Zobrazeno 31 - 40
of 65
pro vyhledávání: '"Larissa V. Ponomareva"'
Autor:
Sherif I. Elshahawi, Shanteri Singh, Hongnan Cao, H. Peter Spielmann, George N. Phillips, Jon S. Thorson, Mark L. Farman, Khaled A. Shaaban, Larissa V. Ponomareva, Thangaiah Subramanian
Publikováno v:
Nature chemical biology
This study highlights the biochemical and structural characterization of the L-tryptophan C-6 C-prenyltransferase PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including
Autor:
Jon S. Thorson, Renata Rodrigues, Khaled A. Shaaban, Chirlei Glienke, Jürgen Rohr, Larissa V. Ponomareva, Sandriele Aparecida Noriler, Daiani Cristina Savi
Publikováno v:
Fitoterapia
Endophytic have been considered a rich source for bioactive secondary metabolites with novel chemical structures. A high diverse group of endophytes, isolated from different medicinal plants, belongs to the genus Diaporthe. In a previously study perf
Autor:
Chirlei Glienke, Nathalia Vargas, Jon S. Thorson, Larissa V. Ponomareva, Yvelise M. Possiede, Khaled A. Shaaban, Daiani Cristina Savi, Jürgen Rohr
Publikováno v:
Current Microbiology. 70:345-354
Endophytic actinomycetes encompass bacterial groups that are well known for the production of a diverse range of secondary metabolites. Vochysia divergens is a medicinal plant, common in the "Pantanal" region (Brazil) and was focus of many investigat
Autor:
Francielly Maria Wilke Ramos Gos, Chirlei Glienke, Jon S. Thorson, Jürgen Rohr, Daiani Cristina Savi, Larissa V. Ponomareva, Khaled A. Shaaban
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Microorganisms associated with plants are highly diverse and can produce a large number of secondary metabolites, with antimicrobial, anti-parasitic and cytotoxic activities. We are particularly interested in exploring endophytes from medicinal plant
Autor:
Xiachang Wang, James C. Hower, Jürgen Rohr, Steven G. Van Lanen, Khaled A. Shaaban, Gregory C. Copley, Sherif I. Elshahawi, Xiabin Chen, Chang-Guo Zhan, Yinan Zhang, Larissa V. Ponomareva, Sean Parkin, Wenlong Cai, Jon S. Thorson
Publikováno v:
Journal of natural products. 80(4)
The structures of 12 new “enantiomeric”-like abyssomicin metabolites (abyssomicins M–X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abysso
Autor:
Jon S. Thorson, Jianjun Zhang, Nitin S. Nandurkar, Qing-Bai She, Qing Ye, Larissa V. Ponomareva
Publikováno v:
Journal of Medicinal Chemistry
A facile route to perillyl alcohol (POH) differential glycosylation and the corresponding synthesis of a set of 34 POH glycosides is reported. Subsequent in vitro studies revealed a sugar dependent antiproliferative activity and the inhibition of S6
Autor:
Madan K. Kharel, Jon S. Thorson, Gregory C. Copley, Manjula Sunkara, Khaled A. Shaaban, Sherif I. Elshahawi, Xiachang Wang, James C. Hower, Andrew J. Morris, Larissa V. Ponomareva
Publikováno v:
The Journal of antibiotics
Two new cyclopeptides, mullinamides A [cyclo-(-l-Gly-l-Glu-l-Val-l-Ile-l-Pro-)] and B [cyclo-(-l-Glu-l-Met-l-Pro-)] were isolated from the crude extract of terrestrial Streptomyces sp. RM-27-46 along with the three known cyclopeptides surugamide A [c
Autor:
Wenlong, Cai, Xiachang, Wang, Sherif I, Elshahawi, Larissa V, Ponomareva, Xiaodong, Liu, Matthew R, McErlean, Zheng, Cui, Ashley L, Arlinghaus, Jon S, Thorson, Steven G, Van Lanen
Publikováno v:
Journal of natural products. 79(10)
Four new Y-type actinomycin analogues named Y6–Y9 (1–4) were isolated and characterized from the scale up fermentation of the Streptomyces sp. strain Gö-GS12, as well as actinomycin Zp (5) that was, for the first time, isolated as a natural prod
Autor:
Xiachang Wang, Manjula Sunkara, James C. Hower, Khaled A. Shaaban, Jon S. Thorson, Andrew J. Morris, Gregory C. Copley, Sherif I. Elshahawi, Madan K. Kharel, Larissa V. Ponomareva, Shanteri Singh
Publikováno v:
The Journal of antibiotics
Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocar
Autor:
Karen Marchillo, Maoquan Zhou, Jianjun Zhang, David R. Andes, Larissa V. Ponomareva, Jon S. Thorson
Publikováno v:
Journal of Natural Products. 76:1627-1636
A set of 37 doxycycline neoglycosides were prepared, mediated via a C-9 alkoxyamino-glycyl-based spacer reminiscent of that of tigecycline. Subsequent in vitro antibacterial assays against representative drug-resistant Gram negative and Gram positive