Zobrazeno 61 - 70
of 159
pro vyhledávání: '"Kenneth J. Livak"'
Autor:
Daniel J. DeAngelo, Alexandria K Maurer, Vijay G. Sankaran, Catherine J. Wu, Robert J. Soiffer, Caleb A. Lareau, Jacqueline S. Garcia, Livius Penter, Nicoletta Cieri, Jackson Southard, Donna Neuberg, Kenneth J. Livak, Shuqiang Li, Srinika Ranasinghe, Leif S. Ludwig
Publikováno v:
Blood. 138:1689-1689
Reconstitution of donor hematopoiesis after allogeneic hematopoietic stem cell transplantation (HSCT) forms the basis for effective graft-versus-leukemia responses, but mixed chimerism is not an infrequent outcome. How the donor and host hematopoieti
Autor:
Giacomo Oliveira, Moshe Sade-Feldman, Derin B. Keskin, Megan Wind-Rotolo, Edward F. Fritsch, Kenneth J. Livak, Scott J. Rodig, Genevive Boland, Dennie Tompers, David A. Braun, Bryan Iorgulescu, Patrick A. Ott, Shuqiang Li, Donna Neuberg, Steven A. Carr, Catherine J. Wu, Susan Klaeger, Kari Stromhaug, Nir Hacohen, Nicoletta Cieri
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A684-A684
BackgroundWithin the tumor microenvironment, distinct CD4+ T cell subsets can play different and even opposite roles either promoting or suppressing anti-tumor responses through the recognition of antigens presented by human leukocyte antigen (HLA) c
Autor:
Nicoletta Cieri, Donna Neuberg, Shuqiang Li, Neil G. Ruthen, Dana Pe'er, Haesook T. Kim, Christina Ennis, Robert J. Soiffer, Jerome Ritz, Cameron Y. Park, Zhongqi Ge, Vinhkhang N Nguyen, Katie Maurer, Zi-Ning Choo, Pavan Bachireddy, Edwin P. Alyea, Satyen H. Gohil, Derin B. Keskin, Cassandra Burdziak, Kenneth J. Livak, Elham Azizi, Catherine J. Wu
Publikováno v:
Cell Rep
Summary To elucidate mechanisms by which T cells eliminate leukemia, we study donor lymphocyte infusion (DLI), an established immunotherapy for relapsed leukemia. We model T cell dynamics by integrating longitudinal, multimodal data from 94,517 bone
Autor:
Gad Getz, Eugen Tausch, Matthew S. Davids, Stacey M. Fernandes, Jennifer R. Brown, Aina Zurita Martinez, Neil E. Kay, Florence Cymbalista, Laxmi Parida, Filippo Utro, William G. Wierda, Sameer A. Parikh, Christof Schneider, Kahn Rhrissorrakrai, Bria Persaud, Stephan Stilgenbauer, Nitin Jain, Donna Neuberg, Julien Broséus, Chaya Levovitz, Daniel Rosebrock, Liudmila Elagina, Annabelle J. Anandappa, Camilla Koldbæk Lemvigh, Romain Guieze, Ignaty Leshchiner, Amaro Taylor-Weiner, Thomas J. Kipps, Erin M. Parry, Brian P. Danysh, Teddy Huang, Kara Slowik, Kenneth J. Livak, Johannes Bloehdorn, Noelia Purroy, Catherine J. Wu, Laura Z. Rassenti, Shuqiang Li
Publikováno v:
Blood. 136:47-48
Richter's syndrome (RS) arising from chronic lymphocytic leukemia (CLL) is a striking example of an aggressive malignant histology that emerges from indolent cancer. A major barrier to disease control in CLL, RS is associated with poor clinical outco
Autor:
Wandi Zhang, Srinika Ranasinghe, Donna Neuberg, Kenneth J. Livak, Jerome Ritz, Robert J. Soiffer, Livius Penter, Yi Zhang, Satyen H. Gohil, Shuqiang Li, Teddy Huang, Haesook T. Kim, Pavan Bachireddy, Robert Zeiser, Nicoletta Cieri, Alexandra Savell, X. Shirley Liu, Catherine J. Wu, Matthew S. Davids
Publikováno v:
Blood. 136:34-35
Relapse after allogeneic hematopoietic stem cell transplantation (HSCT) remains an unmet medical need. The ETCTN 9204 study evaluated in 71 study subjects if immune checkpoint blockade with anti-CTLA-4 (Ipilimumab (Ipi), n = 43) or anti-PD-1 (Nivolum
Autor:
Lili Wang, Elisa Ten Hacken, Elizabeth Witten, Catherine J. Wu, Shuqiang Li, Kaitlyn Baranowski, Donna Neuberg, Geoffrey Fell, Robert A. Redd, Michaela Gruber, Luca Pinello, Leah Billington, Mohamed Uduman, Ruben D. Carrasco, Tomasz Sewastianik, Erin M. Parry, María Hernández-Sánchez, Shanye Yin, Kendell Clement, Kenneth J. Livak
Publikováno v:
Blood. 136:2-3
Although we have gained a wealth of knowledge from large-scale DNA sequencing studies across blood cancers, we still know little about the functional interplay of the discovered putative drivers in the generation of chronic lymphocytic leukemia (CLL)
Autor:
Anat Biran, Blake Tye, Fara Faye Regis, Aviv Liani, Elisa Ten Hacken, Lili Wang, Binyamin A. Knisbacher, Mei Zheng, Leah Billington, Peyton Waddicor, Aviv Regev, Kenneth J. Livak, María Hernández-Sánchez, Shuqiang Li, Catherine Gutierrez, Gad Getz, Heather Joyal, Donna Neuberg, Ruben D. Carrasco, Florence Cymbalista, Ziao Lin, Stirling Churchman, Sichen Shao, Fabienne Lucas, Elizabeth Witten, Miguel Quijada Álamo, Tamara Ouspenskaia, Aziz Al'Khafaji, Catherine J. Wu, Gregory Lazarian, Doris Fu
Publikováno v:
Blood. 136:28-29
Amongst the novel putative drivers identified by large-scale sequencing studies of chronic lymphocytic leukemia (CLL) is the ribosomal protein RPS15. Mutated in 5.3% of CLL, it co-occurs with heterozygous TP53 alterations in 36% of RPS15-mutated samp
Autor:
Gabrielle Bouchard, Wenxin Xu, David L. Cookmeyer, Bradley Alexander McGregor, Kelly Street, Ziad Bakouny, Arlene H. Sharpe, Christina B. Pedersen, Lucas Pomerance, Nicholas Schindler, Sachet A. Shukla, Erica Maria Pimenta, Rafael A. Irizarry, Kathleen M. Mahoney, John A. Steinharter, Ang Cui, Kelly P. Burke, Juliet Forman, Steven L. Chang, Michelle S. Hirsch, Maxine Sun, Catherine J. Wu, Lars Rønn Olsen, Sabina Signoretti, David A. Braun, Derin B. Keskin, Toni K. Choueiri, Kenneth J. Livak, Shuqiang Li, Yue Hou, David F. McDermott, Satyen H. Gohil, Teddy Huang, Laure Hirsch, Thomas Denize
Publikováno v:
Cancer Cell
The tumor immune microenvironment plays a critical role in cancer progression and response to immunotherapy in clear cell renal cell carcinoma (ccRCC), yet the composition and phenotypic states of immune cells in this tumor are incompletely character
Autor:
Donna Neuberg, Shuqiang Li, Jerome Ritz, Christina Ennis, Edwin P. Alyea, Robert J. Soiffer, Dana Pe'er, Vinhkhang N Nguyen, Kenneth J. Livak, Catherine J. Wu, Pavan Bachireddy, Cassandra Burdziak, Zi Ning Choo, Elham Azizi
Publikováno v:
Cancer Research. 81:LT008-LT008
Immune therapies have transformed the cancer therapeutic landscape but fail to benefit most patients. To elucidate the underlying mechanisms by which T cells mediate elimination of leukemia, we generated a high-resolution map of longitudinal T cell d
Autor:
W. Reef Hardy, Chirayu P. Goswami, Leni Moldovan, Krishnalekha Datta, Bruno Péault, Mirko Corselli, Iain R. Murray, Keith L. March, Kenneth J. Livak, Dmitry O. Traktuev, Nicanor I. Moldovan
Publikováno v:
Stem Cells. 35:1273-1289
Adipose tissue is a rich source of multipotent mesenchymal stem-like cells, located in the perivascular niche. Based on their surface markers, these have been assigned to two main categories: CD31−/CD45−/CD34+/CD146− cells (adventitial stromal/