Zobrazeno 11 - 20
of 223
pro vyhledávání: '"Juliann Chmielecki"'
Autor:
Gerald S Falchook, Jasgit Sachdev, Esteban Rodrigo Imedio, Sanjeev Kumar, Ganesh M Mugundu, Suzanne Jenkins, Juliann Chmielecki, Suzanne Jones, David R Spigel, Melissa Johnson
Publikováno v:
Investigational New Drugs.
Adavosertib selectively inhibits Wee1, which regulates intra-S and G2/M cell-cycle checkpoints. This study investigated dosing schedules for adavosertib monotherapy, determining the maximum tolerated dose (MTD) and recommended Phase II dose (RP2D) in
Autor:
Javed Khan, Douglas S. Hawkins, Matthew Meyerson, Frederic G. Barr, Stephen X. Skapek, James R. Anderson, Jaume Mora, Gad Getz, Thomas Badgett, Daniel Catchpoole, Sivasish Sindiri, Andrew S. Brohl, Dominik Bogen, Shile Zhang, Hongling Liao, Laura Hurd, Catherine Tolman, Young K. Song, Jianjun Wang, Daniel Auclair, Lauren Ambrogio, Mara Rosenberg, Rajesh Patidar, Jun S. Wei, Juliann Chmielecki, Li Chen, Jack F. Shern
PDF file 186K, Loss of heterozygosity on Chromosome 11p15.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45d983aade66abdb5c303e26744e4e3
https://doi.org/10.1158/2159-8290.22530849.v1
https://doi.org/10.1158/2159-8290.22530849.v1
Autor:
Philip J. Stephens, David S. Klimstra, Vincent A. Miller, William Pao, Roman Yelensky, Doron Lipson, Sohail Balasubramanian, Olca Basturk, Jeffrey S. Ross, Siraj M. Ali, Julia Elvin, Chanjuan Shi, Adrienne Johnson, Zachary R. Chalmers, Garrett M. Frampton, Katherine E. Hutchinson, Juliann Chmielecki
Supplementary Table S3: Genomic alterations across selected targets. See Figure 3 for additional details. Zoomable PDF.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730dc91166d6461a5ebeffa3ca2de1bf
https://doi.org/10.1158/2159-8290.22530626
https://doi.org/10.1158/2159-8290.22530626
Autor:
Javed Khan, Douglas S. Hawkins, Matthew Meyerson, Frederic G. Barr, Stephen X. Skapek, James R. Anderson, Jaume Mora, Gad Getz, Thomas Badgett, Daniel Catchpoole, Sivasish Sindiri, Andrew S. Brohl, Dominik Bogen, Shile Zhang, Hongling Liao, Laura Hurd, Catherine Tolman, Young K. Song, Jianjun Wang, Daniel Auclair, Lauren Ambrogio, Mara Rosenberg, Rajesh Patidar, Jun S. Wei, Juliann Chmielecki, Li Chen, Jack F. Shern
PDF file 92K, Supplementary Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a80ec84c5c621df249ba20296279c17
https://doi.org/10.1158/2159-8290.22530840.v1
https://doi.org/10.1158/2159-8290.22530840.v1
Autor:
Philip J. Stephens, David S. Klimstra, Vincent A. Miller, William Pao, Roman Yelensky, Doron Lipson, Sohail Balasubramanian, Olca Basturk, Jeffrey S. Ross, Siraj M. Ali, Julia Elvin, Chanjuan Shi, Adrienne Johnson, Zachary R. Chalmers, Garrett M. Frampton, Katherine E. Hutchinson, Juliann Chmielecki
Supplementary Fig. S3: Co-mutation across all PACC tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1d15f4db69ee89c3f1d2d226dfe6be
https://doi.org/10.1158/2159-8290.22530638
https://doi.org/10.1158/2159-8290.22530638
Autor:
Philip J. Stephens, David S. Klimstra, Vincent A. Miller, William Pao, Roman Yelensky, Doron Lipson, Sohail Balasubramanian, Olca Basturk, Jeffrey S. Ross, Siraj M. Ali, Julia Elvin, Chanjuan Shi, Adrienne Johnson, Zachary R. Chalmers, Garrett M. Frampton, Katherine E. Hutchinson, Juliann Chmielecki
Additional detailed methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5318fc925ef9365ca571b002fc36664e
https://doi.org/10.1158/2159-8290.22530635
https://doi.org/10.1158/2159-8290.22530635
Autor:
Vincent A. Miller, Philip J. Stephens, Malte Peters, Eric Collisson, Jeffrey S. Ross, Deborah Morosini, Roman Yelensky, Doron Lipson, Robert Schlegel, Joel Greshock, Jared White, Steven Roels, Eric M. Sanford, Caitlin McMahon, Depinder Khaira, Adrienne Johnson, Joel Greenbowe, Kyle A. Gowen, Alex Fichtenholtz, Rachel Erlich, Julia A. Elvin, Alan Huang, Savina Jaeger, Zachary R. Chalmers, Tim Brennan, Ravi Salgia, Sai-Hong Ignatius Ou, Rick Hoover, David Jentz, Carrie Lee, Jose A. Bufill, Mikhail Akimov, Todd M. Bauer, Xinyuan Lu, Juliann Chmielecki, Mark Rosenzweig, Siraj M. Ali, Garrett M. Frampton
Genomic alterations in lung adenocarcinoma displayed in Figure 2A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bef9595be8a039a3d2c2847080d6e54
https://doi.org/10.1158/2159-8290.22530219.v1
https://doi.org/10.1158/2159-8290.22530219.v1
Autor:
Vincent A. Miller, Philip J. Stephens, Malte Peters, Eric Collisson, Jeffrey S. Ross, Deborah Morosini, Roman Yelensky, Doron Lipson, Robert Schlegel, Joel Greshock, Jared White, Steven Roels, Eric M. Sanford, Caitlin McMahon, Depinder Khaira, Adrienne Johnson, Joel Greenbowe, Kyle A. Gowen, Alex Fichtenholtz, Rachel Erlich, Julia A. Elvin, Alan Huang, Savina Jaeger, Zachary R. Chalmers, Tim Brennan, Ravi Salgia, Sai-Hong Ignatius Ou, Rick Hoover, David Jentz, Carrie Lee, Jose A. Bufill, Mikhail Akimov, Todd M. Bauer, Xinyuan Lu, Juliann Chmielecki, Mark Rosenzweig, Siraj M. Ali, Garrett M. Frampton
Focal amplification and activating point mutation of the MET gene are well-characterized oncogenic drivers that confer susceptibility to targeted MET inhibitors. Recurrent somatic splice site alterations at MET exon 14 (METex14) that result in exon s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e45f91fabb778931c2686fc61c7ae60
https://doi.org/10.1158/2159-8290.c.6546132.v1
https://doi.org/10.1158/2159-8290.c.6546132.v1
Autor:
Javed Khan, Douglas S. Hawkins, Matthew Meyerson, Frederic G. Barr, Stephen X. Skapek, James R. Anderson, Jaume Mora, Gad Getz, Thomas Badgett, Daniel Catchpoole, Sivasish Sindiri, Andrew S. Brohl, Dominik Bogen, Shile Zhang, Hongling Liao, Laura Hurd, Catherine Tolman, Young K. Song, Jianjun Wang, Daniel Auclair, Lauren Ambrogio, Mara Rosenberg, Rajesh Patidar, Jun S. Wei, Juliann Chmielecki, Li Chen, Jack F. Shern
XLSX file 2844K, Supplementary Tables S1-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6d4d81e83d0c2af6a90f104e205a2e
https://doi.org/10.1158/2159-8290.22530837
https://doi.org/10.1158/2159-8290.22530837
Autor:
Philip J. Stephens, David S. Klimstra, Vincent A. Miller, William Pao, Roman Yelensky, Doron Lipson, Sohail Balasubramanian, Olca Basturk, Jeffrey S. Ross, Siraj M. Ali, Julia Elvin, Chanjuan Shi, Adrienne Johnson, Zachary R. Chalmers, Garrett M. Frampton, Katherine E. Hutchinson, Juliann Chmielecki
Supplementary Table S1A: Genes analyzed for base substitutions, short insertions/deletions, and copy number alterations (DNA). Supplementary Table S1B: Genes analyzed for rearrangements (DNA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255d0ded0d67e25cf83bf764d7a5fb37
https://doi.org/10.1158/2159-8290.22530632
https://doi.org/10.1158/2159-8290.22530632