas Reiter, Isabelle Sirois, Joel Lanoix, Etienne Caron, Roland Bruderer, Pierre Thibault, Laura Wessling, David Hamelin, Pouya Faridi, Jerome Despault, Frederic Saab, Eustache Paramithiotis, Chen Li, Mathieu Courcelles, Anthony W. Purcell, Anne Jang, Peter Kubiniok, Kevin A. Kovalchik, Marco Tognetti
Publikováno v:
Molecular & Cellular Proteomics : MCP
MS-based immunopeptidomics is maturing into an automatized and high-throughput technology, producing small- to large-scale datasets of clinically relevant major histocompatibility complex (MHC) class I-associated and class II-associated peptides. Con
Autor:
Liliana Malinovska, Valentina Cappelletti, Devon Kohler, Ilaria Piazza, Tsung-Heng Tsai, Monika Pepelnjak, Patrick Stalder, Christian Dörig, Fabian Sesterhenn, Franziska Elsässer, Lucie Kralickova, Nigel Beaton, Lukas Reiter, Natalie de Souza, Olga Vitek, Paola Picotti
Publikováno v:
Nature Protocols, 18 (3)
Proteins regulate biological processes by changing their structure or abundance to accomplish a specific function. In response to a perturbation, protein structure may be altered by various molecular events, such as post-translational modifications,
Autor:
Marie-Therese Mackmull, Luise Nagel, Fabian Sesterhenn, Jan Muntel, Jan Grossbach, Patrick Stalder, Roland Bruderer, Lukas Reiter, Wilma D. J. van de Berg, Natalie de Souza, Andreas Beyer, Paola Picotti
Publikováno v:
Nature structural & molecular biology, 29(10), 978-+. Nature Publishing Group
Nature Structural & Molecular Biology
Mackmull, M-T, Nagel, L, Sesterhenn, F, Muntel, J, Grossbach, J, Stalder, P, Bruderer, R, Reiter, L, van de Berg, W D J, de Souza, N, Beyer, A & Picotti, P 2022, ' Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker ', Nature structural & molecular biology, vol. 29, no. 10, pp. 978-+ . https://doi.org/10.1038/s41594-022-00837-0
Nature Structural & Molecular Biology, 29 (10)
Nature Structural & Molecular Biology
Mackmull, M-T, Nagel, L, Sesterhenn, F, Muntel, J, Grossbach, J, Stalder, P, Bruderer, R, Reiter, L, van de Berg, W D J, de Souza, N, Beyer, A & Picotti, P 2022, ' Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker ', Nature structural & molecular biology, vol. 29, no. 10, pp. 978-+ . https://doi.org/10.1038/s41594-022-00837-0
Nature Structural & Molecular Biology, 29 (10)
Parkinson's disease (PD) is a prevalent neurodegenerative disease for which robust biomarkers are needed. Because protein structure reflects function, we tested whether global, in situ analysis of protein structural changes provides insight into PD p
Autor:
Ying Jin, Xiaoyu An, Binchen Mao, Ruilin Sun, Rajendra Kumari, Xiaobo Chen, Yongli Shan, Mingfa Zang, Ling Xu, Jan Muntel, Kristina Beeler, Roland Bruderer, Lukas Reiter, Sheng Guo, Demin Zhou, Qi-Xiang Li, Xuesong Ouyang
Publikováno v:
Scientific reports. 12(1)
Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal tumor immunity via different mechanisms of actions (MOAs), particularly various tumor-infiltrate leukocytes (TILs). We modeled loss of function (LOF) in four common
Autor:
Adam Hendricks, Nigel Beaton, Alexey Chernobrovkin, Eric Miele, Ghaith Hamza, Piero Ricchiuto, Ronald Tomlinson, Tomas Friman, Cassandra Borenstein, Bernard Barlaam, Sudhir Hande, Chris De Savi, Rick Davies, Martin Main, Joakim Hellner, Kristina Beeler, Yuehan Feng, Roland Bruderer, Lukas Reiter, Daniel Martinez Molina, Maria Paola Castaldi
Publikováno v:
Cancer Research. 82:2924-2924
In an effort to map the selectivity and understand the mode of action of a CDK9 inhibitor (compound 1), we employed several orthogonal proteomics methods. Our results show a clear selectivity against the CDK family of kinases, with the highest specif