Zobrazeno 41 - 50
of 382
pro vyhledávání: '"Jonathan E. Kolitz"'
Autor:
Jessica Kohlschmidt, Richard Stone, Dimitrios Papaioannou, Clara D. Bloomfield, Adrienne M. Dorrance, Marius Bill, Bayard L. Powell, Andrew J. Carroll, Deedra Nicolet, Jonathan E. Kolitz, Ramiro Garzon, John C. Byrd, Ann-Kathrin Eisfeld, Zachary Brannan, Xiaoqing Rong-Mullins, Krzysztof Mrózek, Kellie J. Archer, Christopher J. Walker
Publikováno v:
Haematologica
Leukemia stem cells (LSC) are more resistant to standard chemotherapy and their persistence during remission can cause relapse, which is still one of the major clinical challenges in the treatment of acute myeloid leukemia (AML). A better understandi
Autor:
Sophia E. Maharry, Clara D. Bloomfield, Marius Bill, Sandya Liyanarachchi, Christopher C. Oakes, Chi Song, Christopher J. Walker, Albert de la Chapelle, Geoffrey L. Uy, Brian Giacopelli, James S. Blachly, Bayard L. Powell, Eunice S. Wang, Shelley Orwick, Jonathan E. Kolitz, Richard Stone, Deedra Nicolet, Kellie J. Archer, Ann-Kathrin Eisfeld, John C. Byrd, Luke K Genutis, Jessica Kohlschmidt, Dimitrios Papaioannou, Krzysztof Mrózek, Andrew J. Carroll
Publikováno v:
Clin Cancer Res
Purpose:Uniparental disomy (UPD) is a way cancer cells duplicate a mutated gene, causing loss of heterozygosity (LOH). Patients with cytogenetically normal acute myeloid leukemia (CN-AML) do not have microscopically detectable chromosome abnormalitie
Autor:
James S. Blachly, Andrew J. Carroll, John C. Byrd, Christopher C. Oakes, Sydney Fobare, Shelley Orwick, Richard Stone, Krzysztof Mrózek, Alice S. Mims, Eunice S. Wang, Hatice Gulcin Ozer, Bayard L. Powell, Ann-Kathrin Eisfeld, Jonathan E. Kolitz, Ramiro Garzon, Jessica Kohlschmidt, Deedra Nicolet, Erin Hertlein
Publikováno v:
Blood advances. 6(5)
Prognostic factors associated with chemotherapy outcomes in patients with acute myeloid leukemia (AML) are extensively reported, and one gene whose mutation is recognized as conferring resistance to several newer targeted therapies is protein tyrosin
Autor:
Christopher J. Walker, Richard Stone, Ann-Kathrin Eisfeld, Bayard L. Powell, Electra D. Paskett, Qiuhong Zhao, James L. Fisher, Alice S. Mims, Jonathan E. Kolitz, Jessica Kohlschmidt, Ramiro Garzon, John C. Byrd, James S. Blachly, Krzysztof Mrózek, Deedra Nicolet, Albert de la Chapelle, Shelley Orwick, Clara D. Bloomfield, Andrew J. Carroll, Bhavana Bhatnagar
Publikováno v:
Blood. 136:5-7
Background: AML is a clinically and molecularly heterogeneous disease associated with poor survival. Multiple disease-related factors including cytogenetic findings and gene mutations, as well as patient-related factors, such as demographics and Afri
Publikováno v:
Journal of Clinical Oncology. 40:e18594-e18594
e18594 Background: Disparities in cancer clinical trials limit the real-world reproducibility of their results while remaining inapplicable to excluded patients (pts) like those living with chronic viral infections. Non-Hodgkin lymphoma (NHL) has an
Autor:
Jonathan E. Kolitz, Susan M. Christner, Michaela Liedtke, Richard Stone, Geoffrey L. Uy, Meir Wetzler, Jan H. Beumer, Lionel D. Lewis, Jun Yin, Matthew J Wieduwilt, Wendy Stock, Elizabeth Storrick, Richard A. Larson, Steven M. Devine, Ryan J. Mattison, Bayard L. Powell
Publikováno v:
Blood Advances
Key Points Dasatinib and dexamethasone induction then allogeneic hematopoietic cell transplantation was feasible and effective for untreated Ph+ ALL.Treatment failure was associated with BCR-ABL1 T315I mutation, the p210 BCR-ABL1 isoform, or isolated
Autor:
Clara D. Bloomfield, Bayard L. Powell, Andrew J. Carroll, Shelley Orwick, Ann-Kathrin Eisfeld, Jessica Kohlschmidt, Bhavana Bhatnagar, Dimitrios Papaioannou, Richard Stone, Deedra Nicolet, Krzysztof Mrózek, John C. Byrd, Jonathan E. Kolitz, Christopher J. Walker, James S. Blachly
Publikováno v:
Leukemia. 34:358-368
Sole trisomies of chromosomes 4, 8, 11, 13 and 21 account for 89–95% of all sole trisomies in adult AML patients. We analyzed clinical and molecular characteristics of 138 de novo AML patients with sole +4, +8, +11, +13 or +21, and compared them wi
Autor:
Jessica Kohlschmidt, Dimitrios Papaioannou, Clara D. Bloomfield, Paolo Fadda, Deedra Nicolet, Richard Stone, Andrew J. Carroll, John C. Byrd, Eunice S. Wang, Hatice Gulcin Ozer, Stefano Volinia, Jonathan E. Kolitz, Ramiro Garzon, Krzysztof Mrózek
Publikováno v:
Molecular Cancer Therapeutics. 18:1451-1459
We have previously shown that expression levels of 48 long noncoding RNAs (lncRNA) can generate a prognostic lncRNA score that independently associates with outcome of older patients with cytogenetically normal acute myeloid leukemia (CN-AML). Howeve
Autor:
Kanti R. Rai, Jacqueline C. Barrientos, Steven L. Allen, Patricia K. A. Mongini, Nicholas Chiorazzi, Jonathan E. Kolitz, Wentian Li, Rashmi Gupta, Xiao J. Yan
Publikováno v:
The Journal of Immunology. 202:2924-2944
Clonal expansion of B cell chronic lymphocytic leukemia (B-CLL) occurs within lymphoid tissue pseudofollicles. IL-15, a stromal cell–associated cytokine found within spleens and lymph nodes of B-CLL patients, significantly boosts in vitro cycling o
Autor:
Jonathan E. Kolitz, William Blum, Christopher J. Walker, Ann-Kathrin Eisfeld, Jessica Kohlschmidt, James S. Blachly, Dimitrios Papaioannou, Deedra Nicolet, Geoffrey L. Uy, Eunice S. Wang, Marius Bill, Richard Stone, Krzysztof Mrózek, Bayard L. Powell, Clara D. Bloomfield, Andrew J. Carroll, John C. Byrd
Publikováno v:
Leukemia
Complex karyotype (CK) with ≥ 3 abnormalities is detected in 10–12% of patients with acute myeloid leukemia (AML) and associated with poor prognosis. The most common unbalanced abnormalities found in CK result in loss of material from the 5q, 7q,