Zobrazeno 21 - 30
of 1 053
pro vyhledávání: '"Hiroshi Handa"'
Autor:
Mitsuhito Hirano, Yoichi Imai, Yuta Kaito, Takahiko Murayama, Kota Sato, Tadao Ishida, Junichi Yamamoto, Takumi Ito, Muneyoshi Futami, Masaki Ri, Hiroshi Yasui, Tamami Denda, Yukihisa Tanaka, Yasunori Ota, Masanori Nojima, Yasuhiko Kamikubo, Noriko Gotoh, Shinsuke Iida, Hiroshi Handa, Arinobu Tojo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)
Abstract Background Multiple myeloma (MM) is an incurable disease. The acquisition of resistance to drugs, including immunomodulatory drugs (IMiDs), has a negative effect on its prognosis. Cereblon (CRBN) is a key mediator of the bioactivities of IMi
Externí odkaz:
https://doaj.org/article/f2e71599d7d641fb9ece99c28c22cc0d
Autor:
Rei Ishihara, Tsukasa Oda, Yuki Murakami, Ikuko Matsumura, Saki Watanabe, Yuta Asao, Yuta Masuda, Nanami Gotoh, Tetsuhiro Kasamatsu, Hisashi Takei, Nobuhiko Kobayashi, Nobuo Sasaki, Takayuki Saitoh, Hirokazu Murakami, Hiroshi Handa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2216 (2023)
Tissue inhibitors of metalloproteinases (TIMPs) are endogenous matrix metalloproteinase inhibitors. TIMP1 is produced by cancer cells and has pleiotropic activities. However, its role and source in multiple myeloma (MM) are unclear. Here, we evaluate
Externí odkaz:
https://doaj.org/article/5720de51a97649d0af9e20529b9f3019
Autor:
Yuki Murakami, Kei Kimura-Masuda, Tsukasa Oda, Ikuko Matsumura, Yuta Masuda, Rei Ishihara, Saki Watanabe, Yuko Kuroda, Tetsuhiro Kasamatsu, Nanami Gotoh, Hisashi Takei, Nobuhiko Kobayashi, Takayuki Saitoh, Hirokazu Murakami, Hiroshi Handa
Publikováno v:
Genes, Vol 14, Iss 1, p 100 (2022)
MicroRNAs (miRNAs and miRs) are small (19–25 base pairs) non-coding RNAs with the ability to modulate gene expression. Previously, we showed that the miR-34 family is downregulated in multiple myeloma (MM) as the cancer progressed. In this study, w
Externí odkaz:
https://doaj.org/article/c25c48d1c35c4c5ab476193479063973
Publikováno v:
Thoracic Cancer, Vol 12, Iss 13, Pp 2043-2045 (2021)
Abstract Autofluorescence imaging (AFI) is a technique for detecting early‐stage lung cancer by amplifying the difference in autofluorescence of the bronchial mucosa. However, there are few reports detailing its other applications. Here, we report
Externí odkaz:
https://doaj.org/article/74a3e2a65c614c2bace663c71b14c674
Autor:
Yukitaka Yamasaki, Seido Ooka, Shin Matsuoka, Hayato Tomita, Masanori Hirose, Tomonori Takano, Shotaro Suzuki, Mitsuru Imamura, Hiroshi Handa, Hiroki Nishine, Mumon Takita, Ayu Minoura, Kenichiro Morisawa, Takeo Inoue, Masamichi Mineshita, Kimito Kawahata, Hiromu Takemura, Shigeki Fujitani, Hiroyuki Kunishima
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0276738 (2022)
Presently, coronavirus disease-19 (COVID-19) is spreading worldwide without an effective treatment method. For COVID-19, which is often asymptomatic, it is essential to adopt a method that does not cause aggravation, as well as a method to prevent in
Externí odkaz:
https://doaj.org/article/c8fd494e708b4890bf05d2c99f04e1bb
Autor:
Kei Morikawa, Hirotaka Kida, Hiroshi Handa, Takeo Inoue, Teruomi Miyazawa, Masamichi Mineshita
Publikováno v:
Thoracic Cancer, Vol 11, Iss 5, Pp 1339-1343 (2020)
Programmed cell death‐1 immune checkpoint inhibitor (ICI) antibody has proven to be effective in advanced non‐small cell lung cancer (NSCLC) patients positive for programmed cell death‐1 ligand‐1. However, there are currently no reports which
Externí odkaz:
https://doaj.org/article/afa1ea43f9664740b9b0869d94576698
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Optogenetic approaches for inducing TDP-43 aggregation have been described previously in cellular models. Here the authors develop an approach to optogenetically induce TDP-43 aggregation in vivo using zebrafish to model ALS pathologies.
Externí odkaz:
https://doaj.org/article/7c6b2200d5b548f9a33410547da5f71f
Autor:
Kei Morikawa, Hirotaka Kida, Hiroshi Handa, Takeo Inoue, Hisashi Saji, Junki Koike, Seiji Nakamura, Yoshiharu Sato, Yumi Ueda, Fumihiko Suzuki, Ryo Matoba, Masamichi Mineshita
Publikováno v:
Cancers, Vol 14, Iss 15, p 3784 (2022)
Background: Genetic panel tests require sufficient tissue samples, and therefore, cannot always be performed. Although collecting cytological specimens is easier than tissue collection, there are no validation studies on the diagnostic accuracy of lu
Externí odkaz:
https://doaj.org/article/5a179700e2ee4d02a813b536605bd158
Publikováno v:
Respirology Case Reports, Vol 9, Iss 4, Pp n/a-n/a (2021)
Key message Relapsing polychondritis (RP) often develops into severe tracheobronchial stenosis with malacia. Although tracheal tears rarely occur by intubation, treatment decisions for tears can be difficult due to airway inflammation in RP patients.
Externí odkaz:
https://doaj.org/article/7b2e12ee2fd046398b887f9158852514
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Thalidomide, a sedative drug that was once excluded from the market owing to its teratogenic properties, was later found to be effective in treating multiple myeloma. We had previously demonstrated that cereblon (CRBN) is the target of thalidomide em
Externí odkaz:
https://doaj.org/article/0ce3f32b6c634b1ba0fc8b64cef81290