Zobrazeno 41 - 50
of 117
pro vyhledávání: '"Kiyonaga Fujii"'
Publikováno v:
Journal of Proteomics. 73:1196-1203
Interferon regulatory factor 3 (IRF-3) is a critical transcription factor that regulates innate immune responses against viral infection. Upon infection, IRF-3 is activated through phosphorylation of Ser/Thr residues in its C-terminal domain by the k
Autor:
Sayaka Mikami, Takeshi Kawamura, Hiroko Hamasaki, Harubumi Kato, Toshihide Nishimura, Kiyonaga Fujii, Hiromasa Tojo, Yasuhiko Bando, Masaharu Nomura
Publikováno v:
Journal of Proteomics. 73:1089-1099
We used formalin-fixed paraffin-embedded (FFPE) materials for biomarker discovery in cases of lung cancer using proteomic analysis. We conducted a retrospective global proteomic study in order to characterize protein expression reflecting clinical st
Autor:
Kunihiko Seki, Hisashi Kurosawa, Kazutaka Kikuta, Yasuo Beppu, Tadashi Kondo, Yoshiyuki Suehara, Tadakazu Shimoda, Akira Kawai, Hirokazu Chuman, Tadashi Hasegawa, Setsuo Hirohashi, Robert Nakayama, Hitoshi Ichikawa, Kiyonaga Fujii, Naobumi Tochigi
Publikováno v:
PROTEOMICS - Clinical Applications. 3:623-634
Synovial sarcoma have two histological subtypes, biphasic and monophasic, defined respectively by the presence or absence of glandular epithelial differentiation. To develop histological biomarkers for synovial sarcoma subtypes, we examined the prote
Autor:
Kiyonaga Fujii, Akira Kawai, Yasuhiro Shimada, Yasuo Beppu, Tadashi Kondo, Tatsuhiro Shibata, Setsuo Hirohashi, Hisashi Kurosawa, Tadashi Hasegawa, Kazutaka Kikuta, Takeshi Sano, Kunihiko Seki, Yoshiyuki Suehara, Hitoshi Ichikawa, Tadakazu Shimoda, Masahiro Gotoh, Naobumi Tochigi, Robert Nakayama
Publikováno v:
PROTEOMICS - Clinical Applications. 3:584-596
The gastrointestinal stromal tumor (GIST) is the most common mesenchymal malignancy of the gastrointestinal tract. Its clinical course ranges widely from a curable disorder to a highly malignant disease. Although its clinical and molecular characteri
The Proteomic Profile of Pancreatic Cancer Cell Lines Corresponding to Carcinogenesis and Metastasis
Publikováno v:
Journal of Proteomics & Bioinformatics. :001-018
To investigate the proteomic background of the carcinogenesis and progression of pancreatic cancer, the protein expression profiles of nine well-characterized pancreatic adenocarcinoma cell lines, whose metastatic potential was previously examined in
Autor:
Setsuo Hirohashi, Yoshiyuki Suehara, Kunihiko Seki, Yasuhiro Shimada, Yasuo Beppu, Mitsuru Sasako, Tadashi Kondo, Tadashi Hasegawa, Tadakazu Shimoda, Kiyonaga Fujii, Akira Kawai, Hisashi Kurosawa, Tatsuhiro Shibata, Masahiro Gotoh
Publikováno v:
Clinical Cancer Research. 14:1707-1717
Purpose: We aimed to develop prognostic biomarkers for gastrointestinal stromal tumors (GIST) using a proteomic approach.Experimental Design: We examined the proteomic profile of GISTs using two-dimensional difference gel electrophoresis. The prognos
Autor:
Marie C. South, Hsiao-kun Tu, Masahiro Tsuboi, Ian Peers, Takeshi Kawamura, Fredrik Nyberg, Toshihide Nishimura, Hideo Kunito, Chris Harbron, Shingo Akimoto, Atsushi Ogiwara, Harubumi Kato, Nakata K, Yutaka Kyono, Yutaka Nishiwaki, Mitsuhiro Kanazawa, Tim Higenbottam, Takao Kawakami, Masahiro Fukuoka, György Marko-Varga, Hisae Anyoji, Shuji Hada, Kazuto Nishio, Kiyonaga Fujii, Takashi Hirano, Haiyi Jiang, Shoji Kudoh
Publikováno v:
Journal of Proteome Research. 6:2925-2935
Personalized medicine allows the selection of treatments best suited to an individual patient and disease phenotype. To implement personalized medicine, effective tests predictive of response to treatment or susceptibility to adverse events are neede
Autor:
Takao Itoi, Kiyonaga Fujii, Tadashi Kondo, Tatsuhiko Kakisaka, Setsuo Hirohashi, Tatsuya Aoki, Tesshi Yamada, Toshihide Nishimura, Tetsuya Okano, Mitsufumi Endo, Akihiko Tsuchida, Fuminori Moriyasu, Satoru Todo, Kazufumi Honda, Harubumi Kato
Publikováno v:
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
We investigated the aberrant expression of plasma proteins in patients with pancreatic cancer. High-abundance plasma proteins (albumin, transferrin, haptoglobin, alpha-1-antitrypsin, IgG and IgA) were depleted by use of an immuno-affinity column, and
Autor:
Kiyonaga Fujii, Tetsuya Okano, Yuichiro Ohe, Setsuo Hirohashi, Harbumi Kato, Yoshihiro Matsuno, Koji Tsuta, Tadashi Kondo, Toshimi Takano, Shoji Kudoh, Akihiko Gemma, Toshihide Nishimura
Publikováno v:
Clinical Cancer Research. 13:799-805
Purpose: We aimed to identify candidate proteins for tumor markers to predict the response to gefitinib treatment. Experimental Design: We did two-dimensional difference gel electrophoresis to create the protein expression profile of lung adenocarcin
Autor:
Akito Nishizawa, Kiyonaga Fujii, Makoto Shirai, Tomoyasu Nishizawa, Ken-ichi Harada, Tomoyo Nakano, Arizal Bin Arshad, Munehiko Asayama
Publikováno v:
The Journal of General and Applied Microbiology. 53:17-27
Two nonribosomal peptide synthetase genes responsible for the biosynthesis of microcystin and micropeptin in Microcystis aeruginosa K-139 have been identified. A new nonribosomal peptide synthetase gene, psm3, was identified in M. aeruginosa K-139. T