Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Khalid M. El-Say"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2640 (2023)
Rosuvastatin (RSV) is a widely used cholesterol-lowering medication, but its limited bioavailability due to its susceptibility to stomach pH and extensive first-pass metabolism poses a significant challenge. A fast-dissolving film (FDF) formulation o
Externí odkaz:
https://doaj.org/article/4b5be52034934b2499cc18085d08c30c
Autor:
Tarek A. Ahmed, Alshaimaa M. Almehmady, Waleed S. Alharbi, Abdullah A. Alshehri, Fahad A. Almughem, Reem M. Altamimi, Manal A. Alshabibi, Abdelsattar M. Omar, Khalid M. El-Say
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2771 (2023)
Perillyl alcohol (PA), a naturally existing monocyclic terpene related to limonene, is characterized by its poor aqueous solubility and very limited bioavailability. Its potential anti-cancer activity against malignant glioma has been reported. The a
Externí odkaz:
https://doaj.org/article/8772f0171a734dba87426fd414c35a7e
Autor:
Tarek A. Ahmed, Ehab M. M. Ali, Abdulaziz A. Kalantan, Alshaimaa M. Almehmady, Khalid M. El-Say
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1901 (2023)
6-Mercaptopurine (6-MP) is a chemotherapeutic agent with inadequate efficacy due to its poor aqueous solubility and limited bioavailability. Turmeric oil is a naturally occurring bioactive substance obtained from the rhizomes of Curcuma longa Linn th
Externí odkaz:
https://doaj.org/article/27f8fb4a43c84fc88f253386859fdd6b
Autor:
Mohamed F. Zaky, Mohamed A. Megahed, Taha M. Hammady, Shadeed Gad, Mamdouh Mostafa Ghorab, Khalid M. El-Say
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 80 (2022)
Apixaban (Apx), an oral anticoagulant drug, is a direct factor Xa inhibitor for the prophylaxis against venous thromboembolism. Apx has limited oral bioavailability and poor water solubility. The goal of this study was to improve the formulation of a
Externí odkaz:
https://doaj.org/article/6405b0c884324bf09cbab0b622bee553
Autor:
Alshaimaa M. Almehmady, Khalid M. El-Say, Manal A. Mubarak, Haneen A. Alghamdi, Njood A. Somali, Alaa Sirwi, Rahmah Algarni, Tarek A. Ahmed
Publikováno v:
Polymers, Vol 15, Iss 1, p 209 (2022)
Fungal eye infections are caused mainly by an eye injury and can result in serious eye damage. Fluconazole (FLZ), a broad-spectrum antifungal agent, is a poorly soluble drug with a risk of hepatotoxicity. This work aimed to investigate the antifungal
Externí odkaz:
https://doaj.org/article/eb55c5b1097546f580b6affe8d244cb0
Autor:
Maan T. Khayat, Abdelsattar M. Omar, Mahmoud A. Elfaky, Yosra A. Muhammad, Elaf A. Felemban, Khalid M. El-Say, Moustafa E. El-Araby
Publikováno v:
Heteroatom Chemistry, Vol 2022 (2022)
Chronic Hepatitis C is a global health threat and a silent killer. Regardless of the profound progress in preventing and treating this disease, research continues to discover new direct antiviral agents (DAAs), especially against novel targets. Our r
Externí odkaz:
https://doaj.org/article/320200ef08d44feba563a7dac4ce48f5
Publikováno v:
ACS Omega, Vol 5, Iss 25, Pp 15476-15486 (2020)
Externí odkaz:
https://doaj.org/article/c74a8801f88a47bda1acd37a8f8fba6d
Publikováno v:
Nanomaterials, Vol 12, Iss 22, p 3966 (2022)
The development of an oral anti-diabetic medication characterized by enhanced hypoglycemic activity is in high demand. The goal was to study the hypoglycemic activity and pancreatic histopathology after the black-seed-based self-nanoemulsifying drug
Externí odkaz:
https://doaj.org/article/22ef2cd201e74dbaa57b61c619b8f00b
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 68 (2022)
Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study the
Externí odkaz:
https://doaj.org/article/ba7d507bc5ea4f76a675cef4339b5236
Autor:
Tahani S. Basahih, Abdullah A. Alamoudi, Khalid M. El-Say, Nabil A. Alhakamy, Osama A. A. Ahmed
Publikováno v:
Dose-Response, Vol 18 (2020)
Glimepiride (GMD) is a hypoglycemic agent that has variation in bioavailability for its unexpected absorption. Glimepiride was formulated in a buccal film loaded with a nanobased formulation to enhance its absorption via buccal mucosa. Nanostructured
Externí odkaz:
https://doaj.org/article/5089b3bcf7054bad91609ebddae08ead