Zobrazeno 51 - 60
of 259
pro vyhledávání: '"Jian-Jian Li"'
Autor:
Hongwu Chen, Ryan Wei, Ming Fan, Lin Liu, Yiyang Hu, Joy X. Jiang, Demet Candas-Green, Bowen Xie, Jian Jian Li, Yinsheng Wang
Publikováno v:
Developmental cell, vol 52, iss 2
Dev Cell
Dev Cell
Saturated fatty acids (SFAs) (the "bad" fat), especially palmitate (PA), in the human diet are blamed for potential health risks such as obesity and cancer because of SFA-induced lipotoxicity. However, epidemiological results demonstrate a latent ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dbd224bdbe70b333ee67d38df6552b
https://escholarship.org/uc/item/9k37t12f
https://escholarship.org/uc/item/9k37t12f
Autor:
Shujun Han, Ryan Wei, Xiaodi Zhang, Nian Jiang, Ming Fan, Jie Hunter Huang, Bowen Xie, Lu Zhang, Weili Miao, Ashley Chen-Ping Butler, Matthew A. Coleman, Andrew T. Vaughan, Yinsheng Wang, Hong-Wu Chen, Jiankang Liu, Jian Jian Li
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology
Frontiers in Oncology
Tumor cells, including cancer stem cells (CSCs) resistant to radio- and chemotherapy, must enhance metabolism to meet the extra energy demands to repair and survive such genotoxic conditions. However, such stress-induced adaptive metabolic alteration
Publikováno v:
Cancer Research. 79:P4-06
Background. Toll-like receptors (TLR) recognize conserved molecular patterns expressed by microbes and together with other molecular sensors serve as a first line of defense, inducing soluble and cellular mediators of innate immunity and initiating k
Autor:
Peng Yuan, X Jin, Xu Guo, Li Zs, Xiacheng Sun, Xiaojun Huang, Tingting Ren, Hongxin Zhang, Jian Jian Li, X Long, Jun-Ling Xing, Qichao Huang
Publikováno v:
Oncogene. 36:4901-4912
To date, mechanisms of tumour cell survival under energy stress are not well understood. Cumulative evidence is beginning to reveal that specific mitochondrial morphologies are often associated with energetic states and survival of cells. However, th
Autor:
Ruben C Fragoso, Nian Jiang, Jian Jian Li, Bowen Xie, Lun-Quan Sun, Ming Fan, Lu Zhang, Wenwu Xiao, Di Jing, Kit S. Lam, Wenfeng Hu, Yumei Duan
Publikováno v:
Redox Biology, Vol 24, Iss, Pp-(2019)
Radiotherapy (RT) is the major modality for control of glioblastoma multiforme (GBM), the most aggressive brain tumor in adults with poor prognosis and low patient survival rate. To improve the RT efficacy on GBM, the mechanism causing tumor adaptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf5509a36ea6c2619b864039414a807
https://escholarship.org/uc/item/8kv673wt
https://escholarship.org/uc/item/8kv673wt
Autor:
Ming Fan, Jian Jian Li, Junjian Wang, Zhijian Duan, Jing Shen, Nicolas P. Andrews, Hongwu Chen, Christopher Z. Chen
Publikováno v:
Oncology reports. 43(1)
Bromodomain proteins such as BRD4 chromatin regulator are attractive cancer therapeutic targets. ANCCA (AAA+ nuclear coregulatory cancer‑associated protein, also known as ATPase family AAA domain containing 2 or ATAD2) is a novel oncology drug targ
Publikováno v:
Chemical research in toxicology, vol 32, iss 2
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women. Radioresistance remains one of the most critical barriers in radiation therapy for breast cancer. In this study, we employed a parallel-reactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98df5eaa2290f61b3a49d716bc34e5b3
https://escholarship.org/uc/item/4c5298xh
https://escholarship.org/uc/item/4c5298xh
Autor:
Hsing Jien Kung, Junjian Wang, Zenghong Huang, Feng Wu, Ka Fai To, Alexander D. Borowsky, Oliver Fiehn, Xinbin Chen, Primo N. Lara, Demin Cai, Kit S. Lam, June X. Zou, Richard J. Bold, Ruqian Zhao, Bei Gao, Jin Li, Jian Jian Li, Hongwu Chen, Ronald M. Evans, Hongye Zou, Jianzhen Xu, Yuqian Jiang
Publikováno v:
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear r
Publikováno v:
Theranostics
Theranostics, vol 9, iss 5
Theranostics, vol 9, iss 5
Radiotherapy (RT), the major anti-cancer modality for more than half of cancer patients after diagnosis, has the advantage of local tumor control with relatively less systematic side effects comparing to chemotherapy. However, the efficacy of RT is l
A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and regener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1fd3e898f8dffaffcbbfa4dca418a2
https://europepmc.org/articles/PMC6759061/
https://europepmc.org/articles/PMC6759061/