Zobrazeno 21 - 30
of 192
pro vyhledávání: '"John M. Hickey"'
Publikováno v:
Genetics Selection Evolution, Vol 51, Iss 1, Pp 1-9 (2019)
Abstract Background In this paper, we evaluate the performance of using family-specific low-density genotype arrays to increase the accuracy of pedigree-based imputation. Genotype imputation is a widely used tool that decreases the costs of genotypin
Externí odkaz:
https://doaj.org/article/f98e80aeee3a4f929bfbe242bfebfbb7
Autor:
Martin Johnsson, R. Chris Gaynor, Janez Jenko, Gregor Gorjanc, Dirk-Jan de Koning, John M. Hickey
Publikováno v:
Genetics Selection Evolution, Vol 51, Iss 1, Pp 1-18 (2019)
Abstract Background In this paper, we simulate deleterious load in an animal breeding program, and compare the efficiency of genome editing and selection for decreasing it. Deleterious variants can be identified by bioinformatics screening methods th
Externí odkaz:
https://doaj.org/article/61720668d68645c2bf775e6de2b65478
Autor:
Janez Jenko, Matthew C. McClure, Daragh Matthews, Jennifer McClure, Martin Johnsson, Gregor Gorjanc, John M. Hickey
Publikováno v:
Genetics Selection Evolution, Vol 51, Iss 1, Pp 1-14 (2019)
Abstract Background In livestock, deleterious recessive alleles can result in reduced economic performance of homozygous individuals in multiple ways, e.g. early embryonic death, death soon after birth, or semi-lethality with incomplete penetrance ca
Externí odkaz:
https://doaj.org/article/77f9be1986ff460c86aec30900f1fc46
Autor:
Paolo Gottardo, Gregor Gorjanc, Mara Battagin, R. Chris Gaynor, Janez Jenko, Roger Ros-Freixedes, C. Bruce A. Whitelaw, Alan J. Mileham, William O. Herring, John M. Hickey
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 1, Pp 203-215 (2019)
In this work, we performed simulations to develop and test a strategy for exploiting surrogate sire technology in animal breeding programs. Surrogate sire technology allows the creation of males that lack their own germline cells, but have transplant
Externí odkaz:
https://doaj.org/article/ee8c57aefe4e45d785ef036b431fd1f6
Autor:
Roger Ros-Freixedes, Mara Battagin, Martin Johnsson, Gregor Gorjanc, Alan J. Mileham, Steve D. Rounsley, John M. Hickey
Publikováno v:
Genetics Selection Evolution, Vol 50, Iss 1, Pp 1-14 (2018)
Abstract Background Inherent sources of error and bias that affect the quality of sequence data include index hopping and bias towards the reference allele. The impact of these artefacts is likely greater for low-coverage data than for high-coverage
Externí odkaz:
https://doaj.org/article/6001d496d048428ca68f5d859bd1cbea
Autor:
Martin Johnsson, Roger Ros-Freixedes, Gregor Gorjanc, Matt A. Campbell, Sudhir Naswa, Kimberly Kelly, Jonathan Lightner, Steve Rounsley, John M. Hickey
Publikováno v:
Genetics Selection Evolution, Vol 50, Iss 1, Pp 1-9 (2018)
Abstract Background In this work, we investigated sequence variation, evolutionary constraint, and selection at the CD163 gene in pigs. A functional CD163 protein is required for infection by porcine reproductive and respiratory syndrome virus, which
Externí odkaz:
https://doaj.org/article/1342d32d42c845b1a4daa51b7c3dd379
Publikováno v:
Genetics Selection Evolution, Vol 50, Iss 1, Pp 1-15 (2018)
Abstract Background In this paper, we extend multi-locus iterative peeling to provide a computationally efficient method for calling, phasing, and imputing sequence data of any coverage in small or large pedigrees. Our method, called hybrid peeling,
Externí odkaz:
https://doaj.org/article/74f19d25aa0c44ca9b65ac0249fc1cd9
Publikováno v:
Genetics Selection Evolution, Vol 50, Iss 1, Pp 1-10 (2018)
Abstract Background In this paper, we review the performance of various hidden Markov model-based imputation methods in animal breeding populations. Traditionally, pedigree and heuristic-based imputation methods have been used for imputation in large
Externí odkaz:
https://doaj.org/article/9e91a2429742401da63d1e5f95fde8e2
Autor:
Jon Bančič, Christian R. Werner, R. Chris Gaynor, Gregor Gorjanc, Damaris A. Odeny, Henry F. Ojulong, Ian K. Dawson, Stephen P. Hoad, John M. Hickey
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Intercrop breeding programs using genomic selection can produce faster genetic gain than intercrop breeding programs using phenotypic selection. Intercropping is an agricultural practice in which two or more component crops are grown together. It can
Externí odkaz:
https://doaj.org/article/9feb5f58bcc5407eaf894e52d869ceb2
Autor:
Christian R. Werner, R. Chris Gaynor, Gregor Gorjanc, John M. Hickey, Tobias Kox, Amine Abbadi, Gunhild Leckband, Rod J. Snowdon, Andreas Stahl
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Over the last two decades, the application of genomic selection has been extensively studied in various crop species, and it has become a common practice to report prediction accuracies using cross validation. However, genomic prediction accuracies o
Externí odkaz:
https://doaj.org/article/68e6be21435f4fb8a2eb6f3c301efc3e