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pro vyhledávání: '"Kevin D. Moeller"'
Autor:
Kevin D. Moeller
Publikováno v:
Tetrahedron. 56:9527-9554
Publikováno v:
Tetrahedron. 56:10113-10125
In connection with efforts to build constrained peptidomimetics for the endocrine hormone TRH, a general strategy for the construction of bicyclic lactam peptide building blocks has been developed. This strategy used an anodic amide oxidation to sele
Autor:
Wenhua Chu, Kevin D. Moeller
Publikováno v:
Tetrahedron Letters. 40:7939-7943
A strategy for constructing bicyclic lactam amino acid building blocks with imidazole sidechains is reported. The synthetic route described utilizes an electrochemical amide oxidation to functionalize a proline derivative, and then a sequential cycli
Intramolecular anodic olefin coupling reactions: The construction of bridged bicyclic ring skeletons
Publikováno v:
Tetrahedron Letters. 39:8027-8030
Intramolecular anodic olefin coupling reactions have been used to construct both bicyclo[3.2.1]octane and bicyclo[2.2.1]heptane ring systems. The effect of substituents on the stereochemistry about the newly generated carbon-carbon bond was examined.
Autor:
Laura M. Beal, Kevin D. Moeller
Publikováno v:
Tetrahedron Letters. 39:4639-4642
A sequential electrochemical amide oxidation - ring closing olefin metathesis sequence has been used to overcome problems associated with the synthesis of seven-membered ring lactam containing bicyclic peptidomimetics. The synthesis of several previo
Publikováno v:
Magnetic Resonance in Chemistry. 35:267-272
The stereochemistry and conformation of a key bicyclic lactam-based Leu–Pro building block and the conformation of the surrounding peptide fragment were assigned using a combination of 2D-NOE data and coupling constants from an NMR simulation. The
Publikováno v:
Electrochimica Acta. 42:1967-1970
The study of intramolecular anodic olefin coupling reactions arising from diene substrates having an allylic alkoxy group have been studied. In all cases, the coupling reactions proceeded smoothly without elimination of the allylic alkoxy group. In a
Autor:
Jun Tian, Kevin D. Moeller
Publikováno v:
Organic Letters. 7:5381-5383
[reaction: see text] During efforts to develop chip-based Heck reaction chemistry, it was discovered that normal solution-phase Heck reactions can be dramatically accelerated using electrochemistry. The acceleration makes room temperature Heck reacti
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 1630-1636 (2013)
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 1630-1636 (2013)
Carboxylic acids have been electro-oxidatively coupled to electron-rich olefins to form lactones. Kolbe decarboxylation does not appear to be a significant competing pathway. Experimental results indicate that oxidation occurs at the olefin and that
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:315-318
A facile route for the synthesis of peptide building blocks that constrain the peptide backbone with a 1,4-diazabicyclo[4.3.0]nonane ring skeleton is reported. The synthesis employed an anodic amide oxidation based approach for generating a functiona