Zobrazeno 41 - 50
of 1 751
pro vyhledávání: '"Hideyuki Okano"'
Distribution of macrophages in the developing cochlea of the common marmoset, a primate model animal
Autor:
Makoto Hosoya, Tsubasa Kitama, Marie N. Shimanuki, Takanori Nishiyama, Naoki Oishi, Hideyuki Okano, Hiroyuki Ozawa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMacrophages are essential immune cells in the cochlea that contribute to inflammation, tissue repair, and homeostasis. They also play an important role in local cochlear immunity. The developmental immigration and maturation of macrophage
Externí odkaz:
https://doaj.org/article/c9c399abd22d482498925b9d9bd1b91a
Publikováno v:
Frontiers in Neuroanatomy, Vol 17 (2023)
IntroductionThe well-regulated development of the sensory epithelium is essential for hearing. This process involves the specification of a pro-sensory epithelium containing common progenitors that differentiate into hair and supporting cells. Notch
Externí odkaz:
https://doaj.org/article/e2a205f9bec945ff82a7a08f12ac870d
Autor:
Tomoko Sakai, Junichi Hata, Yuta Shintaku, Hiroki Ohta, Kazumi Sogabe, Susumu Mori, Takako Miyabe-Nishiwaki, Hirotaka James Okano, Yuzuru Hamada, Toshiyuki Hirabayashi, Takafumi Minamimoto, Norihiro Sadato, Hideyuki Okano, Kenichi Oishi
Publikováno v:
NeuroImage, Vol 273, Iss , Pp 120096- (2023)
A comparison of neuroanatomical features of the brain between humans and our evolutionary relatives, nonhuman primates, is key to understanding the human brain system and the neural basis of mental and neurological disorders. Although most comparativ
Externí odkaz:
https://doaj.org/article/4efa2e2343ca474b982ddc0a2504c00e
Autor:
Makoto Hosoya, Tsubasa Kitama, Kaho Iwabu, Takanori Nishiyama, Naoki Oishi, Hideyuki Okano, Hiroyuki Ozawa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Stria vascularis is a structure that generates potassium gradients in the cochlea, which is vital for hair cells to convert mechanical sound waves into electrical pulses. The precise development of the stria vascularis and subsequent generat
Externí odkaz:
https://doaj.org/article/5132ec3c15b14ae58879a97f6e7d5380
Autor:
Kentaro Ago, Narihito Nagoshi, Kent Imaizumi, Takahiro Kitagawa, Momotaro Kawai, Keita Kajikawa, Reo Shibata, Yasuhiro Kamata, Kota Kojima, Munehisa Shinozaki, Takahiro Kondo, Satoshi Iwano, Atsushi Miyawaki, Masanari Ohtsuka, Haruhiko Bito, Kenta Kobayashi, Shinsuke Shibata, Tomoko Shindo, Jun Kohyama, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Visualisation of the activity of neural grafts using engineered luciferase provides insights into the integration between the graft and host.
Externí odkaz:
https://doaj.org/article/1123478e34614555b85d810a078f5e88
Autor:
Iki Sonn, Fumiko Honda-Ozaki, Sho Yoshimatsu, Satoru Morimoto, Hirotaka Watanabe, Hideyuki Okano
Publikováno v:
Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-20 (2022)
Abstract Background Microglia are innate immune cells that are the only residential macrophages in the central nervous system. They play vital physiological roles in the adult brain and during development. Microglia are particularly in the spotlight
Externí odkaz:
https://doaj.org/article/d5e6ffb2bec6455b8fe94669a3b35aba
Autor:
Tsubasa Saeki, Sho Yoshimatsu, Mitsuru Ishikawa, Chung-Chau Hon, Ikuko Koya, Shinsuke Shibata, Makoto Hosoya, Chika Saegusa, Kaoru Ogawa, Jay W. Shin, Masato Fujioka, Hideyuki Okano
Publikováno v:
Regenerative Therapy, Vol 20, Iss , Pp 165-186 (2022)
Introduction: Efficient induction of the otic placode, the developmental origin of the inner ear from human pluripotent stem cells (hPSCs), provides a robust platform for otic development and sensorineural hearing loss modelling. Nevertheless, there
Externí odkaz:
https://doaj.org/article/8f164e0c0729489aa06876e4cf1c3290
Autor:
Shota Okura, Honoka Ishii, Ayano Suzuki, Chika Saegusa, Ko Fujiki, Kenshi Sugano, Noriomi Suzuki, Tsubasa Saeki, Saeko Matsuzaki, Hiroyuki Ozawa, Masato Fujioka, Makoto Hosoya, Hideyuki Okano
Publikováno v:
Stem Cell Research, Vol 67, Iss , Pp 103017- (2023)
We report the establishment of two human induced pluripotent stem cell (iPSC) lines from individuals without auditory disorders. Extensive audiometry tests were performed to confirm normal hearing. The generated iPSC lines expressed pluripotency gene
Externí odkaz:
https://doaj.org/article/85537c87e3934ece81c6e1596a1845c1
Publikováno v:
North American Spine Society Journal, Vol 13, Iss , Pp 100184- (2023)
Spinal cord injury (SCI) has been considered to cause sudden, irreversible loss of function in patients. However, developments in stem cell biology and regenerative medicine are changing this conventional notion. Here we reviewed the overview of rege
Externí odkaz:
https://doaj.org/article/28a69005e56c45fc86d16f699253247d
Autor:
Hitomi Ono-Minagi, Tsutomu Nohno, Takashi Serizawa, Yu Usami, Takayoshi Sakai, Hideyuki Okano, Hideyo Ohuchi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13692 (2023)
The vertebrate body comprises four distinct cell populations: cells derived from (1) ectoderm, (2) mesoderm, (3) endoderm, and (4) neural crest cells, often referred to as the fourth germ layer. Neural crest cells arise when the neural plate edges fu
Externí odkaz:
https://doaj.org/article/4e8623c14357479e841e9e4e1bcbc724