Zobrazeno 31 - 34
of 34
pro vyhledávání: '"Julia Jellusova"'
Autor:
Erika Lattová, Vic Spicer, Julia Jellusova, Dorota Bartusik, Hélène Perreault, Boguslaw Tomanek
Publikováno v:
Molecularcellular proteomics : MCP. 10(9)
The therapeutic humanized monoclonal antibody IgG1 known as Herceptin® has shown remarkable antitumor effects. Although this type of therapy has increased the cancer-free survival of patients, not all tumors respond to this treatment and cancers oft
Autor:
Julia Jellusova, Reinhard E. Voll, Siegfried Weiss, Christoph J. Binder, Eva Gückel, Sandra Düber, Lars Nitschke
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 185(6)
Siglec-G is a negative regulator of BCR-mediated signaling in B1a cells. This population of B cells is highly increased in Siglec-G–deficient mice, but the mechanism of this expansion is not known so far. In this study, we demonstrate that Siglecg
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 184(7)
CD22 and Siglec-G are inhibitory coreceptors for BCR-mediated signaling. Although CD22-deficient mice show increased calcium signaling in their conventional B2 cells and a quite normal B cell maturation, Siglec-G–deficient mice have increased calci
Autor:
Sheena C. Kerr, Jiquan Zhang, Anja Hoffmann, Florian Weisel, Paul R. Crocker, Lars Nitschke, Thomas Winkler, Julia Jellusova, Burkhard Kneitz, Ute Wellmann
Publikováno v:
Nature immunology. 8(7)
B1 cells are an important cell population for the production of natural antibodies and for antibacterial immunoglobulin responses. Here we identified the mouse protein Siglec-G as a B1 cell inhibitory receptor. Siglec-G was expressed in a B cell–re
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