Zobrazeno 51 - 60
of 1 669
pro vyhledávání: '"Ignacio I. Wistuba"'
Autor:
Jing Lin, Roza Zandi, Ruping Shao, Jian Gu, Yuanqin Ye, Jing Wang, Yang Zhao, Alexander Pertsemlidis, Ignacio I. Wistuba, Xifeng Wu, Jack A. Roth, Lin Ji
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We dete
Externí odkaz:
https://doaj.org/article/b2795e546e554183a50a6e56dd7ff1b4
Autor:
Mark J. Schliekelman, Chad J. Creighton, Brandi N. Baird, Yulong Chen, Priyam Banerjee, Neus Bota-Rabassedas, Young-Ho Ahn, Jonathon D. Roybal, Fengju Chen, Yiqun Zhang, Dhruva K. Mishra, Min P. Kim, Xin Liu, Barbara Mino, Pamela Villalobos, Jaime Rodriguez-Canales, Carmen Behrens, Ignacio I. Wistuba, Samir M. Hanash, Jonathan M. Kurie
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the clinical outcome of lung cancer patients have not been full
Externí odkaz:
https://doaj.org/article/b98c31b4556442fb996362e7c46fd3c2
Autor:
Maithili P. Dalvi, Lei Wang, Rui Zhong, Rahul K. Kollipara, Hyunsil Park, Juan Bayo, Paul Yenerall, Yunyun Zhou, Brenda C. Timmons, Jaime Rodriguez-Canales, Carmen Behrens, Barbara Mino, Pamela Villalobos, Edwin R. Parra, Milind Suraokar, Apar Pataer, Stephen G. Swisher, Neda Kalhor, Natarajan V. Bhanu, Benjamin A. Garcia, John V. Heymach, Kevin Coombes, Yang Xie, Luc Girard, Adi F. Gazdar, Ralf Kittler, Ignacio I. Wistuba, John D. Minna, Elisabeth D. Martinez
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1669-1684 (2017)
Although non-small cell lung cancer (NSCLC) patients benefit from standard taxane-platin chemotherapy, many relapse, developing drug resistance. We established preclinical taxane-platin-chemoresistance models and identified a 35-gene resistance signa
Externí odkaz:
https://doaj.org/article/b799525f4c5f4794b566dfe7987f5ae9
Autor:
Alexandre Reuben, Christine N. Spencer, Peter A. Prieto, Vancheswaran Gopalakrishnan, Sangeetha M. Reddy, John P. Miller, Xizeng Mao, Mariana Petaccia De Macedo, Jiong Chen, Xingzhi Song, Hong Jiang, Pei-Ling Chen, Hannah C. Beird, Haven R. Garber, Whijae Roh, Khalida Wani, Eveline Chen, Cara Haymaker, Marie-Andrée Forget, Latasha D. Little, Curtis Gumbs, Rebecca L. Thornton, Courtney W. Hudgens, Wei-Shen Chen, Jacob Austin-Breneman, Robert Szczepaniak Sloane, Luigi Nezi, Alexandria P. Cogdill, Chantale Bernatchez, Jason Roszik, Patrick Hwu, Scott E. Woodman, Lynda Chin, Hussein Tawbi, Michael A. Davies, Jeffrey E. Gershenwald, Rodabe N. Amaria, Isabella C. Glitza, Adi Diab, Sapna P. Patel, Jianhua Hu, Jeffrey E. Lee, Elizabeth A. Grimm, Michael T. Tetzlaff, Alexander J. Lazar, Ignacio I. Wistuba, Karen Clise-Dwyer, Brett W. Carter, Jianhua Zhang, P. Andrew Futreal, Padmanee Sharma, James P. Allison, Zachary A. Cooper, Jennifer A. Wargo
Publikováno v:
npj Genomic Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
Melanoma: Tumor differences within a patient may explain heterogeneous responses Patients with metastatic melanoma display molecular and immune differences across tumor sites associated with differential drug responses. A team led by Jennifer Wargo f
Externí odkaz:
https://doaj.org/article/95f4f8da81aa4220b7ea3fea4b7af4b6
Autor:
Yu Liu, Jianjun Zhang, Lin Li, Guangliang Yin, Jianhua Zhang, Shan Zheng, Hannah Cheung, Ning Wu, Ning Lu, Xizeng Mao, Longhai Yang, Jiexin Zhang, Li Zhang, Sahil Seth, Huang Chen, Xingzhi Song, Kan Liu, Yongqiang Xie, Lina Zhou, Chuanduo Zhao, Naijun Han, Wenting Chen, Susu Zhang, Longyun Chen, Wenjun Cai, Miaozhong Shen, Ningzhi Xu, Shujun Cheng, Huanming Yang, J. Jack Lee, Arlene Correa, Junya Fujimoto, Carmen Behrens, Chi-Wan Chow, William N. William, John V. Heymach, Waun Ki Hong, Stephen Swisher, Ignacio I. Wistuba, Jun Wang, Dongmei Lin, Xiangyang Liu, P. Andrew Futreal, Yanning Gao
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Some patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and
Externí odkaz:
https://doaj.org/article/b47899a5b32046278f07cf214de45ffc
Autor:
Hye-Jin Boo, Hye-Young Min, Hyun-Ji Jang, Hye Jeong Yun, John Kendal Smith, Quanri Jin, Hyo-Jong Lee, Diane Liu, Hee-Seok Kweon, Carmen Behrens, J. Jack Lee, Ignacio I. Wistuba, Euni Lee, Waun Ki Hong, Ho-Young Lee
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The binding of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to nicotinic acetylcholine receptors (nAChRs) induces calcium signalling. Here the authors show that NKK-induced calcium influx in airway epithelial cells
Externí odkaz:
https://doaj.org/article/b677a8e4f78945a8ba09e04a707207e1
Publikováno v:
Cancers, Vol 13, Iss 4, p 820 (2021)
Lung cancer is consistently the leading cause of cancer-related death worldwide, and it ranks as the second most frequent type of new cancer cases diagnosed in the United States, both in males and females. One subtype of lung cancer, small cell lung
Externí odkaz:
https://doaj.org/article/8835178a4de64a4bb76ee4d1e2f2c4a2
Autor:
Mahesh S. Padanad, Georgia Konstantinidou, Niranjan Venkateswaran, Margherita Melegari, Smita Rindhe, Matthew Mitsche, Chendong Yang, Kimberly Batten, Kenneth E. Huffman, Jingwen Liu, Ximing Tang, Jaime Rodriguez-Canales, Neda Kalhor, Jerry W. Shay, John D. Minna, Jeffrey McDonald, Ignacio I. Wistuba, Ralph J. DeBerardinis, Pier Paolo Scaglioni
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1614-1628 (2016)
KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood. We report that mutant
Externí odkaz:
https://doaj.org/article/accd4720f8274f44bb862c81497526a0
Autor:
Johannes F. Fahrmann, Xiangying Mao, Ehsan Irajizad, Hiroyuki Katayama, Michela Capello, Ichidai Tanaka, Taketo Kato, Ignacio I. Wistuba, Anirban Maitra, Edwin J. Ostrin, Samir M. Hanash, Jody Vykoukal
Publikováno v:
Cancers, Vol 12, Iss 5, p 1147 (2020)
Using a combination of mass-spectrometry and aptamer array-based proteomics, we characterized the protein features of circulating extracellular vesicles (EVs) in the context of lung (LUAD) and pancreatic ductal (PDAC) adenocarcinomas. We profiled EVs
Externí odkaz:
https://doaj.org/article/0a77736ca66b4e6ca8ca3e080309f9f4
Autor:
Rama Soundararajan, Jared J. Fradette, Jessica M. Konen, Stacy Moulder, Xiang Zhang, Don L. Gibbons, Navin Varadarajan, Ignacio I. Wistuba, Debasish Tripathy, Chantale Bernatchez, Lauren A. Byers, Jeffrey T. Chang, Alejandro Contreras, Bora Lim, Edwin Roger Parra, Emily B. Roarty, Jing Wang, Fei Yang, Michelle Barton, Jeffrey M. Rosen, Sendurai A. Mani
Publikováno v:
Cancers, Vol 11, Iss 5, p 714 (2019)
Over the last decade, both early diagnosis and targeted therapy have improved the survival rates of many cancer patients. Most recently, immunotherapy has revolutionized the treatment options for cancers such as melanoma. Unfortunately, a significant
Externí odkaz:
https://doaj.org/article/d50a7c35b228495387cc40f85e911354