Zobrazeno 91 - 100
of 475
pro vyhledávání: '"Jack Satsangi"'
Publikováno v:
Inflammatory bowel diseases. 26(11)
The intestinal mucosa represents a unique environment where the coordinated function of diverse epithelial, mesenchymal, and immune cells maintains a physiologically balanced environment in the presence of gut microbiota. The intestinal mucosa plays
Publikováno v:
F1000Research
Crohn’s disease and ulcerative colitis are increasingly prevalent, relapsing and remitting inflammatory bowel diseases (IBDs) with variable disease courses and complications. Their aetiology remains unclear but current evidence shows an increasingl
Autor:
Edouard Louis, Catarina Frias Gomes, Thomas P. Chapman, Jean-Frederic Colombel, Jack Satsangi
Publikováno v:
The Lancet Gastroenterology & Hepatology
Treatment strategies for inflammatory bowel disease (IBD) focus on the induction and long-term maintenance of deep remission to avoid complications of active disease and improve long-term outcomes. Medical therapies for IBD, notably the increasingly
Autor:
Jack Satsangi
Epidemiological data, particularly concordance rates in twin pairs and in multiply affected families, provide strong evidence that both genetic and environmental influences are important in the development of the chronic intestinal inflammation chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f1b12147e35ae9b2deba51e7be0d51
https://doi.org/10.1080/000163501750266800
https://doi.org/10.1080/000163501750266800
Autor:
I. D. R. Arnott, Linda Smith, Elaine R. Nimmo, Jack Satsangi, Hazel E. Drummond, Colin L. Noble
Introduction: Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to inflammatory bowel disease (IBD) in Germany. Haplotype D, notably characterised by the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33be18ff20886c2055e1d7f2c868f289
https://doi.org/10.1136/gut.2005.066621
https://doi.org/10.1136/gut.2005.066621
Considerable progress has been made in the last decade in studies of the genetics of the inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Epidemiological data, notably concordance rates in twin pairs and sibling pairs, have provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3c550dd78e6a4d6d99442ea85b0c41
https://doi.org/10.1053/bega.2002.0349
https://doi.org/10.1053/bega.2002.0349
Advances in molecular genetics have aided our understanding of disease pathogenesis and have helped in making therapeutic decisions. Knowledge is still evolving, however, and care must be taken in extrapolating research-based data to genetic testing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43fc355343ca0bec294744e102c036c
https://ora.ox.ac.uk/objects/uuid:9b33fd0a-c996-4e6c-8b80-170527a24132
https://ora.ox.ac.uk/objects/uuid:9b33fd0a-c996-4e6c-8b80-170527a24132
Autor:
Illaria Bonetti, Nicholas T. Ventham, Marie-Alice Meuwis, Edouard Louis, Olivier Kitten, Nadege Prel, Stephanie Scott, Rahul Kalla, Jack Satsangi, Marcela Chavez
Publikováno v:
Journal of Crohns and Colitis
Journal of Crohn's and Colitis
Journal of Crohn's and Colitis
The European Union offers opportunities for high-level of funding of collaborative European research. Calls are regularly published: after the end of the FP7 funding programme the new round of Horizon 2020 calls started in 2015. Several topics are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356bd7cf70c28b7aaf460f2908fae9c6
https://ora.ox.ac.uk/objects/uuid:11142695-451e-48ba-9153-c0f7d15aec18
https://ora.ox.ac.uk/objects/uuid:11142695-451e-48ba-9153-c0f7d15aec18
Autor:
J. van Limbergen, Niall Anderson, Jack Satsangi, Richard K Russell, Linda Smith, Malcolm G. Dunlop, Mikael Lördal, Charlie W. Lees, Hazel E. Drummond, Susan M. Farrington, I. D. R. Arnott, Gamal Mahdi, Lawrence T. Weaver, U. Sjöqvist, Paraic McGrogan, Peter M. Gillett, Leif Törkvist, W M Bisset, David C. Wilson, K. Hassan, Elaine R. Nimmo
Background: NOD1/CARD4 and NOD2/CARD15 are both intracellular pattern-recognition receptors. The NOD1/CARD4 gene lies within a previously described inflammatory bowel disease (IBD) locus (7p14). An association has been suggested between the NOD1/CARD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df819b725b1cd6053199211207d24581
https://doi.org/10.1002/ibd.20124
https://doi.org/10.1002/ibd.20124
Autor:
Niall Anderson, Linda Smith, Elaine R. Nimmo, Hazel E. Drummond, David C. Wilson, Johan Van Limbergen, Ian D. Arnott, G. Davies, Jack Satsangi, Richard K Russell
Both NOD1/CARD4 and NOD2/CARD15 are intracellular pattern-recognition receptors involved in the innate immune response. Germline NOD2/CARD15 variation has a definite effect on susceptibility to Crohn's disease (CD) and phenotype, although this contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b3266a36fabd6941c1f463d9dc8817
https://ora.ox.ac.uk/objects/uuid:0670a211-d684-45c3-b3f8-61aebe4fdaff
https://ora.ox.ac.uk/objects/uuid:0670a211-d684-45c3-b3f8-61aebe4fdaff