Zobrazeno 11 - 20
of 418
pro vyhledávání: '"Katia Scotlandi"'
Autor:
Georgia Zoumpoulidou, Carlos Alvarez-Mendoza, Caterina Mancusi, Ritika-Mahmuda Ahmed, Milly Denman, Christopher D. Steele, Maxime Tarabichi, Errin Roy, Lauren R. Davies, Jiten Manji, Camilla Cristalli, Katia Scotlandi, Nischalan Pillay, Sandra J. Strauss, Sibylle Mittnacht
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
RB1 mutations are seen in 40-60% of sporadic osteosarcoma. Here, the authors demonstrate a selective sensitivity to PARP inhibitors in RB1-mutated osteosarcoma-derived cell lines that is not associated with canonical signatures indicative of a homolo
Externí odkaz:
https://doaj.org/article/29d2b65339524853a5548dbf68b35ca4
Publikováno v:
Cancers, Vol 15, Iss 15, p 3887 (2023)
Synovial sarcoma (SyS) is a rare aggressive soft tissue sarcoma carrying the chromosomal translocation t(X;18), encoding the fusion transcript SS18::SSX. The fusion oncoprotein interacts with both BAF enhancer complexes and polycomb repressor complex
Externí odkaz:
https://doaj.org/article/770d7178a08d4b129e5f3186d13a2d50
Autor:
Marcella Martinelli, Caterina Mancarella, Luca Scapoli, Annalisa Palmieri, Paola De Sanctis, Cristina Ferrari, Michela Pasello, Cinzia Zucchini, Katia Scotlandi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Ewing sarcoma (EWS), the second most common malignant bone tumor in children and adolescents, occurs abruptly without clear evidence of tumor history or progression. Previous association studies have identified some inherited variants associated with
Externí odkaz:
https://doaj.org/article/6c93665eb071432c98f9d047c591bada
Autor:
Camilla Cristalli, Maria Cristina Manara, Sergio Valente, Evelin Pellegrini, Alberto Bavelloni, Alessandra De Feo, William Blalock, Elisabetta Di Bello, David Piñeyro, Angelika Merkel, Manel Esteller, Oscar M. Tirado, Antonello Mai, Katia Scotlandi
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
DNA methylation is an important component of the epigenetic machinery that regulates the malignancy of Ewing sarcoma (EWS), the second most common primary bone tumor in children and adolescents. Coordination of DNA methylation and DNA replication is
Externí odkaz:
https://doaj.org/article/72d7fec2ed6148faa9ae41cddd9e0221
Autor:
Sara Salucci, Alberto Bavelloni, Anna Bartoletti Stella, Francesco Fabbri, Ivan Vannini, Manuela Piazzi, Karyna Volkava, Katia Scotlandi, Giovanni Martinelli, Irene Faenza, William Blalock
Publikováno v:
Nutrients, Vol 15, Iss 3, p 740 (2023)
Approximately 7% of cancers arising in children and 1% of those arising in adults are soft tissue sarcomas (STS). Of these malignancies, rhabdomyosarcoma (RMS) is the most common. RMS survival rates using current therapeutic protocols have remained l
Externí odkaz:
https://doaj.org/article/e99582ac5bd0418ab61d25475859f42a
Publikováno v:
Cancers, Vol 15, Iss 3, p 588 (2023)
Synovial sarcomas (SyS) are rare malignant tumors predominantly affecting children, adolescents, and young adults. The genetic hallmark of SyS is the t(X;18) translocation encoding the SS18-SSX fusion gene. The fusion protein interacts with both the
Externí odkaz:
https://doaj.org/article/3bbf41d763f04e64a5de3c24cd4e8306
Autor:
Claudia Maria Hattinger, Iris Chiara Salaroglio, Leonardo Fantoni, Martina Godel, Chiara Casotti, Joanna Kopecka, Katia Scotlandi, Toni Ibrahim, Chiara Riganti, Massimo Serra
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 799 (2023)
Improving the prognosis and cure rate of HGOSs (high-grade osteosarcomas) is an absolute need. Immune-based treatment approaches have been increasingly taken into consideration, in particular for metastatic, relapsed and refractory HGOS patients, to
Externí odkaz:
https://doaj.org/article/acab637ac1c04879ad0704f703ee7abb
Autor:
Maria Teresa Di Martino, Stefania Meschini, Katia Scotlandi, Chiara Riganti, Enrico De Smaele, Francesca Zazzeroni, Massimo Donadelli, Carlo Leonetti, Michele Caraglia
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-11 (2020)
Abstract Molecular profiling of DNA and RNA has provided valuable new insights into the genetic basis of non-malignant and malignant disorders, as well as an increased understanding of basic mechanisms that regulate human disease. Recent technologica
Externí odkaz:
https://doaj.org/article/9de877396e9b457095db2f29af5d3a24
Autor:
Cinzia Zucchini, Maria Cristina Manara, Camilla Cristalli, Marianna Carrabotta, Sara Greco, Rosa Simona Pinca, Cristina Ferrari, Lorena Landuzzi, Michela Pasello, Pier-Luigi Lollini, Marco Gambarotti, Davide Maria Donati, Katia Scotlandi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background The treatment of metastatic osteosarcoma (OS) remains a challenge for oncologists, and novel therapeutic strategies are urgently needed. An understanding of the pathways that regulate OS dissemination is required for the design of
Externí odkaz:
https://doaj.org/article/5cd4ab50637442cbb9538299c71ce2ac
Publikováno v:
Cancers, Vol 14, Iss 21, p 5411 (2022)
Capicua transcriptional repressor (CIC)-rearranged sarcoma, belonging to the undifferentiated round cells sarcoma family, is characterized by high metastatic rate and poor chemo response. CIC sarcoma represents a new entity harboring the recurrent ch
Externí odkaz:
https://doaj.org/article/142d1f80bc234ae4bd12b512d18c1211