Zobrazeno 41 - 50
of 127
pro vyhledávání: '"Kunhong Xiao"'
Autor:
Vanessa L. Wehbi, Jingming Chen, Masaki Noda, Juan M. Taboas, Kunhong Xiao, Jean-Pierre Vilardaga, Frederic Jean-Alphonse
Publikováno v:
Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2017, 13 (3), pp.259-261. ⟨10.1038/nchembio.2267⟩
Nature Chemical Biology, Nature Publishing Group, 2017, 13 (3), pp.259-261. ⟨10.1038/nchembio.2267⟩
International audience; Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d1de34a5dcf3d2aadc1f153c8610a5
https://hal.archives-ouvertes.fr/hal-03117157
https://hal.archives-ouvertes.fr/hal-03117157
Autor:
Fan Yang, Zheng Gong, Chuan Yong Liu, Mei Jie Wang, Jin-Peng Sun, Amy Lin, Wen Shuai Zheng, Chun-Hua Liu, Zhixin Liu, Yi Jing Wang, Dong Fang He, Fan Yi, Chang Xiu Qu, Chao Ran Ji, Xiao Yu, Thomas J. Cahill, Alex R.B. Thomsen, Kunhong Xiao, Fu Ai Cui, Yu Hong Wang, Zhuan Zhou, Ming-Liang Ma, Peng Xiao, Zong Lai Liang, Alem W. Kahsai, Tian Xue, Yu Jing Sun
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies many fundamental physiological processes. GPCR signalling is negatively regulated by β-arrestins, adaptor molecules that also activate different intracellula
Autor:
Nathan J. Reinert, Yan Xu, Dawei Wang, Peijun Zhang, Tommy S. Tillman, Chuang Liu, Pei Tang, Kunhong Xiao, Frances Joan D. Alvarez
Human Cys-loop receptors are important therapeutic targets. High-resolution structures are essential for rational drug design, but only a few are available due to difficulties in obtaining sufficient quantities of protein suitable for structural stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e3f289545f9d450ea7dc21fcadc487
https://doi.org/10.1074/jbc.m116.729970
https://doi.org/10.1074/jbc.m116.729970
Autor:
Ling-Li Zhang, Jin-Peng Sun, Wei Yao, Hong-Mei Wang, Rong Ma, Kunhong Xiao, Qi Pang, Yuxin Chen, Yu-Jie Du, Yunfei Xu, Shanglei Ning, Duxiao Yang, Lichuan Gu, Xiao Yu, Fan Yang, Yi Li, Cheng-Jiang Gao, Nan Liang, Ya Zhang
Publikováno v:
Cell Research
The tyrosine phosphorylation barcode encoded in C-terminus of HER2 and its ubiquitination regulate diverse HER2 functions. PTPN18 was reported as a HER2 phosphatase; however, the exact mechanism by which it defines HER2 signaling is not fully underst
Autor:
Sachdev S. Sidhu, Brian K. Kobilka, Xin Chen, Li-Yin Huang, Arun K. Shukla, Austin N. Oleskie, Minjung Choi, Sheng Li, Ling Ling Gu, Anthony A. Kossiakoff, Jiang Qian, Gerwin Westfield, Rosana I. Reis, Robert J. Lefkowitz, Shohei Koide, Alem W. Kahsai, Georgios Skiniotis, Jin Ming Shan, Adi Blanc, Prachi Tripathi-Shukla, Pawel A. Penczek, Cui Rong Liang, Rachel Hanna, Anne M. Dosey, Bjoern U. Klink, Xiao Jie Yao, Kunhong Xiao, Min Su, Virgil L. Woods
Publikováno v:
Nature
Single-particle electron microscopy and hydrogen–deuterium exchange mass spectrometry are used to characterize the structure and dynamics of a G-protein-coupled receptor–arrestin complex. Much has been learned about the structure of G-protein-cou
Publikováno v:
Current Opinion in Cell Biology. 27:18-24
The classic paradigm of G protein-coupled receptor (GPCR) activation was based on the understanding that agonist binding to a receptor induces or stabilizes a conformational change to an “active” conformation. In the past decade, however, it has
Autor:
Xiaojie Yao, Dennis J. Thiele, Donita C. Brady, Matthew S. Crowe, G. Aaron Hobbs, Stefan Knapp, Apirat Chaikuad, Michelle L. Turski, Kunhong Xiao, Sharon L. Campbell, Christopher M. Counter
Publikováno v:
Nature
The BRAF kinase is mutated, typically Val 600→Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a smaller extent, a wide spectrum of other cancers. BRAF(V600E) phosphor
Autor:
White, Alex D., Jean-Alphonse, Frederic G., Fei Fang, Peña, Karina A., Shi Liu, König, Gabriele M., Inoue, Asuka, Aslanoglou, Despoina, Gellman, Samuel H., Kostenis, Evi, Kunhong Xiao, Vilardaga, Jean-Pierre
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 3/31/2020, Vol. 117 Issue 13, p7455-7460, 6p
Publikováno v:
Journal of Molecular and Cellular Cardiology. 54:101-111
Cardiac troponin I-interacting kinase (TNNI3K) is a cardiac-specific kinase whose biological function remains largely unknown. We have recently shown that TNNI3K expression greatly accelerates cardiac dysfunction in mouse models of cardiomyopathy, in
Publikováno v:
Circulation Research. 119
During cardiac injury or stress, G protein-coupled receptor (GPCR) kinase 2 (GRK2) expression levels and activity are increased, leading to a desensitization of myocardial β-adrenergic receptors (βARs) and contributing to the loss of contractile re