Zobrazeno 41 - 50
of 1 669
pro vyhledávání: '"Ignacio I. Wistuba"'
Autor:
Brian C. Haynes, Richard A. Blidner, Robyn D. Cardwell, Robert Zeigler, Shobha Gokul, Julie R. Thibert, Liangjing Chen, Junya Fujimoto, Vassiliki A. Papadimitrakopoulou, Ignacio I. Wistuba, Gary J. Latham
Publikováno v:
Translational Oncology, Vol 12, Iss 6, Pp 836-845 (2019)
We developed and characterized a next-generation sequencing (NGS) technology for streamlined analysis of DNA and RNA using low-input, low-quality cancer specimens. A single-workflow, targeted NGS panel for non–small cell lung cancer (NSCLC) was des
Externí odkaz:
https://doaj.org/article/a8950f9ea35a4e3aab0cccfb16ee6416
Autor:
Smruthy Sivakumar, F. Anthony San Lucas, Yasminka A. Jakubek, Tina L. McDowell, Wenhua Lang, Noah Kallsen, Shanna Peyton, Gareth E. Davies, Junya Fukuoka, Yasushi Yatabe, Jianjun Zhang, P. Andrew Futreal, Jerry Fowler, Junya Fujimoto, Erik A. Ehli, Ernest T. Hawk, Ignacio I. Wistuba, Humam Kadara, Paul Scheet
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 296-303 (2019)
Background: Genomic investigation of atypical adenomatous hyperplasia (AAH), the only known precursor lesion to lung adenocarcinomas (LUAD), presents challenges due to the low mutant cell fractions. This necessitates sensitive methods for detection o
Externí odkaz:
https://doaj.org/article/3d142109ee244f4bba060226618823d3
Autor:
Pingjun Chen, Siba El Hussein, Fuyong Xing, Muhammad Aminu, Aparajith Kannapiran, John D. Hazle, L. Jeffrey Medeiros, Ignacio I. Wistuba, David Jaffray, Joseph D. Khoury, Jia Wu
Publikováno v:
Cancers, Vol 14, Iss 10, p 2398 (2022)
Identifying the progression of chronic lymphocytic leukemia (CLL) to accelerated CLL (aCLL) or transformation to diffuse large B-cell lymphoma (Richter transformation; RT) has significant clinical implications as it prompts a major change in patient
Externí odkaz:
https://doaj.org/article/f4f84b4faad14bbaa57f512e0acb33db
Autor:
Mauricio S. Caetano, Maya Hassane, Hieu T. Van, Emmanuel Bugarin, Amber M. Cumpian, Christina L. McDowell, Carolina Gonzalez Cavazos, Huiyuan Zhang, Shanshan Deng, Lixia Diao, Jing Wang, Scott E. Evans, Carmen Behrens, Ignacio I. Wistuba, Susan A. W. Fuqua, Huang Lin, Laura P. Stabile, Stephanie S. Watowich, Humam Kadara, Seyed Javad Moghaddam
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Proinflammatory and immunomodulatory events that drive development of K-ras mutant lung adenocarcinoma (LUAD) are poorly understood. Here they develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout mouse model and show a sex-speci
Externí odkaz:
https://doaj.org/article/a75e60d748374ccbaa270592719a5d9b
Autor:
Zeya Wang, Shaolong Cao, Jeffrey S. Morris, Jaeil Ahn, Rongjie Liu, Svitlana Tyekucheva, Fan Gao, Bo Li, Wei Lu, Ximing Tang, Ignacio I. Wistuba, Michaela Bowden, Lorelei Mucci, Massimo Loda, Giovanni Parmigiani, Chris C. Holmes, Wenyi Wang
Publikováno v:
iScience, Vol 9, Iss , Pp 451-460 (2018)
Summary: Transcriptome deconvolution in cancer and other heterogeneous tissues remains challenging. Available methods lack the ability to estimate both component-specific proportions and expression profiles for individual samples. We present DeMixT,
Externí odkaz:
https://doaj.org/article/04660eb59a434b3aaa6071ef528c231e
Autor:
Edwin R. Parra, Pamela Villalobos, Carmen Behrens, Mei Jiang, Apar Pataer, Stephen G. Swisher, William N. William, Jiexin Zhang, Jack Lee, Tina Cascone, John V. Heymach, Marie-Andrée Forget, Cara Haymaker, Chantale Bernatchez, Neda Kalhor, Annikka Weissferdt, Cesar Moran, Jianjun Zhang, Ara Vaporciyan, Don L. Gibbons, Boris Sepesi, Ignacio I. Wistuba
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-11 (2018)
Abstract Background The clinical efficacy observed with inhibitors of programed cell death 1/programed cell death ligand 1 (PD-L1/PD-1) in cancer therapy has prompted studies to characterize the immune response in several tumor types, including lung
Externí odkaz:
https://doaj.org/article/a0fbee6e3c0d4cdda806783e081be8ef
Autor:
David L. Rimm, Gang Han, Janis M. Taube, Eunhee S. Yi, Julia A. Bridge, Douglas B. Flieder, Robert Homer, Anja C. Roden, Fred R. Hirsch, Ignacio I. Wistuba, Lajos Pusztai
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-3 (2019)
Abstract The companion diagnostic test for checkpoint inhibitor immune therapy is an immunohistochemical test for PD-L1. The test has been shown to be reproducible for expression in tumor cells, but not in immune cells. Immune cells were used in the
Externí odkaz:
https://doaj.org/article/36bf31ee90614449952120245cb37456
Autor:
Edwin R. Parra, Naohiro Uraoka, Mei Jiang, Pamela Cook, Don Gibbons, Marie-Andrée Forget, Chantale Bernatchez, Cara Haymaker, Ignacio I. Wistuba, Jaime Rodriguez-Canales
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Immune-profiling is becoming an important tool to identify predictive markers for the response to immunotherapy. Our goal was to validate multiplex immunofluorescence (mIF) panels to apply to formalin-fixed and paraffin-embedded tissues usin
Externí odkaz:
https://doaj.org/article/48f248acce0f4bd68d965c4ec09c5ab2
Autor:
Xin Hu, Junya Fujimoto, Lisha Ying, Junya Fukuoka, Kazuto Ashizawa, Wenyong Sun, Alexandre Reuben, Chi-Wan Chow, Nicholas McGranahan, Runzhe Chen, Jinlin Hu, Myrna C. Godoy, Kazuhiro Tabata, Kishio Kuroda, Lei Shi, Jun Li, Carmen Behrens, Edwin Roger Parra, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Humam Kadara, Paul Scheet, Emily Roarty, Edwin Justin Ostrin, Xu Wang, Brett W. Carter, Mara B. Antonoff, Jianhua Zhang, Ara A. Vaporciyan, Harvey Pass, Stephen G. Swisher, John V. Heymach, J. Jack Lee, Ignacio I. Wistuba, Waun Ki Hong, P. Andrew Futreal, Dan Su, Jianjun Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/65cbdc5d34a842e5a0fd745c093e43dc
Autor:
Guangchun Han, Ansam Sinjab, Kieko Hara, Warapen Treekitkarnmongkol, Patrick Brennan, Kyle Chang, Elena Bogatenkova, Beatriz Sanchez-Espiridion, Carmen Behrens, Luisa M. Solis, Boning Gao, Luc Girard, Jianjun Zhang, Boris Sepesi, Tina Cascone, Lauren A. Byers, Don L. Gibbons, Jichao Chen, Seyed Javad Moghaddam, Edwin J. Ostrin, Paul Scheet, Junya Fujimoto, Jerry Shay, John V. Heymach, John D. Minna, Steven Dubinett, Ignacio I. Wistuba, Christopher S. Stevenson, Avrum E. Spira, Linghua Wang, Humam Kadara
Publikováno v:
Cancers, Vol 13, Iss 6, p 1250 (2021)
The novel coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Severely symptomatic COVID-19 is associated with lung inflammation, pneumonia, and respiratory failure, thereby raising concerns of elevated risk of COVID-19-associated
Externí odkaz:
https://doaj.org/article/54bf6a35709648349b0d9a29fd8dafef