Zobrazeno 51 - 60
of 176
pro vyhledávání: '"Jürgen G. Okun"'
Autor:
Christian Thiel, Ali Majlesara, Giovanni Frongia, Arash Saffari, Jürgen G. Okun, Dezfouli Sepher Abbasi, Negin Gharabaghi, Arianeb Mehrabi, Rodrigo Vianna, Patrick Günther
Publikováno v:
Journal of Gastrointestinal Surgery. 23:331-338
Small bowel transplantation (SBTX) in children receiving larger grafts from adults can be challenging because of size mismatch. The aim of the present study was to assess whether a simultaneous serial transverse enteroplasty (STEP) can address the pr
Autor:
Georg F. Hoffmann, Stine Christ, Sylvia Richter, Péter Monostori, Thomas Opladen, Brigitte Schmidt-Mader, Glynis Klinke, Jürgen G. Okun, Angels García-Cazorla, Rafael Artuch, Nenad Blau
Publikováno v:
Journal of inherited metabolic diseaseREFERENCES. 43(4)
BACKGROUND Laboratory investigations of cerebrospinal fluid (CSF) are essential when suspecting an inborn error of metabolism (IEM) involving neurological features. Available tests are currently performed on different analytical platforms, requiring
Autor:
Iris Oezen, Michael Kilian, Michael O. Breckwoldt, Mario L. Suvà, Michael C. Burger, Mirco Friedrich, Khwab Sanghvi, Karl H. Plate, Magdalena Kramer, Sevin Turcan, Daniel Hänggi, Niklas Thon, Daniel Schrimpf, Stefan Kaulfuss, Katrin Deumelandt, Jochen Meyer, Richard Harbottle, Jürgen G. Okun, Theresa Bunse, Edward W. Green, Tobias Kessler, Miriam Ratliff, Michael Platten, Jana K. Sonner, Brandon Nicolay, Marion Dorsch, Michael Weller, Anna von Landenberg, Ruslan Al-Ali, Mya Steadman, Matthias Bozza, Holger Hess-Stumpp, Karen Bieback, Dongwei Zhu, Stefan Pusch, Cyril Neftel, Wolfgang Wick, Jessica Eisel, Benedikt Wiestler, Antje Habel, Minou Nadji-Ohl, Axel Benner, Christel Herold-Mende, Anna S. Berghoff, Dalia Alansary, Patrick N. Harter, Lukas Bunse, Kelly Marsh, Gernot Poschet, Barbara A. Niemeyer, Andreas von Deimling, Daniel P. Cahill, Felix Sahm, Simone Karcher-Bausch, Matthias Preusser, Stefanie Uhlig
Publikováno v:
Nature Medicine. 24:1192-1203
The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation. Here, we identify an additional activity of R-2-HG: tumor cell-derived R-2-HG is taken up
Autor:
Glynis Klinke, Jürgen G. Okun, Georg F. Hoffmann, Patrik Feyh, Gwendolyn Gramer, Junmin Fang-Hoffmann, Péter Monostori
Publikováno v:
World Journal of Pediatrics. 14:470-481
Newborn screening (NBS) in Germany currently includes 15 target disorders. Recent diagnostic improvements suggest an extension of the screening panel. Since August 2016, a prospective study evaluating 26 additional target disorders (25 metabolic diso
Autor:
Peter P. Nawroth, Norbert Gretz, Tjeerd P. Sijmonsma, Johannes Backs, Gernot Poschet, Adam J. Rose, Rüdiger Hell, Eva-Maria Weis, Sven W. Sauer, Ralf H. Adams, Hermann-Joseph Gröne, Jacqueline Taylor, Stefanie E. Herberich, Iris Moll, Jürgen G. Okun, Stephan Herzig, Lorenz H. Lehmann, Markus Jabs, Giuseppina Federico, Roland M. Schmid, Hellmut G. Augustin, Andreas Fischer, Minhong Yan, Carolin Mogler
Publikováno v:
Circulation 137, 2592-2608 (2018)
Background: Nutrients are transported through endothelial cells before being metabolized in muscle cells. However, little is known about the regulation of endothelial transport processes. Notch signaling is a critical regulator of metabolism and angi
Autor:
Arcangela Iuso, Nicola A. Grzeschik, Holger Prokisch, Iris Barshack, Muhamad Kumbar, Bart Kanon, Thomas Schwarzmayr, Gal Dubnov-Raz, Dorothea Haas, Riccardo Berutti, Bader Alhaddad, Marit Wiersma, Zeev Perles, Ben Pode-Shakked, Georg F. Hoffmann, Mathias Grigat, Tal Tirosh, Caterina Terrile, Elisa Mastantuono, Tim M. Strom, Jürgen G. Okun, Marina Rubinshtein, Matthias C. Braunisch, Yair Anikster, Shachar Abudi, Camilla Avivi, Ana C. Messias, Amir Vardi, Brundel Bianca Johanna Josephina Maria, Ody C. M. Sibon, Eran Eyal, Dina Marek-Yagel, Tobias B. Haack, Yishay Salem, Thomas Meitinger, A Volkov, Ortal Barel, Hans Joachim Schüller
Publikováno v:
American Journal of Human Genetics, 102(6), 1018-1030. CELL PRESS
Am. J. Hum. Genet. 102, 1018-1030 (2018)
The American Journal of Human Genetics
Iuso, A, Wiersma, M, Schüller, H J, Pode-Shakked, B, Marek-Yagel, D, Grigat, M, Schwarzmayr, T, Berutti, R, Alhaddad, B, Kanon, B, Grzeschik, N A, Okun, J G, Perles, Z, Salem, Y, Barel, O, Vardi, A, Rubinshtein, M, Tirosh, T, Dubnov-Raz, G, Messias, A C, Terrile, C, Barshack, I, Volkov, A, Avivi, C, Eyal, E, Mastantuono, E, Kumbar, M, Abudi, S, Braunisch, M, Strom, T M, Meitinger, T, Hoffmann, G F, Prokisch, H, Haack, T B, Brundel, B J J M, Haas, D, Sibon, O C M & Anikster, Y 2018, ' Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy ', American journal of human genetics, vol. 102, no. 6, pp. 1018-1030 . https://doi.org/10.1016/j.ajhg.2018.03.022
American journal of human genetics, 102(6), 1018-1030. Cell Press
Am. J. Hum. Genet. 102, 1018-1030 (2018)
The American Journal of Human Genetics
Iuso, A, Wiersma, M, Schüller, H J, Pode-Shakked, B, Marek-Yagel, D, Grigat, M, Schwarzmayr, T, Berutti, R, Alhaddad, B, Kanon, B, Grzeschik, N A, Okun, J G, Perles, Z, Salem, Y, Barel, O, Vardi, A, Rubinshtein, M, Tirosh, T, Dubnov-Raz, G, Messias, A C, Terrile, C, Barshack, I, Volkov, A, Avivi, C, Eyal, E, Mastantuono, E, Kumbar, M, Abudi, S, Braunisch, M, Strom, T M, Meitinger, T, Hoffmann, G F, Prokisch, H, Haack, T B, Brundel, B J J M, Haas, D, Sibon, O C M & Anikster, Y 2018, ' Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy ', American journal of human genetics, vol. 102, no. 6, pp. 1018-1030 . https://doi.org/10.1016/j.ajhg.2018.03.022
American journal of human genetics, 102(6), 1018-1030. Cell Press
Coenzyme A (CoA) is an essential metabolic cofactor used by around 4% of cellular enzymes. Its role is to carry and transfer acetyl and acyl groups to other molecules. Cells can synthesize CoA de novo from vitamin B5 (pantothenate) through five conse
Autor:
Thomas Opladen, Georg F. Hoffmann, Sylvia Richter, Julia Rossmann, Stine Christ, Stefan Kölker, Glynis Klinke, Jürgen G. Okun, Pamela M. Okun
Publikováno v:
Neuropediatrics.
Autor:
Maximilian Breuer, Georg F. Hoffmann, Joris Probst, Matthias Zielonka, Stefan Kölker, Matthias Carl, Jürgen G. Okun
Publikováno v:
Neuropediatrics.
Autor:
Hans-Peter Hammes, Michael Mendler, Peter P. Nawroth, Andrea Schlotterer, Thomas Fleming, Jürgen G. Okun, Christin Riedinger, Stephan Herzig
Publikováno v:
J. Biol. Chem. 293, 4845-4859 (2018)
The enzyme AICAR-transformylase/IMP cyclohydrolase (ATIC) catalyzes the last two steps of purine de novo synthesis. It metabolizes 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), which is an AMP analogue, leading to activation of AMP-activated
Autor:
Claus Dieter Langhans, Jürgen G. Okun, Philipp Koch, Kai Schledzewski, Sebastian A. Wohlfeil, Iris Augustin, Michael Boutros, Hellmut G. Augustin, Thomas Leibing, Johanna Zierow, Cyrill Géraud, Victor Olsavszky, Sergij Goerdt
Publikováno v:
Hepatology. 68:707-722
Postnatal liver development is characterized by hepatocyte growth, proliferation and functional maturation. Notably, canonical Wnt signaling in hepatocytes has been identified as an important regulator of final adult liver size and metabolic liver zo