Zobrazeno 31 - 40
of 1 053
pro vyhledávání: '"Hiroshi Handa"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of motor neurons in the brain and spinal cord. Spinal motor neurons align along the spinal cord length within the vertebral column, and ext
Externí odkaz:
https://doaj.org/article/9e9533f958d7407584eb443c5b8923f4
Autor:
Hideki Ando, Tomomi Sato, Takumi Ito, Junichi Yamamoto, Satoshi Sakamoto, Nobuhiro Nitta, Tomoko Asatsuma-Okumura, Nobuyuki Shimizu, Ryota Mizushima, Ichio Aoki, Takeshi Imai, Yuki Yamaguchi, Arnold J. Berk, Hiroshi Handa
Publikováno v:
iScience, Vol 15, Iss , Pp 95-108 (2019)
Summary: Thalidomide is a teratogen that causes multiple malformations in the developing baby through its interaction with cereblon (CRBN), a substrate receptor subunit of the CRL4 E3 ubiquitin ligase complex. CRBN was originally reported as a gene a
Externí odkaz:
https://doaj.org/article/60af45cc9cbd4bfbaae5aca5b107477a
Autor:
Hitoshi Tsugawa, Yasuaki Kabe, Ayaka Kanai, Yuki Sugiura, Shigeaki Hida, Shun’ichiro Taniguchi, Toshio Takahashi, Hidenori Matsui, Zenta Yasukawa, Hiroyuki Itou, Keiyo Takubo, Hidekazu Suzuki, Kenya Honda, Hiroshi Handa, Makoto Suematsu, Matthew K. Waldor
Publikováno v:
PLoS Biology, Vol 18, Iss 9 (2020)
Short-chain fatty acids (SCFAs) produced by gastrointestinal microbiota regulate immune responses, but host molecular mechanisms remain unknown. Unbiased screening using SCFA-conjugated affinity nanobeads identified apoptosis-associated speck-like pr
Externí odkaz:
https://doaj.org/article/56f120bff45342348320ad7fc691a85d
Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology
Autor:
Tatsuya Onishi, Kisyo Mihara, Sachiko Matsuda, Satoshi Sakamoto, Akihiro Kuwahata, Masaki Sekino, Moriaki Kusakabe, Hiroshi Handa, Yuko Kitagawa
Publikováno v:
Cancers, Vol 14, Iss 2, p 364 (2022)
Screening, monitoring, and diagnosis are critical in oncology treatment. However, there are limitations with the current clinical methods, notably the time, cost, and special facilities required for radioisotope-based methods. An alternative approach
Externí odkaz:
https://doaj.org/article/5bb8c2269c4f4646b9b8085ccb1829ab
Autor:
Masaki Sekino, Akihiro Kuwahata, Shunsuke Fujita, Sachiko Matsuda, Miki Kaneko, Shinichi Chikaki, Satoshi Sakamoto, Itsuro Saito, Hiroshi Handa, Moriaki Kusakabe
Publikováno v:
AIP Advances, Vol 10, Iss 2, Pp 025317-025317-7 (2020)
Magnetic immunostaining is a technique used to accelerate the antigen-antibody immunoreaction by increasing the local density of antibody on the surface of a tissue specimen using a magnetic field. The high density of antibody is achieved by applying
Externí odkaz:
https://doaj.org/article/06c8e41c35d144be89551171f5ddd8ce
Autor:
Eriko Koda, Tsuneo Yamashiro, Rintaro Onoe, Hiroshi Handa, Shinya Azagami, Shoichiro Matsushita, Hayato Tomita, Takeo Inoue, Masamichi Mineshita
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243181 (2020)
ObjectivesTo investigate the potential of computed tomography (CT)-based texture analysis and elastographic data provided by endobronchial ultrasonography (EBUS) for differentiating the mediastinal lymphadenopathy by sarcoidosis and small cell lung c
Externí odkaz:
https://doaj.org/article/f67388a2dda843b08152afe240cec7fe
Autor:
Kunio Yanagisawa, Nuanjun Wichukchinda, Naho Tsuchiya, Michio Yasunami, Archawin Rojanawiwat, Hidenori Tanaka, Hiroh Saji, Yoshiyuki Ogawa, Hiroshi Handa, Panita Pathipvanich, Koya Ariyoshi, Pathom Sawanpanyalert
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242438 (2020)
BackgroundMannose-binding lectin (MBL) plays a pivotal role in innate immunity; however, its impact on susceptibility to opportunistic infections (OIs) has not yet been examined in a natural history cohort of people living with HIV/AIDS.MethodsWe use
Externí odkaz:
https://doaj.org/article/75036dfcc3d34a0dbbafbe40c3c5cfdd
Autor:
Masaki Sekino, Akihiro Kuwahata, Akinobu Yoshibe, Kiyotaka Imai, Miki Kaneko, Shinichi Chikaki, Itsuro Saito, Akinori Tsuruma, Satoshi Sakamoto, Hiroshi Handa, Sachiko Matsuda, Moriaki Kusakabe
Publikováno v:
AIP Advances, Vol 10, Iss 1, Pp 015106-015106-6 (2020)
Magnetic immunostaining provides a novel technique for rapid intraoperative diagnosis of cancer metastasis and its characteristics in lymph nodes. Previous studies have shown the effectiveness of this technique using the manual staining process. Howe
Externí odkaz:
https://doaj.org/article/09f7bd11e5084aba964578c170659e22
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 5, Pp 986-987 (2021)
Externí odkaz:
https://doaj.org/article/a571139042f549aeaad095ac08394b3d
Autor:
Yasuaki Kabe, Ikko Koike, Tatsuya Yamamoto, Miwa Hirai, Ayaka Kanai, Ryogo Furuhata, Hitoshi Tsugawa, Erisa Harada, Kenji Sugase, Kazue Hanadate, Nobuji Yoshikawa, Hiroaki Hayashi, Masanori Noda, Susumu Uchiyama, Hiroki Yamazaki, Hirotoshi Tanaka, Takuya Kobayashi, Hiroshi Handa, Makoto Suematsu
Publikováno v:
Cancers, Vol 13, Iss 13, p 3265 (2021)
Progesterone receptor membrane component 1 (PGRMC1) is highly expressed in various cancer cells and contributes to tumor progression. We have previously shown that PGRMC1 forms a unique heme-stacking functional dimer to enhance EGF receptor (EGFR) ac
Externí odkaz:
https://doaj.org/article/654006beb9b7426eb8bcf719a12e0160