Zobrazeno 31 - 40
of 77
pro vyhledávání: '"Jae J. Song"'
Autor:
So Y. Kim, Bo K. Sun, Sujin Choi, Jae J. Song, Hoan N. Nguyen, Hye Jin Choi, Seeun Oh, Yong J. Lee, Joo Hang Kim
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to activate mitogen-activated protein kinases (MAPKs) depending on caspase and mammalian sterile 20-like kinase 1 activations. However, the upstream molecule of MAPKs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c65566c90effa191f4b761bc0419ee
https://europepmc.org/articles/PMC3041593/
https://europepmc.org/articles/PMC3041593/
Publikováno v:
International journal of oncology. 38(1)
We previously observed that TRAIL induces acquired TRAIL resistance coinciding with increased Akt phosphorylation brought about by the Src-PI3K-Akt signaling pathways and mediated by c-Cbl. c-Cbl, a ubiquitously expressed cytoplasmic adaptor protein,
We have previously observed that TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces acquired TRAIL resistance by increasing Akt phosphorylation and Bcl-xL expression. In this study, we report that Src, c-Cbl, and PI3K are involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a051ad1b1f43151b19b67b005d5126
https://europepmc.org/articles/PMC2965849/
https://europepmc.org/articles/PMC2965849/
Publikováno v:
The Journal of biological chemistry. 282(1)
Previous studies have shown that repeated application of TRAIL induces acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Using human prostate adenocarcinoma DU-145 and human pancreatic carcinoma MiaPaCa-2 cells a
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Cellular signalling. 19(3)
Exposure of mammalian cells to ultraviolet (UV) light or glucose deprivation activates c-Jun NH 2 -terminal protein kinase (JNK). However, the exact mechanism by which UV induces JNK activation is not yet understood completely. Previously, we have ob
Autor:
Dongxu Kang, Hye Jin Choi, Eun Kyung Kim, So Y. Kim, Seungha Lee, Jae J. Song, Sujin Kang, Joo Hang Kim
Publikováno v:
Cancer Research. 74:694-694
Gemcitabine as the standard chemotherapy agent to pancreatic cancer has proved effective; however, the response rate remains at 5.4% and the 5-year survival rate is extremely poor. Due to the shortcomings of gemcitabine and the presence of gemcitabin
Publikováno v:
The Journal of biological chemistry. 280(49)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be selective in the induction of apoptosis in cancer cells with minimal toxicity to normal tissues. However, not all cancers are sensitive to TRAIL-mediated apoptosis.
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of cellular biochemistry. 92(6)
Death-associated protein (Daxx) deletion mutant (aa 501–625) has been known to be an inducer of apoptosis. In this study, we observed that the Bax-dependent mitochondrial death signaling pathway plays an important role in Daxx501–625-induced apop
Publikováno v:
Experimental cell research. 293(1)
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL/APO-2L), a member of the tumor necrosis factor (TNF) gene family, is considered as one of the most promising cancer therapeutic agents due to its ability to selectively kill tumor cells.
Autor:
Joo Hang Kim, Eun Ah Cho, Jae J. Song, Eun Hee Kim, Dae Bong Kang, Chae O K Yun, Joohyuk Sohn
Publikováno v:
Human gene therapy. 14(17)
Recombinant adenovirus (Ad) has emerged as the vector system of choice in cancer gene therapy. Its full utility, however, has been limited because of the low efficiency of adenovirus-mediated gene transfer to cancer cells - the main reason being that