Zobrazeno 41 - 50
of 323
pro vyhledávání: '"James Travis"'
Autor:
Jerzy Silberring, Adam Dubin, Jan Potempa, Marcin Bugno, Daniel C. Nelson, James Travis, Agnieszka Banbula, Paweł Mak
Publikováno v:
Journal of Biological Chemistry. 274:9246-9252
Porphyromonas gingivalis possesses a complex proteolytic system, which is essential for both its growth and evasion of host defense mechanisms. In this report we characterized, both at a protein and genomic level, a novel peptidase of this system wit
Publikováno v:
Journal of Biological Chemistry. 274:12245-12251
Periodontal disease is characterized by inflammation of the periodontium manifested by recruitment of neutrophils, which can degranulate, releasing powerful proteinases responsible for destruction of connective tissues, and eventual loss of tooth att
Publikováno v:
Clinical Infectious Diseases. 28:456-465
It has been demonstrated that the Porphyromonas gingivalis cysteine proteinases (gingipains) activate and/or degrade a broad range of host proteins. Inactivation of gingipains R prior to infection of mice results in a decrease in the virulence of P.
Publikováno v:
FEBS Letters. 440:282-286
Gingipains are the major cysteine proteinases synthesized by Porphyromonas gingivalis which, in soluble form, are able to initially convert IL-8 (77 amino acid residues) to a more potent species truncated at the amino terminus, followed by slow degra
Autor:
Jay F. Mouser, Emily B. Hak, James Travis Methvin, David A. Kuhl, Roland N. Dickerson, Lawrence J. Hak
Publikováno v:
Nutrition. 14:678-682
N-methylhistidine (3-meH) is endogenously released during muscle catabolism and serves as a marker of protein turnover. In rats > 85% of 3-meH is excreted in the urine as the N-acetyl derivative. It has been reported that the percent of non-acetylate
Autor:
Nancy Matheson, James Travis
Publikováno v:
Journal of Biological Chemistry. 273:16771-16777
Although the mesquite plant (Prosopis velutina) is not as widely distributed as some other allergenic species, its pollen can induce serious pollinosis in areas where it is localized. We previously isolated and characterized a peptidase from mesquite
Publikováno v:
Journal of Biological Chemistry. 273:6611-6614
Porphyromonas gingivalis is one of the major pathogens associated with adult periodontitis, a major chronic inflammatory disease. Potent proteinases elaborated by these bacteria aid directly and indirectly in both the development of the pathophysiolo
Autor:
James Travis, Dennis A. Bagarozzi
Publikováno v:
Phytochemistry. 47:593-598
Extracts from ragweed pollen grains contain novel trypsin and chymotrypsin-like serine peptidases which are described in this report. The molecular mass of the chymotrypsin-like enzyme was 82 kDa, had a pH optimum near 9.0, and its activity was unaff
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 117:525-529
The defensive secretion produced in the metathoracic tracheal glands of the grasshoppers, Romalea guttata and Taeniopoda eques , contains a diversity of proteinase inhibitors. The exudate contains inhibitors of trypsin, chymotrypsin, cathepsin G, pap
Publikováno v:
Journal of Biological Chemistry. 272:16062-16067
The effect of two arginine-specific cysteine proteinases (gingipain Rs) from Porphyromonas gingivalis, a causative bacterium of adult periodontitis, on human blood coagulation was investigated. Activated partial thromboplastin time and prothrombin ti