Zobrazeno 11 - 20
of 149
pro vyhledávání: '"Karel Souček"'
Autor:
Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Daniela Kurfűrstová, Radek Vrtěl, Vladimír Študent, Lucie Jurečková, Volodymyr Porokh, Aleš Hampl, Karel Souček
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 255-259 (2018)
A human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5™ Episomal iPSC Reprogramming Kit
Externí odkaz:
https://doaj.org/article/ff7f398ed78e4e059a1dbe047213f717
Publikováno v:
Non-Coding RNA, Vol 7, Iss 4, p 75 (2021)
Neuroendocrine prostate cancer (NEPC) represents a variant of prostate cancer that occurs in response to treatment resistance or, to a much lesser extent, de novo. Unravelling the molecular mechanisms behind transdifferentiation of cancer cells to ne
Externí odkaz:
https://doaj.org/article/830902918dfd48ce8cb40ed518dc1715
Autor:
Zuzana Kahounová, Ján Remšík, Radek Fedr, Jan Bouchal, Alena Mičková, Eva Slabáková, Lucia Binó, Aleš Hampl, Karel Souček
Publikováno v:
Stem Cell Research, Vol 46, Iss , Pp 101844- (2020)
Deciphering the properties of adult stem cells is crucial for understanding of their role in healthy tissue and in cancer progression as well. Both stem cells and cancer stem cells have shown association with epithelial-to-mesenchymal transition (EMT
Externí odkaz:
https://doaj.org/article/86a34fde54fb4d0281b36574a5423019
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that ep
Externí odkaz:
https://doaj.org/article/150e35241d6a4464be7e559790c1cedd
Autor:
Jarmila Herůdková, Kamil Paruch, Prashant Khirsariya, Karel Souček, Martin Krkoška, Olga Vondálová Blanářová, Petr Sova, Alois Kozubík, Alena Hyršlová Vaculová
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 830-841 (2017)
Although Chk1 kinase inhibitors are currently under clinical investigation as effective cancer cell sensitizers to the cytotoxic effects of numerous chemotherapeutics, there is still a considerable uncertainty regarding their role in modulation of an
Externí odkaz:
https://doaj.org/article/e81b0f5a2c1d4cceb65c2243075f3a24
Publikováno v:
Cancers, Vol 13, Iss 9, p 2188 (2021)
Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma known for its unusually aggressive behavior and poor clinical outcome. Besides the lack of molecular targets for therapy and profound intratumoral heterogeneity, the relatively qui
Externí odkaz:
https://doaj.org/article/669292bd25a54233b95bc92b5b53c6c8
Autor:
Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Radek Vrtěl, Lucie Jurečková, Volodymyr Porokh, Darja Páralová, Aleš Hampl, Karel Souček
Publikováno v:
Stem Cell Research, Vol 35, Iss , Pp - (2019)
Human induced pluripotent stem cell line was generated from commercially available primary human prostate fibroblasts HPrF derived from a fetus, aged 18–24 weeks of gestation. The fibroblast cell line was reprogrammed with Yamanaka factors (OCT4, S
Externí odkaz:
https://doaj.org/article/f112efb59bb94fadb1795db7605ea344
Publikováno v:
Cancers, Vol 12, Iss 11, p 3227 (2020)
Toll-like receptor 3 (TLR3) is a member of the TLR family, which has been extensively studied for its antiviral function. It is highly expressed in the endosomes of antigen-presenting immune cells and epithelial cells. TLR3 binds specifically double-
Externí odkaz:
https://doaj.org/article/c2c88bb503a64538b2db76d2e8e0aff7
Autor:
Tereza Kauerová, Tomáš Goněc, Josef Jampílek, Susanne Hafner, Ann-Kathrin Gaiser, Tatiana Syrovets, Radek Fedr, Karel Souček, Peter Kollar
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3416 (2020)
Ring-substituted 1-hydroxynaphthalene-2-carboxanilides were previously investigated for their antimycobacterial properties. In our study, we have shown their antiproliferative and cell death-inducing effects in cancer cell lines. Cell proliferation a
Externí odkaz:
https://doaj.org/article/7fd99a0c57d94701934f9d8f3cde11b7
Autor:
Hana Paculová, Juraj Kramara, Šárka Šimečková, Radek Fedr, Karel Souček, Ondřej Hylse, Kamil Paruch, Marek Svoboda, Martin Mistrík, Jiří Kohoutek
Publikováno v:
Tumor Biology, Vol 39 (2017)
A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the synthetic lethality between poly(ADP-ribose) polymerase 1/2 proteins and DNA damage response gen
Externí odkaz:
https://doaj.org/article/e7bcbdc4ad754e1e8d403ed31b65297e