Zobrazeno 21 - 30
of 77
pro vyhledávání: '"Jane L. Grogan"'
Autor:
Shilpa Keerthivasan, Chungkee Poon, Richard Bourgon, Marcus Ballinger, Romain Banchereau, Hina Iftikhar, Avantika S. Chitre, Amelia Au-Yeung, Zora Modrusan, Patrick Caplazi, Ying-Jiun J. Chen, Leonard D. Goldstein, Jane L. Grogan, Chikara Takahashi, Lélia Delamarre, Sanjeev Mariathasan, Thomas D. Wu, Mahrukh Huseni, Shravan Madireddi, Ira Mellman, Ivette Estay, Meghna Das Thakur, Patrícia de Almeida, William E. O'Gorman
Publikováno v:
Cancer Immunology Research. 9:PO084-PO084
Upon encountering their cognate antigens, T cells can undergo clonal expansion to produce multiple copies of a cell with a shared T cell receptor (TCR). Despite the fundamental role of clonal expansion in cancer immunity, little is known about its re
Autor:
Gerhard F. Weinbauer, Akihiro Arima, Chris Schuetz, Cynthia Woods, Hong Wang, Jane L. Grogan, Thomas Gelzleichter, Yutaka Chihaya, Gary Cain, Gunnar Habermann, Jim Xiao
Publikováno v:
Reproductive Toxicology. 63:82-95
An enhanced embryo-fetal development study was conducted in cynomolgus monkeys using pateclizumab, a humanized IgG1 monoclonal antibody (mAb) targeting lymphotoxin-alpha. Pateclizumab administration between gestation days (GD) 20 and 132 did not indu
Autor:
Vily Panoutsakopoulou, Maria Aggelakopoulou, Evangelina Kourepini, Nikolaos Paschalidis, Davina Camargo Madeira Simoes, Jane L. Grogan
Publikováno v:
The Journal of Immunology. 196:3570-3580
T cell Ig and ITIM domain receptor (TIGIT), expressed on T, NK, and regulatory T cells, is known as an inhibitory molecule that limits autoimmunity, antiviral and antitumor immunity. In this report, we demonstrate that TIGIT enhances Th2 immunity. TI
Autor:
Yonglei Shang, Sean B. Joseph, Konnie Urban, Saloumeh K Fischer, Saileta Prabhu, Vikas K. Sharma, Jane L. Grogan, Eugene Y. Chiang, Robert F. Kelley, Charles Andrew Boswell, Yong Ying, Isidro Hötzel, Leslie A. Khawli, Devin Tesar, Sheila Ulufatu, Daniela Bumbaca Yadav
Publikováno v:
Journal of Biological Chemistry. 290:29732-29741
The pharmacokinetic (PK) behavior of monoclonal antibodies in cynomolgus monkeys (cynos) is generally translatable to that in humans. Unfortunately, about 39% of the antibodies evaluated for PKs in cynos have fast nonspecific (or non-target-mediated)
Autor:
Scott B. Lovitch, Zhabiz Solhjou, Indira Guleria, Reza Abdi, Martina M. McGrath, Mayuko Uehara, Paolo Fiorina, Liwei Jiang, Omar H. Maarouf, Baharak Bahmani, Peter T. Sage, Osman A. Yilmam, Jonathan S. Bromberg, Naima Banouni, Jane L. Grogan, Vivek Kasinath
Publikováno v:
JCI Insight. 3
The contribution of the kidney-draining lymph node (KLN) to the pathogenesis of ischemia-reperfusion injury (IRI) of the kidney and its subsequent recovery has not been explored in depth. In addition, the mechanism by which repetitive IRI contributes
Autor:
Jane L. Grogan, Ruina Li, Edna F. Choo, Sarah M. Bronner, Maureen Beresini, Jonathan Maher, Patrick Cyr, Yingjie Li, Thomas Hunsaker, Brian K. Albrecht, Colin Masui, Kevin R Clark, Yingqing Ran, Jeremy Murray, Terry Crawford, Xiaorong Liang, Fei Wang, F. Anthony Romero, Xiaocang Wei, Alexander M. Taylor, Georgia Hatzivassiliou, Kyle Clagg, Kwong Wah Lai, Karen E. Gascoigne, Le An, Steven Magnuson, Mark Merchant, John S. Wai, Zhongguo Chen, Jiangpeng Liao, Vickie Tsui, Emily Chan, Kevin X. Chen, Wenfeng Liu, Wei Huang, Dong Yu, Stefan G. Koenig, Susan Kaufman, Xiaoyu Zhu, Gladys de Leon Boenig, Justin Ly, Denise E. de Almeida Nagata, Bing-Yan Zhu
Publikováno v:
Journal of medicinal chemistry. 60(22)
Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. We recently disclosed in vivo chemical tool 1 (GNE-272) for the bromodomain of CBP that was moderately potent a
Autor:
Dan L. Eaton, Bryan Irving, Yagai Yang, Henry Chiu, Xin Yu, Jane L. Grogan, Laetitia Comps-Agrar, Jason A. Hackney, Vincent Javinal, Mahrukh Huseni, Robert J. Johnston, Summer Park
Publikováno v:
Cancer Cell. 26:923-937
SummaryTumors constitute highly suppressive microenvironments in which infiltrating T cells are “exhausted” by inhibitory receptors such as PD-1. Here we identify TIGIT as a coinhibitory receptor that critically limits antitumor and other CD8+ T
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0180154 (2017)
PLoS ONE, Vol 12, Iss 7, p e0180154 (2017)
Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel function, patch clamp electrophysiology is considered the gold standard by providing the ultima
Autor:
Thomas Davis, Patrick Soon-Shiong, Edward Cha, Prasad S. Adusumilli, Jane L. Grogan, Charles G. Drake, Adi Diab, Rom Leidner, Adrian Bot, Gordon J. Freeman, Bryan Irving, Salil Patel, Ramy Ibrahim, Daniel S. Chen, David Tuck, Elizabeth E. Evans, Shane A. Olwill, Mark Cornfeld, Thomas W. Dubensky, Frédéric Triebel, Roger D. Dansey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-9 (2017)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
This report is a summary of ‘New Cancer Immunotherapy Agents in Development’ program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November 9, 2016 in National Harbor, Maryland
Autor:
Michelle Nannini, Jeong M. Kim, Deepak Sampath, Robert J. Newman, Sairy Hernandez, Soyoung Oh, Meron Roose-Girma, Rebecca Hong Thibodeau, Min Xu, Summer Park, Ira Mellman, Hyang Mi Lee, Jing Qing, Xiangnan Du, Søren Warming, Jane L. Grogan, Armando Navarro
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 80-94 (2018)
Summary: We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood and critical to its assessment as a viable drug target. We identify kinase-depende