Zobrazeno 11 - 20
of 137
pro vyhledávání: '"Kelly A. Whelan"'
Autor:
Yuta Kasagi, Prasanna M. Chandramouleeswaran, Kelly A. Whelan, Koji Tanaka, Veronique Giroux, Medha Sharma, Joshua Wang, Alain J. Benitez, Maureen DeMarshall, John W. Tobias, Kathryn E. Hamilton, Gary W. Falk, Jonathan M. Spergel, Andres J. Klein-Szanto, Anil K. Rustgi, Amanda B. Muir, Hiroshi Nakagawa
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 333-352 (2018)
Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids is needed to stud
Externí odkaz:
https://doaj.org/article/21163af81d7441fbb6e128ef99587eeb
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 461-478 (2018)
The stratified squamous epithelium of the esophagus shows a proliferative basal layer of keratinocytes that undergo terminal differentiation in overlying suprabasal layers. Esophageal pathologies, including eosinophilic esophagitis, gastroesophageal
Externí odkaz:
https://doaj.org/article/257d2b8d957947399b24e2589d1919fd
Autor:
Mitsuteru Natsuizaka, Kelly A. Whelan, Shingo Kagawa, Koji Tanaka, Veronique Giroux, Prasanna M. Chandramouleeswaran, Apple Long, Varun Sahu, Douglas S. Darling, Jianwen Que, Yizeng Yang, Jonathan P. Katz, E. Paul Wileyto, Devraj Basu, Yoshiaki Kita, Shoji Natsugoe, Seiji Naganuma, Andres J. Klein-Szanto, J. Alan Diehl, Adam J. Bass, Kwok-Kin Wong, Anil K. Rustgi, Hiroshi Nakagawa
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Notch receptors can exert different roles in cancer. In this manuscript, the authors reveal that Notch1 activation and EMT promote tumor initiation and cancer cell heterogeneity in squamous cell carcinoma, while the repression of Notch3 by ZEB1 limit
Externí odkaz:
https://doaj.org/article/6f8691ad6d324ab0a967f60181be89c5
Autor:
Monica M. Laronda, Alexandra L. Rutz, Shuo Xiao, Kelly A. Whelan, Francesca E. Duncan, Eric W. Roth, Teresa K. Woodruff, Ramille N. Shah
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
There is a clinical need to develop a bioengineering system to support ovary transplantation. Here, the authors generate a bioprosthetic ovary using 3D printed scaffolds of varying pore architectures to support follicle survival and ovarian function
Externí odkaz:
https://doaj.org/article/ed4e6fb742f8483e95d3188f3e2e4887
Autor:
Reshu Saxena, Alena Klochkova, Mary Grace Murray, Mohammad Faujul Kabir, Safiyah Samad, Tyler Beccari, Julie Gang, Kishan Patel, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cancers, Vol 11, Iss 11, p 1697 (2019)
Esophageal cancer is among the most aggressive forms of human malignancy with five-year survival rates of
Externí odkaz:
https://doaj.org/article/c5135756dbd14edfac8c4c10d50af5f7
Autor:
Patrick A. Williams, Kaitlyn E. Naughton, Lauren A. Simon, Gloria E. Soto, Louis R. Parham, Xianghui Ma, Charles H. Danan, Weiming Hu, Elliot S. Friedman, Emily A. McMillan, Hritik Mehta, Madison A. Stoltz, Joshua Soto Ocaña, Joseph P. Zackular, Kyle Bittinger, Kelly A. Whelan, Tatiana A. Karakasheva, Kathryn E. Hamilton
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G354-G368
Calorie restriction is associated with enhanced intestinal regeneration after irradiation, but the requirement of autophagy for this process is not known. Our data support the premise that intestinal epithelial autophagy is required for the regenerat
Autor:
Mohammad Faujul Kabir, Jazmyne L Jackson, Annie D Fuller, Leonny Gathuka, Adam L Karami, Don-Gerard Conde, Alena Klochkova, Anbin Mu, Kathy Q Cai, Andres J Klein-Szanto, Amanda B Muir, Kelly A Whelan
Publikováno v:
Carcinogenesis. 44:182-195
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of human malignancy, often displaying limited therapeutic response. Here, we examine the non-steroidal anti-inflammatory drug diclofenac (DCF) as a novel therapeutic agent
Autor:
Qian Guo, Mingyang Xin, Qingchun Lu, Dechun Feng, Vicky Yang, Lee F. Peng, Kelly A. Whelan, Wenhui Hu, Sheng Wu, Xiaofeng Yang, Hong Wang, Brad S. Rothberg, Ana M. Gamero, Glenn S. Gerhard, Bin Gao, Ling Yang
Publikováno v:
Theranostics. 13:2210-2225
Autor:
Margarette H. Clevenger, Adam L. Karami, Dustin A. Carlson, Peter J. Kahrilas, Nirmala Gonsalves, John E. Pandolfino, Deborah R. Winter, Kelly A. Whelan, Marie-Pier Tétreault
Publikováno v:
bioRxiv
Eosinophilic esophagitis (EoE) is an esophageal immune-mediated disease characterized by eosinophilic inflammation and epithelial remodeling, including basal cell hyperplasia (BCH) and loss of differentiation. Although BCH correlates with disease sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1182d61b4a7c6199734943cf7cb51562
https://europepmc.org/articles/PMC10153277/
https://europepmc.org/articles/PMC10153277/
Autor:
Takeshi Kurita, Teresa K. Woodruff, Adrian A. Suarez, Kelly A. Whelan, Megan M. Romero, Marilia H. Cordeiro, Katherine Ebbert, So-Youn Kim
Gross morphology (A) and histology (B) of GCT grafts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397af4c8380ceab0ed7ea473c39857f5
https://doi.org/10.1158/0008-5472.22411481.v1
https://doi.org/10.1158/0008-5472.22411481.v1