Zobrazeno 11 - 20
of 646
pro vyhledávání: '"Jeremy N. Rich"'
Autor:
Li Jiang, Yajing Hao, Changwei Shao, Qiulian Wu, Briana C. Prager, Ryan C. Gimple, Gabriele Sulli, Leo J.Y. Kim, Guoxin Zhang, Zhixin Qiu, Zhe Zhu, Xiang-Dong Fu, Jeremy N. Rich
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor, containing GBM stem cells (GSCs) that contribute to therapeutic resistance and relapse. Exposing potential GSC vulnerabilities may provide therapeutic strategies against
Externí odkaz:
https://doaj.org/article/9e343997925d42dba86e8ff866779674
Autor:
Junfeng Bi, Atif Khan, Jun Tang, Aaron M. Armando, Sihan Wu, Wei Zhang, Ryan C. Gimple, Alex Reed, Hui Jing, Tomoyuki Koga, Ivy Tsz-Lo Wong, Yuchao Gu, Shunichiro Miki, Huijun Yang, Briana Prager, Ellis J. Curtis, Derek A. Wainwright, Frank B. Furnari, Jeremy N. Rich, Timothy F. Cloughesy, Harley I. Kornblum, Oswald Quehenberger, Andrey Rzhetsky, Benjamin F. Cravatt, Paul S. Mischel
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109957- (2021)
Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify sphingomyelin phosphodies
Externí odkaz:
https://doaj.org/article/8516b7196aa84c49af33aefb9f94a103
Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
Autor:
Weiwei Tao, Chengwei Chu, Wenchao Zhou, Zhi Huang, Kui Zhai, Xiaoguang Fang, Qian Huang, Aili Zhang, Xiuxing Wang, Xingjiang Yu, Haidong Huang, Qiulian Wu, Andrew E. Sloan, Jennifer S. Yu, Xiaoxia Li, George R. Stark, Jeremy N. Rich, Shideng Bao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The tumour microenvironment plays an important role in promoting glioblastoma. Here, the authors show that glioma stem cells secrete WISP1, which promotes both the survival of the stem cells and tumour-associated macrophages.
Externí odkaz:
https://doaj.org/article/80ed06b6daa44b72a61177b8c8e47066
Autor:
Sharmila Nair, Luciano Mazzoccoli, Arijita Jash, Jennifer Govero, Sachendra S. Bais, Tong Hu, Camila R. Fontes-Garfias, Chao Shan, Hideho Okada, Sujan Shresta, Jeremy N. Rich, Pei-Yong Shi, Michael S. Diamond, Milan G. Chheda
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are resistant to therapy and recurrence is inevitable. Previously, we demonstrated Zika virus (ZIKV) targets GBM stem cells and prevents death of mice with gliomas.
Externí odkaz:
https://doaj.org/article/cc0774b684754a278d9b7e4db97ef179
Autor:
Xun Jin, Hye-Min Jeon, Xiong Jin, Eun-Jung Kim, Jinlong Yin, Hee-Young Jeon, Young-Woo Sohn, Se-Yeong Oh, Jun-Kyum Kim, Sung-Hak Kim, Ji-Eun Jung, Sungwook Kwak, Kai-Fu Tang, Yunsheng Xu, Jeremy N. Rich, Hyunggee Kim
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1629-1641 (2016)
Inhibitor of differentiation 1 (ID1) is highly expressed in glioblastoma stem cells (GSCs). However, the regulatory mechanism responsible for its role in GSCs is poorly understood. Here, we report that ID1 activates GSC proliferation, self-renewal, a
Externí odkaz:
https://doaj.org/article/6e6373a1f43d4a54ab2df7a1746c7577
Autor:
Masahiro Hitomi, Loic P. Deleyrolle, Erin E. Mulkearns-Hubert, Awad Jarrar, Meizhang Li, Maksim Sinyuk, Balint Otvos, Sylvain Brunet, William A. Flavahan, Christopher G. Hubert, Winston Goan, James S. Hale, Alvaro G. Alvarado, Ao Zhang, Mark Rohaus, Muna Oli, Vinata Vedam-Mai, Jeff M. Fortin, Hunter S. Futch, Benjamin Griffith, Qiulian Wu, Chun-hong Xia, Xiaohua Gong, Manmeet S. Ahluwalia, Jeremy N. Rich, Brent A. Reynolds, Justin D. Lathia
Publikováno v:
Cell Reports, Vol 11, Iss 7, Pp 1031-1042 (2015)
The coordination of complex tumor processes requires cells to rapidly modify their phenotype and is achieved by direct cell-cell communication through gap junction channels composed of connexins. Previous reports have suggested that gap junctions are
Externí odkaz:
https://doaj.org/article/494a4a229a984f468e7f3e93cceb546e
Autor:
Jianghong Man, Jocelyn Shoemake, Wenchao Zhou, Xiaoguang Fang, Qiulian Wu, Anthony Rizzo, Richard Prayson, Shideng Bao, Jeremy N. Rich, Jennifer S. Yu
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1812-1826 (2014)
Summary: Different cancer cell compartments often communicate through soluble factors to facilitate tumor growth. Glioma stem cells (GSCs) are a subset of tumor cells that resist standard therapy to contribute to disease progression. How GSCs employ
Externí odkaz:
https://doaj.org/article/2083a50321224e64bca9da501aa446ba
Autor:
Justin D. Lathia, Meizhang Li, Maksim Sinyuk, Alvaro G. Alvarado, William A. Flavahan, Kevin Stoltz, Ann Mari Rosager, James Hale, Masahiro Hitomi, Joseph Gallagher, Qiulian Wu, Jody Martin, Jason G. Vidal, Ichiro Nakano, Rikke H. Dahlrot, Steinbjørn Hansen, Roger E. McLendon, Andrew E. Sloan, Shideng Bao, Anita B. Hjelmeland, Christian T. Carson, Ulhas P. Naik, Bjarne Kristensen, Jeremy N. Rich
Publikováno v:
Cell Reports, Vol 6, Iss 1, Pp 117-129 (2014)
Stem cells reside in niches that regulate the balance between self-renewal and differentiation. The identity of a stem cell is linked with the ability to interact with its niche through adhesion mechanisms. To identify targets that disrupt cancer ste
Externí odkaz:
https://doaj.org/article/1a5b47c77ca3454db06e203949d37170
Autor:
Jean A. Bernatchez, Michael Coste, Sungjun Beck, Grace A. Wells, Lucas A. Luna, Alex E. Clark, Zhe Zhu, David Hecht, Jeremy N. Rich, Christal D. Sohl, Byron W. Purse, Jair L. Siqueira-Neto
Publikováno v:
Viruses, Vol 11, Iss 4, p 365 (2019)
Zika virus (ZIKV), an emerging flavivirus that causes neurodevelopmental impairment to fetuses and has been linked to Guillain-Barré syndrome continues to threaten global health due to the absence of targeted prophylaxis or treatment. Nucleoside ana
Externí odkaz:
https://doaj.org/article/8bc9c934f52a44aa9e549f9117d62e4d
Autor:
Sungjun Beck, Zhe Zhu, Michelli F. Oliveira, Davey M. Smith, Jeremy N. Rich, Jean A. Bernatchez, Jair L. Siqueira-Neto
Publikováno v:
Viruses, Vol 11, Iss 4, p 338 (2019)
Zika virus (ZIKV), which is associated with microcephaly in infants and Guillain-Barré syndrome, reemerged as a serious public health threat in Latin America in recent years. Previous high-throughput screening (HTS) campaigns have revealed several p
Externí odkaz:
https://doaj.org/article/da8fe8fcc9534c39ae580a1451c99509