Zobrazeno 61 - 70
of 84
pro vyhledávání: '"Jacqueline McBride"'
Autor:
J.-P. Stephan, Marna Williams, Franklin Fuh, Andy C. Rawstron, Matthew J. Cullen, Fiona Bennett, Reina N. Fuji, Allen J. Ebens, Jacqueline McBride, Jeffrey Lau, Tom Januario, Andrew Jack, Christine Tan, MaryAnn Go, R de Tute, Alane M. Gray, Kirsten Achilles Poon, Shang-Fan Yu, Changchun Du, Andrew Polson, Yan Wu, Jo Anne Hongo, Rong Deng, Helga Raab, Saileta Prabhu, Randy Dere, Wei-Ching Liang
Publikováno v:
Leukemia. 24:1566-1573
Antibody-drug conjugates (ADCs) are potent cytotoxic drugs linked to antibodies through chemical linkers, and allow specific targeting of drugs to neoplastic cells. The expression of CD22 is limited to B-cells, and we show that CD22 is expressed on t
Autor:
Allen Nguyen, Kent Wong, Ari Chakrabarti, Jenny Jiang, Sheila Ulufatu, Shannon Liu, Nicole Valle, Summer Park, Min Xu, Carrie Rosenberger, Veronica Anania, Jacqueline McBride
Publikováno v:
The Journal of Immunology. 200:60.16-60.16
Viral quantification serves as a valid biomarker for detecting Influenza A infection however viral burden is not closely associated with disease severity or clinical outcomes. Biomarkers reflecting the status of the host immune response are needed to
Autor:
Allen J. Ebens, Xiaoyan Shi, Mark S. Dennis, Mary Ann T. Go, Jagath Reddy Junutula, Dorothy French, Nancy Yu, Andy C. Rawstron, Fiona Bennett, Jeffrey Lau, Andrew Jack, David Dornan, Peng Yue, Jacqueline McBride, Hartmut Koeppen, Andrew Polson, Bing Zheng, Shang-Fan Yu, Yvonne Chen, Dan L. Eaton, Kristi Elkins
Publikováno v:
Blood. 114:2721-2729
Here we describe the generation of an antibody–drug conjugate (ADC) consisting of a humanized anti-CD79b antibody that is conjugated to monomethylauristatin E (MMAE) through engineered cysteines (THIOMABs) by a protease cleavable linker. By using f
Autor:
Henry Chiu, Wyne P. Lee, Linda Rangell, Fong Sherman, Asja Praetor, Jacqueline McBride, James Cupp, Lorena Cabote, Dimitry M. Danilenko
Publikováno v:
Blood. 113:1919-1928
Hematopoietic stem cells (HSCs) have the capacity to self-renew and continuously differentiate into all blood cell lineages throughout life. At each branching point during differentiation, interactions with the environment are key in the generation o
Autor:
Romeo Maciuca, Christina Chaivorapol, Timothy W. Behrens, Alexander R. Abbas, Michael J. Townsend, Jacqueline McBride, Paul Brunetta, William P Kennedy, Bruce C. Richardson, Alyssa Morimoto, Kristen Wolslegel, John C. Davis, Wei Tew
Publikováno v:
Lupus Science & Medicine
Objectives The interferon (IFN) signature (IS) in patients with systemic lupus erythematosus (SLE) includes over 100 genes induced by type I IFN pathway activation. We developed a method to quantify the IS using three genes—the IS metric (ISM)—an
Autor:
Gina C. Jager, Sharon South, Chris Murriel, Shigemi Kinoshita, Garry P. Nolan, Jacqueline McBride, Dennis J. Mitchell, Omar D. Perez, L. A. Herzenberg
Publikováno v:
Nature Immunology. 4:1083-1092
Leukocyte functional antigen 1 (LFA-1), with intercellular adhesion molecule ligands, mediates T cell adhesion, but the signaling pathways and functional effects imparted by LFA-1 are unclear. Here, intracellular phosphoprotein staining with 13-dimen
Publikováno v:
Cellular Immunology. 215:162-172
IL-10 is a potent inhibitor of T-cell activation and has tolerizing effects on these cells. These effects are primarily mediated via modulation of antigen presenting cell function. Here, it is demonstrated that IL-10 completely inhibits LPS-induced D
Etrolizumab Treatment Improves Histological Activity as Assessed by the Robarts Histopathology Index
Autor:
Udayasankar Arulmani, Alexis Scherl, Brian G. Feagan, Laurent Peyrin-Biroulet, Gert De Hertogh, Jacqueline McBride, Romeo Maciuca, David T. Rubin
Publikováno v:
Gastroenterology. 152:S600
Autor:
U Arulmani, Romeo Maciuca, Jacqueline McBride, G. De Hertogh, Alexis Scherl, L Peyrin-Biroulet, Brian G. Feagan, David T. Rubin
Publikováno v:
Journal of Crohn's and Colitis. 11:S317-S317
Background: Etrolizumab, an anti-β7 mAb targeting α4β7 and αEβ7 integrins, showed efficacy and safety vs placebo (PBO) during 10 weeks of induction in patients with moderate-to-severe UC in the phase 2 trial, EUCALYPTUS. Because a reduction in h
Autor:
Cary M. Looney, Jacqueline McBride, Romeo Maciuca, Franklin Fuh, Teresa Ramirez-Montagut, Wei Tew, Mary E. Keir
Publikováno v:
Journal of Crohn's and Colitis. 11:S296-S296