Zobrazeno 41 - 50
of 56
pro vyhledávání: '"Katsuhito Nagai"'
Autor:
Sadaki Fujimoto, Kentaro Nishida, Katsuhito Nagai, Hiroto Okuda, Miho Niitani, Kazuki Nagasawa
Publikováno v:
International journal of pharmaceutics. 388(1-2)
Concentrative nucleoside transporter 1 (CNT1, SLC28A1) is a key molecule for determining the pharmacokinetic/pharmacodynamic profile of a candidate compound derived from a pyrimidine nucleoside, but there is no available information on the difference
Publikováno v:
International journal of pharmaceutics. 333(1-2)
Various antimetabolites of nucleobase analogues, such as 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and 5-fluorouracil (5-FU), are used for cancer treatments. The first step in nucleobase analogue drug therapy is entry of these compounds into tumo
Publikováno v:
Biochemical and biophysical research communications. 347(2)
Nucleoside transporter (NT) plays key roles in the physiology of nucleosides and the pharmacology of its analogues in mammals. We previously cloned Na+/nucleoside cotransporter CNT2 from mouse M5076 ovarian sarcoma cells, the peptide encoded by it di
Publikováno v:
Neuroscience letters. 407(3)
Endogenous adenine is an important modulator of cell survival and activity in the central nervous system. In the present study, we examined the transport mechanisms for adenine in primary cultured rat cortical neurons and astrocytes. [3H]Adenine was
Autor:
Shun Shimohama, Kazuki Nagasawa, Mineto Koma, Taichi Kakuda, Katsuhito Nagai, Sadaki Fujimoto, Junya Akagi
Publikováno v:
Life sciences. 79(1)
Aluminum (Al) is thought to be a risk factor for neurodegenerative disorders, but the molecular mechanism has been not clarified yet. In this study, we examined how a transport system handled transport of Al citrate, the major Al species in brain, an
Publikováno v:
Biochemical pharmacology. 71(5)
In the present study, we investigated whether an unidentified system for Na(+)-dependent nucleoside transport is expressed by mouse M5076 ovarian sarcoma cells, besides concentrative nucleoside transporter 2 (CNT2(M)), and is involved in the uptake a
Publikováno v:
Archives of biochemistry and biophysics. 438(2)
Cytochalasin D (CD) induced production of the superoxide radical ( O 2 − ) in guinea pig polymorphonuclear leukocytes (PMNs). The protein kinase C (PKC) inhibitor GF109203X (GFX) was rarely without effect on CD-induced O 2 − production. CD as wel
Autor:
Shingo Ito, Katsuhito Nagai, Ikumi Tamai, Kazuki Nagasawa, Sadaki Fujimoto, Taichi Kakuda, Akira Tsuji
Publikováno v:
Toxicology letters. 155(2)
Although accumulation of aluminum (Al) in the brain is known to cause neurodegenerative disorders and to be regulated mainly by the blood-brain barrier (BBB), the mechanism responsible for Al transport at the BBB has not been clarified yet. In this s
Autor:
Noriaki Ohnishi, Yuji Sumitani, Yuka Moriya, Kazuki Nagasawa, Katsuhito Nagai, Yuichi Muraki, Kohji Takara, Teruyoshi Yokoyama, Sadaki Fujimoto
Publikováno v:
Journal of pharmaceutical sciences. 91(12)
To clarify the uptake mechanism(s) for statins, we examined whether monocarboxylate transporter (MCT) contributed to the uptake of lovastatin acid by rat cultured mesangial cells. Expression of mRNAs for MCT1, 2, and 4 was confirmed in mesangial cell
Publikováno v:
Cancer chemotherapy and pharmacology. 51(6)
We evaluated the contribution of a nucleoside transporter (NT) consisting of an equilibrative NT (ENT) and a concentrative Na(+)/nucleoside cotransporter (CNT) to the uptake of THP and DOX by mouse Ehrlich ascites carcinoma cells. METHODS. Transport