Zobrazeno 51 - 60
of 88
pro vyhledávání: '"Judy Dering"'
Autor:
Judy Dering, Lee Anderson, Dennis J. Slamon, C Ginther, Beth Y. Karlan, Marlena S. Fejzo, Gottfried E. Konecny, Natarajan Venkatesan
Publikováno v:
Genes, Chromosomes and Cancer. 50:434-441
Approximately 25,000 ovarian cancers are diagnosed in the United States annually, and 75% of cases are in the advanced stage when they are largely incurable. There is a critical need for improved early detection tools and development of novel treatme
Autor:
Min Zhu, Judy Dering, Dennis J. Slamon, Lillian Ramos, Marlena S. Fejzo, Lee Anderson, Judith C. Gasson, Beth Y. Karlan, Charles Ginther
Publikováno v:
Gynecologic Oncology. 119:337-344
Objective Perostin (PN) has been found to be overexpressed in a variety of human malignancies including ovarian cancer. In the present study, we investigated PN expression status in a large cohort of ovarian tumors with the focus on biological influe
Autor:
Helen Brown, Feng Xing, Rose McCormack, Nicholas K. Hayward, Christine M. Chresta, Tim French, Leisl M. Packer, Vanessa F. Bonazzi, David B. Solit, Gillian Ellison, Andrew Cassidy, Garry Beran, Sugandha Ravishankar, Sandra Pavey, Chris Harbron, Richard S. Finn, Darren Hodgson, Christine A. Pratilas, Neal Rosen, Paul D. Smith, Sarah Runswick, Mitchell S. Stark, Barry S. Taylor, Alexander Graham, Natalie Byrne, Judy Dering, Mark Cockerill, Jonathan R. Dry, Carolyn Haggerty
Publikováno v:
Cancer Research. 70:2264-2273
Selumetinib (AZD6244, ARRY-142886) is a selective, non–ATP-competitive inhibitor of mitogen-activated protein/extracellular signal–regulated kinase kinase (MEK)-1/2. The range of antitumor activity seen preclinically and in patients highlights th
Autor:
Marlena S. Fejzo, Judy Dering, Beth Y. Karlan, Lilian Ramos, Christine Walsh, C Ginther, Lee Anderson, Dennis J. Slamon
Publikováno v:
Genes, Chromosomes and Cancer. 47:873-883
Approximately 25,000 ovarian cancers are diagnosed in the US annually, and 75% of cases are in the advanced stage when they are largely incurable. There is a critical need for improved early detection tools and development of novel treatments. Becaus
Autor:
Masashi Sanada, Hisae Karahashi, Charles Ginther, Christine Walsh, Hang Tran, Norihiko Kawamata, Seishi Ogawa, Dennis J. Slamon, James C. Pavelka, Yasuhito Nannya, Carl W. Miller, H. Phillip Koeffler, Beth Y. Karlan, Judy Dering, Daniel R. Scoles
Publikováno v:
Journal of Clinical Oncology. 26:2952-2958
Purpose To identify a biomarker of ovarian cancer response to chemotherapy. Patients and Methods Study participants had epithelial ovarian cancer treated with surgery followed by platinum-based chemotherapy. DNA and RNA were isolated from frozen tumo
Autor:
Ellen L. Goode, Lynn C. Hartmann, Boris Winterhoff, Chen Wang, Judy Dering, Hsiao Wang Chen, Bobbie S. Gostout, Gottfried E. Konecny, Charles Ginther, Sean C. Dowdy, Dennis J. Slamon, He-Jing Wang, William A. Cliby, Karl C. Podratz, Gary L. Keeney, Kimberly R. Kalli, Habib Hamidi
Publikováno v:
Journal of the National Cancer Institute, vol 106, iss 10
Konecny, GE; Wang, C; Hamidi, H; Winterhoff, B; Kalli, KR; Dering, J; et al.(2014). Prognostic and therapeutic relevance of molecular subtypes in high-grade serous ovarian cancer.. Journal of the National Cancer Institute, 106(10). UCLA: Retrieved from: http://www.escholarship.org/uc/item/5832f1n7
Konecny, GE; Wang, C; Hamidi, H; Winterhoff, B; Kalli, KR; Dering, J; et al.(2014). Prognostic and therapeutic relevance of molecular subtypes in high-grade serous ovarian cancer.. Journal of the National Cancer Institute, 106(10). UCLA: Retrieved from: http://www.escholarship.org/uc/item/5832f1n7
Molecular classification of high-grade serous ovarian cancer (HGSOC) using transcriptional profiling has proven to be complex and difficult to validate across studies. We determined gene expression profiles of 174 well-annotated HGSOCs and demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd090dcc47f91e38d7d8d5828a7bd445
https://escholarship.org/uc/item/5832f1n7
https://escholarship.org/uc/item/5832f1n7
Autor:
Dennis J. Slamon, Naeimeh Kamranpour, Aaron Lisberg, Maria Velez, Dongmei Hou, Robert B. Cameron, Judy Dering, Steven M. Dubinett, Jay Lee, Robert J. McKenna, Hsiao-Wang Chen
Publikováno v:
Journal of Thoracic Oncology. 12:S835
Autor:
Alison M. Karst, Michael G. Drage, Rachel A. Davidowitz, Ronny Drapkin, Gottfried E. Konecny, Judy Dering, Huiying Piao, Dennis J. Slamon, Kevin M. Elias, Laura M. Selfors, Gordon B. Mills, Joan S. Brugge, Ursula A. Matulonis, Marcin P. Iwanicki, Tan A. Ince
Publikováno v:
The Journal of clinical investigation. 124(6)
Metastatic dissemination of ovarian tumors involves the invasion of tumor cell clusters into the mesothelial cell lining of peritoneal cavity organs; however, the tumor-specific factors that allow ovarian cancer cells to spread are unclear. We used a
Autor:
Dong-Joo Cheon, Dror Berel, Jenny Lester, Mourad Tighiouart, Beth Y. Karlan, Sandra Orsulic, Ann E. Walts, Yunguang Tong, Jessica A. Beach, Judy Dering, Myung-Shin Sim, Xiaojiang Cui
Publikováno v:
Cheon, DJ; Tong, Y; Sim, MS; Dering, J; Berel, D; Cui, X; et al.(2014). A collagen-remodeling gene signature regulated by TGF-β signaling is associated with metastasis and poor survival in serous ovarian cancer. Clinical Cancer Research, 20(3), 711-723. doi: 10.1158/1078-0432.CCR-13-1256. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7494c1dn
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 20, iss 3
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 20, iss 3
Purpose: To elucidate molecular pathways contributing to metastatic cancer progression and poor clinical outcome in serous ovarian cancer. Experimental Design: Poor survival signatures from three different serous ovarian cancer datasets were compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ed516c9b354fd37df4cfa72fe3d142
http://www.escholarship.org/uc/item/7494c1dn
http://www.escholarship.org/uc/item/7494c1dn
POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer
Autor:
Dennis J. Slamon, Beth Y. Karlan, Charles Ginther, Christine Walsh, Sandra Orsulic, Marlena S. Fejzo, Jenny Lester, Judy Dering, Lee Anderson
Publikováno v:
Karlan, BY; Dering, J; Walsh, C; Orsulic, S; Lester, J; Anderson, LA; et al.(2014). POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer. Gynecologic Oncology, 132(2), 334-342. doi: 10.1016/j.ygyno.2013.12.021. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0mq7k8bp
Gynecologic oncology, vol 132, iss 2
Gynecologic oncology, vol 132, iss 2
Objective To identify molecular prognosticators and therapeutic targets for high-grade serous epithelial ovarian cancers (EOCs) using genetic analyses driven by biologic features of EOC pathogenesis. Methods Ovarian tissue samples (n = 172; 122 serou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0a33246353d6c8fa3df5d40e4fa13f
http://www.escholarship.org/uc/item/0mq7k8bp
http://www.escholarship.org/uc/item/0mq7k8bp