Zobrazeno 81 - 90
of 108
pro vyhledávání: '"Kehao Zhao"'
Autor:
Kehao Zhao, Ho Man Chan, Haiping Wu, Justin Gu, Jun Liu, Peter Atadja, Jingquan Dai, En Li, Qian Li, Feng Yan, Min Hu, Yan Wang, Zhaofu Wang, Jing Wu, Chris Lu, Youzhen Wang, Zheng Huang, Ming Fang, Xu Wu, Nathan P. Englund, Fiona Xu, Shannon Chuai, Man Zhang, Hailong Zhang, Wei Yi, Shaolian Zhou, Yanyan Yu, Teddy Yang
Publikováno v:
Cancer research. 73(20)
Histone lysine methyltransferase NSD2 (WHSC1/MMSET) is overexpressed frequently in multiple myeloma due to the t(4;14) translocation associated with 15% to 20% of cases of this disease. NSD2 has been found to be involved in myelomagenesis, suggesting
Autor:
Kaniskan, H. Ümit, Eram, Mohammad S., Kehao Zhao, Szewczyk, Magdalena M., Xiaobao Yang, Xiao Luo, Sean Xiao, Miao Dai, Feng He, Irene Zang, Ying Lin, Fengling Li, Dobrovetsky, Elena, Smil, David, Sun-Joon Min, Lin-Jones, Jennifer, Schapira, Matthieu, Atadja, Peter, En Li, Barsyte-Lovejoy, Dalia
Publikováno v:
Journal of Medicinal Chemistry; 2/8/2018, Vol. 61 Issue 3, p1204-1217, 14p
Autor:
Grace Feng, Jue Zeng, Xianghui Liu, Ophelia Ardayfio, Jialuo Fang, Min Li, Zhengtian Yu, Peter Atadja, Ying Lin, Zijun Chen, En Li, Wei Qi, Chris Lu, Justin Gu, Guobin Li, Kehao Zhao, Lin Teng, Yuan Mi, Xiaoxia Yan, Hong Fan, Shannon Chuai, Ho Man Chan, Teddy T.C. Yang, Man Zhang, Tao Zhou, Ji-Hu Zhang, Ling Li, Ruipeng Zhang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(52)
Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation and differentiation dur
Autor:
Chris Lu, Peter Atadja, Justin Gu, En Li, Hailong Zhang, Ling Li, Shaolian Zhou, Jingquan Dai, Li Wang, Xiao Luo, Kehao Zhao, Jidong Zhu
Publikováno v:
The Journal of biological chemistry. 286(44)
SMYD2 belongs to a subfamily of histone lysine methyltransferase and was recently identified to methylate tumor suppressor p53 and Rb. Here we report that SMYD2 prefers to methylate p53 Lys-370 over histone substrates in vitro. Consistently, the leve
Autor:
Walter Rocha, Alain Verrault, Marlene Gharib, Katrina Meeth, Marc A. Holbert, Ronen Marmorstein, Philip A. Cole, Xin Liu, Cheng Luo, Pierre Thibault, Eva Jiang, Ling Wang, Hugo Wurtele, Kehao Zhao, Yong Tang
Publikováno v:
The FASEB Journal. 23
Autor:
Lisa C. Gibson, Allan D. Capili, David W. Speicher, Ronen Marmorstein, Kehao Zhao, Katherine L. B. Borden, Sandra L. Harper, Frank J. Rauscher, Thomas A. Rock, Michael J. Osborne, Hongzhuang Peng
Publikováno v:
Journal of molecular biology. 370(2)
The KRAB domain is a 75 amino acid transcriptional repression module that is encoded by more than 400 zinc finger protein genes, making it the most abundant repression domain in the human proteome. KRAB-mediated gene silencing requires a direct high
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 62(Pt 12)
The p53 transcriptional regulator is the most frequently mutated protein in human cancers and the majority of tumor-derived p53 mutations map to the central DNA-binding core domain, with a subset of these mutations resulting in reduced p53 stability.
Autor:
Kehao Zhao, Jeffrey Lenkart, Ronen Marmorstein, Ramin Shiekhattar, Guoping Da, Bradley R. Cairns
The SWIRM domain is a module found in the Swi3 and Rsc8 subunits of SWI/SNF-family chromatin remodeling complexes, and the Ada2 and BHC110/LSD1 subunits of chromatin modification complexes. Here we report the high-resolution crystal structure of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd011b0dee0d8be5a9f283156f596af
https://europepmc.org/articles/PMC1413740/
https://europepmc.org/articles/PMC1413740/
Autor:
Ronen Marmorstein, Kehao Zhao
Publikováno v:
Histone Deacetylases ISBN: 9781588294999
Sir2 enzymes are broadly conserved from bacteria to humans, and eukaryotic organisms typically contain multiple Sir2 enzymes that target different protein substrates to mediate diverse biological processes including gene silencing, DNA repair, genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49aeb614e04935d985e631890f790e6f
https://doi.org/10.1385/1-59745-024-3:203
https://doi.org/10.1385/1-59745-024-3:203
Autor:
Ying Huang, Jeff Zhang, Zhengtian Yu, Hailong Zhang, Youzhen Wang, Lingel, Andreas, Wei Qi, Justin Gu, Kehao Zhao, Shultz, Michael D., Long Wang, Xingnian Fu, Yongfeng Sun, Qiong Zhang, Xiangqing Jiang, Jiangwei Zhang, Chunye Zhang, Ling Li, Jue Zeng, Lijian Feng
Publikováno v:
Journal of Medicinal Chemistry; 3/23/2017, Vol. 60 Issue 6, p2215-2226, 12p