Zobrazeno 91 - 100
of 369
pro vyhledávání: '"Karin B. Michels"'
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
The intrauterine and early life environments have been linked to the etiology of breast cancer in prior studies. We prospectively examined whether maternal and newborn anthropometric factors as reported by the mother are related to an increased incid
Autor:
Dominique Scherer, Melanie Boerries, Alexis Ulrich, Esther Herpel, Cornelia M. Ulrich, Biljana Gigic, Yesilda Balavarca, Hauke Busch, Hagen Klett, Reka Toth, Petra Schrotz-King, Peter Schirmacher, Hermann Brenner, Karin B. Michels, Nina Habermann
Publikováno v:
Epigenetics. 13:386-397
DNA methylation is recognized as one of several epigenetic regulators of gene expression and as potential driver of carcinogenesis through gene-silencing of tumor suppressors and activation of oncogenes. However, abnormal methylation, even of promote
Autor:
Karin B. Michels, Alexandra M. Binder, Benedetta Mussolin, Andrea Cassingena, Alice Vanzati, Mauro Truini, Salvatore Siena, Manel Esteller, Alessio Amatu, William M. Grady, Andrea Sartore-Bianchi, Simonetta Guarrera, Giulia Siravegna, Sebastian Moran, Sara Bustreo, Federica Di Nicolantonio, Alberto Bardelli, Patrizia Racca, Carlotta Cancelliere, Patrizia Zavattari, Daniele Oddo, Agostino Ponzetti, Giuseppe Matullo, Katia Bencardino, Carmen Cristiano, Sean K. Maden, Chiara Falcomatà, Ludovic Barault
Publikováno v:
Gut
ObjectiveMutations in cell-free circulating DNA (cfDNA) have been studied for tracking disease relapse in colorectal cancer (CRC). This approach requires personalised assay design due to the lack of universally mutated genes. In contrast, early methy
Publikováno v:
Epigenetics. 12:875-885
We investigated the impact of maternal smoking during pregnancy on placental DNA methylation and how this may mediate the association between maternal smoking and pro-inflammatory proteins in cord blood. The study population consisted of 27 individua
Autor:
Melanie Boerries, Hermann Brenner, Dominique Scherer, Stephanie Skender, Petra Schrotz-King, Alexis Ulrich, Peter Schirmacher, Martin F. Schneider, Lin Zielske, Nina Habermann, Timothy M. Barrow, Clare Abbenhardt-Martin, Hagen Klett, Jürgen Böhm, Cornelia M. Ulrich, Biljana Gigic, Karin B. Michels, Esther Herpel, Reka Toth, Hauke Busch
Publikováno v:
The Journal of Pathology. 243:366-375
Smoking tobacco is a known risk factor for the development of colorectal cancer, and for mortality associated with the disease. Smoking has been reported to be associated with changes in DNA methylation in blood and in lung tumour tissues, although t
Autor:
Karin B. Michels
Now in its second edition, this book provides a state of the art overview on basic concepts of epigenetic epidemiology and a comprehensive review of the rapidly evolving field of human epigenetics.Epigenetics plays an important role in shaping who we
Publikováno v:
The FASEB Journal. 31:5149-5158
Folic acid is an essential component of 1-carbon metabolism, which generates methyl groups for DNA methylation. Disruption of genomic imprinting leads to biallelic expression which may affect disease susceptibility possibly reflected in high levels o
Autor:
JoAnn E. Manson, Karin B. Michels, Lisa M. Troy, Elizabeth R. Bertone-Johnson, Maegan E Boutot, Alexandra C Purdue-Smithe, Susan E. Hankinson, Bernard Rosner, Kathleen Szegda, Brian W. Whitcomb
Publikováno v:
The American Journal of Clinical Nutrition. 105:1493-1501
Background: Early menopause, defined as the cessation of ovarian function before the age of 45 y, affects ∼10% of women and is associated with higher risk of cardiovascular disease, osteoporosis, and other conditions. Few modifiable risk factors fo
Autor:
Ricardo Uauy, Karin B. Michels, Daiana Quintiliano, John A. Shepherd, Ana Pereira, Camila Corvalán, Audrey J. Gaskins
Publikováno v:
The American Journal of Clinical Nutrition. 105:1166-1175
Background: Frequent dairy consumption in childhood has been related to higher growth-hormone concentrations that may affect mammary gland and pubertal development.Objective: We evaluated the relation of dairy intake to breast composition at Tanner s
Autor:
Xihong Lin, Joel Schwartz, Allan C. Just, Alexandra M. Binder, John N. Hutchinson, Sami S. Amr, Lorena Pantano, William P. Accomando, Karin B. Michels, Benedetta Izzi, Andrea A. Baccarelli, Pantel S. Vokonas, Juan Carmona
Publikováno v:
npj Genomic Medicine, Vol 2, Iss 1, Pp 1-10 (2017)
NPJ Genomic Medicine
NPJ genomic medicine, vol 2, iss 1
NPJ Genomic Medicine
NPJ genomic medicine, vol 2, iss 1
We empirically examined the strengths and weaknesses of two human genome-wide DNA methylation platforms: rapid multiplexed reduced representation bisulfite sequencing and Illumina’s Infinium BeadChip. Rapid multiplexed reduced representation bisulf