Zobrazeno 61 - 70
of 77
pro vyhledávání: '"Jane L. Grogan"'
Autor:
Hélène Bour-Jordan, Jane L. Grogan, Julie A. Auger, Qizhi Tang, Jeffrey A. Bluestone, Richard M. Locksley
Publikováno v:
Nature immunology. 4(2)
The relative importance of the cytokine milieu versus cytolytic T lymphocyte-associated antigen 4 (CTLA-4) and T cell receptor signal strength on T cell differentiation remains unclear. Here we have generated mice deficient for signal transducer and
Autor:
Richard M. Locksley, Jane L. Grogan
Publikováno v:
Current opinion in immunology. 14(3)
Recent studies raise the possibility that T helper (Th) polarization may be attributable to generalized activation and regulated silencing rather than regulated activation of target cytokine genes. The binding of transcription factors GATA-3 or T-bet
Publikováno v:
The Journal of infectious diseases. 177(5)
Antigen-specific cellular immune responses were examined in persons previously infected with Schistosoma haematobium and who were, 2 years after chemotherapy, either free from infection (n = 17) or reinfected (n = 20). Proliferation to adult worm ant
Autor:
Hossam Ghoneim, Jane L. Grogan, André M. Deelder, Maria Yazdanbakhsh, Peter Rotmans, Mo-Quen Klinkert
Publikováno v:
Parasite immunology. 19(5)
Human schistosome infections are chronic in nature and elevated IgG4 levels are associated with length of exposure. To examine how structure, localization and dynamics of exposure of a protein to the immune system can affect antibody isotype expressi
Autor:
Jim Xiao, Priscilla Horn, K. Basu, John C. Davis, Ann Herman, Zheng Su, An Song, William P Kennedy, J. A. Simon-Campos, Jane L. Grogan, Michael J. Townsend, M. Derby
Publikováno v:
Annals of the Rheumatic Diseases. 72:A617.2-A618
Background Pateclizumab (formerly MLTA3698A), a novel humanized IgG1 antibody against soluble and membrane isoforms of lymphotoxin-alpha, is being investigated as a targeted therapy for rheumatoid arthritis (RA). Objectives To compare the efficacy an
Autor:
An Song, Ann Herman, S. Iyer, Saloumeh K Fischer, Jane L. Grogan, Michael J. Townsend, John C. Davis, William P Kennedy, Marna Williams
Publikováno v:
Annals of the Rheumatic Diseases. 72:A429.1-A429
Background Lymphotoxin (LT)-α, a member of the TNF superfamily, is required for lymph node development and recruitment of B and T cells into lymph nodes via induction of CXCL13 and CCL19 ([1][1]). LTα has been implicated in the development of ectop
Autor:
Maria Yazdanbakhsh, Jane L. Grogan, Wolfram G. Metzger, Benjamin Mordmüller, Peter G. Kremsner, A.M. Deelder, G.J. van Dam
Publikováno v:
The Journal of infectious diseases. 173(5)
Specific IgG4 and IgE responses and polyclonal cytokine profiles were studied in 110 Schistosoma haematobium-infected persons before and 5 weeks after chemotherapy. Pretreatment IgG4 responses to soluble egg antigen (SEA) correlated with intensity of
Autor:
Diana Luca, Bernadette Rojkovich, Jim Xiao, Meina T. Tang, Jane L. Grogan, John C. Davis, Brinda Emu, June H. Lee, Carolyn Offutt, Marna Williams
Publikováno v:
Arthritis Research & Therapy
Introduction Pateclizumab (MLTA3698A) is a humanized mAb against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis. This study was conducted
Autor:
Kurt Schroeder, Mccutcheon Krista, Victoria Pham, Judy Young, David Arnott, Camellia W. Adams, Vineet Bafna, Allen Nguyen, Jane L. Grogan, Natalie Castellana, Jennie R. Lill, Kristin Harden
Publikováno v:
PROTEOMICS - Clinical Applications. 5:473-473
A mouse hybridoma antibody directed against a member of the tumour necrosis factor (TNF)-superfamily, lymphotoxin-alpha (LT-α), was isolated from stored mouse ascites and purified to homogeneity. After more than a decade of storage the genetic mater
Autor:
Jane L Grogan, Xin Yu
Publikováno v:
The Journal of Immunology. 182:33.29-33.29
TIGIT is a co-regulatory molecule expressed on regulatory, memory and activated naïve T cells. Poliovirus receptor (PVR, CD155) was identified as the high-affinity receptor for TIGIT. TIGIT can induce immunoregulatory dendritic cells via ligation o