Zobrazeno 21 - 30
of 48
pro vyhledávání: '"Huwate Yeerna"'
Autor:
Bradford Siegele, Yardena Samuels, J. Guy Lyons, J. Silvio Gutkind, Vachan Vadmal, Moraima Zaida, Zhiyong Wang, Lynn Vitale-Cross, Pablo Tamayo, Huwate Yeerna, Kun-Liang Guan, Alfredo A. Molinolo, Daniel Martin, Sok Ching Cheong, Juan Luis Callejas Valera, Ramiro Iglesias-Bartolome, Scott M. Lippman, Rick F. Thorne, Xiaodong Feng, Toshiro Moroishi, Maria Sol Degese
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature communications, vol 9, iss 1
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications
Dysregulation of the Hippo signaling pathway and the consequent YAP1 activation is a frequent event in human malignancies, yet the underlying molecular mechanisms are still poorly understood. A pancancer analysis of core Hippo kinases and their candi
Autor:
Amy E. Schade, James A. DeCaprio, Ole Gjoerup, Jong Wook Kim, Pablo Tamayo, Christian Berrios, Guillaume Adelmant, Huwate Yeerna, Nathaniel Gray, Amanda Balboni Iniguez, Kim Stegmaier, Michael P. Washburn, Laurence Florens, Miju Kim, Emily Damato, Selene K. Swanson, William C. Hahn, Jarrod A. Marto
Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST) or mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c68ae0340fe6238a14faa4e3e9cd7ee
Autor:
Dinh Diep, Brian M. Reilly, Tiffany N. Tanaka, Pablo Tamayo, Rafael Bejar, Kun Zhang, Huwate Yeerna
Publikováno v:
Blood advances, vol 3, iss 19
Recurrent mutations implicate several epigenetic regulators in the early molecular pathobiology of myelodysplastic syndromes (MDS). We hypothesized that MDS subtypes defined by DNA methylation (DNAm) patterns could enhance our understanding of MDS di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3602f3d486f3c57fdf60115d7c1a8576
https://escholarship.org/uc/item/19d4b7cd
https://escholarship.org/uc/item/19d4b7cd
Autor:
Pablo Tamayo, Timothy V. Pham, Amélie Boichard, Razelle Kurzrock, Igor F. Tsigelny, Garrett M. Frampton, Aaron M. Goodman, Scott M. Lippman, Huwate Yeerna
Publikováno v:
OncoImmunology, Vol 8, Iss 3 (2019)
Oncoimmunology, vol 8, iss 3
Oncoimmunology
Oncoimmunology, vol 8, iss 3
Oncoimmunology
Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance. PD-L1/PD-1 checkpoint immunotherapy is a highly p
Autor:
J. Silvio Gutkind, Nijiro Nohata, Victoria Wu, Huwate Yeerna, Olivier Harismendy, Joshua Chiou, Robert B. Russell, Pablo Tamayo, Francesco Raimondi, Asuka Inoue
Publikováno v:
The Journal of biological chemistry, vol 294, iss 29
G protein–coupled receptors (GPCRs) are the largest gene family of cell membrane–associated molecules mediating signal transmission, and their involvement in key physiological functions is well-established. The ability of GPCRs to regulate a vast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae378de1db36e9feb6084bda21b293d8
http://www.jbc.org/content/294/29/11062.full.pdf
http://www.jbc.org/content/294/29/11062.full.pdf
Autor:
Lisa Kim, Pablo Tamayo, Vincent A. Miller, Catriona Jamieson, Razelle Kurzrock, Matthew J. Wieduwilt, Aaron M. Goodman, Tariq I. Mughal, Jo-Anne Vergilio, Michael Y. Choi, Natalie Galanina, Huwate Yeerna, Carolyn Mulroney, Rafael Bejar
Publikováno v:
Cancers, Vol 11, Iss 1, p 11 (2018)
Cancers
Cancers, vol 11, iss 1
Volume 11
Issue 1
Cancers
Cancers, vol 11, iss 1
Volume 11
Issue 1
Background: The translation of genomic discoveries to the clinic is the cornerstone of precision medicine. However, incorporating next generation sequencing (NGS) of hematologic malignancies into clinical management remains limited. Methods: We descr
Autor:
Xuefeng Zhang, Huwate Yeerna, Anne N. Murphy, Xingyu Wu, J. Silvio Gutkind, Zhiyong Wang, Scott M. Lippman, Victoria Wu, Panomwat Amornphimoltham, Qianming Chen, Yusuke Goto, Toshinori Ando, Pablo Tamayo
Publikováno v:
Cancer research. 79(17)
Metformin may reduce the progression of head and neck squamous cell carcinoma (HNSCC); however, whether metformin acts by altering the host metabolism or targets cancer-initiating cells remains poorly understood. This gap in knowledge has prevented t
Autor:
Huwate Yeerna, Bharat A. Panuganti, Pablo Tamayo, Akihiro Sakai, Koji Ebisumoto, Yusuke Goto, Sunny Haft, J. Silvio Gutkind, Takahito Fukusumi, Andrew B. Sharabi, Jacqueline A. Hubbard, Yuki Saito, William Kim, Shuling Ren, Sayed Sadat, Mizuo Ando, Theresa Guo, Joseph A. Califano, Chao Liu
Publikováno v:
Clin Cancer Res
Purpose: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in parallel with increased marijuana use in the United States. Our study is designed to define the
Autor:
Katherine Licon, John Paul Shen, Ana Bojorquez-Gomez, Andrew M. Gross, Chu Ping Qiu, Huwate Yeerna, Jia L. Xu, Rohith Srivas, Haico van Attikum, Robert W. Sobol, Vignesh Sivaganesh, Su Ming Sun, Eric J. Jaehnig, Daniel Pekin, Jianfeng Li, Kristin Klepper, Trey Ideker
Publikováno v:
Oncotarget
Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we
Autor:
Zhiyong Wang, J. Silvio Gutkind, Qianming Chen, Ayush Kishore, Evi Kostenis, Eytan Ruppin, Xiaodong Feng, Huwate Yeerna, Joo Sang Lee, Marcello Maggiolini, Pablo Tamayo, Gabriele M. König, Nadia Arang, Jonathan A. Pachter, Simone Lubrano, Damiano Cosimo Rigiracciolo, David D. Schlaepfer
Publikováno v:
Molecular Cancer Research. 18:A20-A20
YAP overactivation is an essential molecular event for cancer initiation and growth of most solid tumors, but pharmacologic targeting of the YAP or Hippo pathway has been proven to be challenging. In this regard, YAP activity is also required for ste