Zobrazeno 11 - 20
of 86
pro vyhledávání: '"Jeremie Boucher"'
Autor:
Weikang Cai, Masaji Sakaguchi, Andre Kleinridders, Gonzalo Gonzalez-Del Pino, Jonathan M. Dreyfuss, Brian T. O’Neill, Alfred K. Ramirez, Hui Pan, Jonathon N. Winnay, Jeremie Boucher, Michael J. Eck, C. Ronald Kahn
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to diff
Externí odkaz:
https://doaj.org/article/c27316e5cd6942f09a89e65936cda8b3
Autor:
Matthew J. Harms, Qian Li, Sunjae Lee, Cheng Zhang, Bengt Kull, Stefan Hallen, Anders Thorell, Ida Alexandersson, Carolina E. Hagberg, Xiao-Rong Peng, Adil Mardinoglu, Kirsty L. Spalding, Jeremie Boucher
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 213-225.e5 (2019)
Summary: White adipose tissue (WAT) is a central factor in the development of type 2 diabetes, but there is a paucity of translational models to study mature adipocytes. We describe a method for the culture of mature white adipocytes under a permeabl
Externí odkaz:
https://doaj.org/article/d72acb327cce4a36b182a5b30c145d83
Autor:
Dustin K Bauknight, Victoria Osinski, Siva Sai Krishna Dasa, Anh T Nguyen, Melissa A Marshall, Julia Hartman, Matthew Harms, Gavin O'Mahony, Jeremie Boucher, Alexander L Klibanov, Coleen A McNamara, Kimberly A Kelly
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224917 (2019)
Targeted nanoparticle delivery is a promising strategy for increasing efficacy and limiting side effects of therapeutics. When designing a targeted liposomal formulation, the in vivo biodistribution of the particles must be characterized to determine
Externí odkaz:
https://doaj.org/article/2da99baf72954ed7b9b321d93ecc7b32
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity
Autor:
Carolina E. Hagberg, Qian Li, Maria Kutschke, Debajit Bhowmick, Endre Kiss, Irina G. Shabalina, Matthew J. Harms, Olga Shilkova, Viviana Kozina, Jan Nedergaard, Jeremie Boucher, Anders Thorell, Kirsty L. Spalding
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2746-2756.e5 (2018)
Summary: Adipocytes, once considered simple lipid-storing cells, are rapidly emerging as complex cells with many biologically diverse functions. A powerful high-throughput method for analyzing single cells is flow cytometry. Several groups have attem
Externí odkaz:
https://doaj.org/article/dedbec0eb51f44e3b6ff06acbc581ec7
Autor:
Yazmin Macotela, Brice Emanuelli, Anneli M Bång, Daniel O Espinoza, Jeremie Boucher, Kirk Beebe, Walter Gall, C Ronald Kahn
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21187 (2011)
Environmental factors, such as the macronutrient composition of the diet, can have a profound impact on risk of diabetes and metabolic syndrome. In the present study we demonstrate how a single, simple dietary factor--leucine--can modify insulin resi
Externí odkaz:
https://doaj.org/article/784ca3cebe5542fb8f6c21b7a69605b2
Autor:
Ritesh K. Baboota, Aidin Rawshani, Laurianne Bonnet, Xiangyu Li, Hong Yang, Adil Mardinoglu, Tamar Tchkonia, James L. Kirkland, Anne Hoffmann, Arne Dietrich, Jeremie Boucher, Matthias Blüher, Ulf Smith
Publikováno v:
Nature Metabolism. 4:1007-1021
The role of hepatic cell senescence in human non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is not well understood. To examine this, we performed liver biopsies and extensive characterization of 58 individuals with
Autor:
Ida Alexandersson, Nahida Arifen, Firoozeh Salehzadeh, Anders Thorell, Carolina E. Hagberg, Jeremie Boucher, Kirsty L. Spalding, Qian Li, Ping Chen, Niels Krämer, Matthew J. Harms, Carole Knibbe, Shuai Lang, Helena Silva Cascales, Eleni Terezaki, Mervi T. Hyvönen, Myriam Aouadi, Maria Kutschke
Publikováno v:
Nature Medicine
Nature Medicine, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
Nature Medicine, Nature Publishing Group, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
Nature Medicine, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
Nature Medicine, Nature Publishing Group, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
International audience; Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both adipocyte progenitor differen
Autor:
Tobias Kroon, Therese Hagstedt, Ida Alexandersson, Annett Ferm, Marie Petersson, Stefanie Maurer, Bader Zarrouki, Kristina Wallenius, Nicholas D. Oakes, Jeremie Boucher
Publikováno v:
Science Translational Medicine. 14
Circadian rhythms play a critical role in regulating metabolism, including daily cycles of feeding/fasting. Glucokinase (GCK) is central for whole-body glucose homeostasis and oscillates according to a circadian clock. GCK activators (GKAs) effective
Autor:
TOBIAS KROON, THERESE HAGSTEDT, IDA ALEXANDERSSON, ANNETT FERM, MARIE PETERSSON, STEFANIE MAURER, BADER ZARROUKI, KRISTINA WALLENIUS, NICHOLAS D. OAKES, JEREMIE BOUCHER
Publikováno v:
Diabetes. 71
Circadian rhythms play critical roles in regulating metabolism, including daily feeding/fasting periods and oscillating expressions of certain genes. Glucokinase (Gck) , expressed in the liver and pancreas, is central for whole-body glucose homeostas
Autor:
Miguel A. Lanaspa, C. Ronald Kahn, Samir Softic, Senad Divanovic, Richard J. Johnson, Kimber L. Stanhope, Jeremie Boucher
Publikováno v:
Crit Rev Clin Lab Sci
Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk factor for development of obesity and its complications, such as fatty liver disease and insulin resistance. Recently, there has been a paradigm shift and