Zobrazeno 61 - 70
of 1 053
pro vyhledávání: '"Hiroshi Handa"'
Autor:
Matteo G. Della Porta, Cristina Picone, Cristiana Pascutto, Luca Malcovati, Hideto Tamura, Hiroshi Handa, Magdalena Czader, Sylvie Freeman, Paresh Vyas, Anna Porwit, Leonie Saft, Theresia M. Westers, Canan Alhan, Claudia Cali, Arjan A. van de Loosdrecht, Kiyoyuki Ogata
Publikováno v:
Haematologica, Vol 97, Iss 8 (2012)
Background The current World Health Organization classification of myelodysplastic syndromes is based morphological evaluation of bone marrow dysplasia. In clinical practice, the reproducibility of the recognition of dysplasia is usually poor especia
Externí odkaz:
https://doaj.org/article/20ee582402cc4feabe7c0712214443dd
Autor:
Yuki Ito, Takumi Ito, Satoki Karasawa, Teruya Enomoto, Akihiro Nashimoto, Yasuyoshi Hase, Satoshi Sakamoto, Tsuneyo Mimori, Yoshihisa Matsumoto, Yuki Yamaguchi, Hiroshi Handa
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50481 (2012)
Bisphenol A (BPA) forms the backbone of plastics and epoxy resins used to produce packaging for various foods and beverages. BPA is also an estrogenic disruptor, interacting with human estrogen receptors (ER) and other related nuclear receptors. Neve
Externí odkaz:
https://doaj.org/article/d89d2b7b2537431c81d9cb2eaed7b013
Autor:
Miho Oue, Hiroshi Handa, Yasunori Matsuzaki, Kazutomo Suzue, Hirokazu Murakami, Hirokazu Hirai
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e51015 (2012)
The murine stem cell virus (MSCV) promoter exhibits activity in mouse hematopoietic cells and embryonic stem cells. We generated transgenic mice that expressed enhanced green fluorescent protein (GFP) under the control of the MSCV promoter. We obtain
Externí odkaz:
https://doaj.org/article/662599353d804bebac6f6437a3dec132
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6918 (2009)
The stalling of RNA polymerase II (RNAPII) at the promoters of many genes, including developmental regulators, stress-responsive genes, and HIVLTR, suggests transcription elongation as a critical regulatory step in addition to initiation. Spt5, the l
Externí odkaz:
https://doaj.org/article/598a39fb19c5406babc07002875f9303
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e3070 (2008)
Haem is a prosthetic group for haem proteins, which play an essential role in oxygen transport, respiration, signal transduction, and detoxification. In haem biosynthesis, the haem precursor protoporphyrin IX (PP IX) must be accumulated into the mito
Externí odkaz:
https://doaj.org/article/bbb2c7af426d478cace38344c5a8c6f9
Publikováno v:
Folia Pharmacologica Japonica. 158:16-20
TAR DNA-binding protein 43 (TDP-43) is an evolutionarily conserved RNA/DNA-binding protein that is nuclear-enriched in healthy cells, but deposited in the cytoplasm as aggregates in affected neurons in certain neurodegenerative diseases, including am
Publikováno v:
CHEM. SOC. REV.. 51:6234-6250
Progress in strategies aimed at breaking down therapeutic target proteins has led to a paradigm shift in drug discovery. Thalidomide and its derivatives are the only protein degraders currently used in clinical practice. Our understanding of the mole
Autor:
Kisyo Mihara, Tatsuya Onishi, Sachiko Matsuda, Satoshi Sakamoto, Hiroshi Handa, Akihiro Kuwahata, Masaki Sekino, Moriaki Kusakabe, Yuko Kitagawa
Publikováno v:
IEEJ Transactions on Fundamentals and Materials. 142:236-242
Spinal motor neurons (SMNs) are the primary target of degeneration in amyotrophic lateral sclerosis (ALS). Degenerating motor neurons accumulate cytoplasmic TAR DNA-binding protein 43 (TDP-43) aggregates in most ALS cases. This SMN pathology can occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cabffffbe7809d86f4169db69a486f0
https://doi.org/10.1101/2023.05.12.540624
https://doi.org/10.1101/2023.05.12.540624
Autor:
Hideto Tamura, Rimpei Morita, Koiti Inokuchi, Mika Sunakawa-Kii, Hiroshi Handa, Takumi Ito, Junichi Yamamoto, Mariko Ishibashi
We previously showed that the interaction of programmed death-ligand 1 (PD-L1) on multiple myeloma (MM) cells with PD-1 not only inhibits tumor-specific cytotoxic T-lymphocyte activity via the PD-1 signaling pathway but also induces drug resistance v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c24f7df0cc6a46b3d564efeb21b942b
https://doi.org/10.1158/1535-7163.c.6543444.v1
https://doi.org/10.1158/1535-7163.c.6543444.v1