Zobrazeno 11 - 20
of 1 751
pro vyhledávání: '"Hideyuki Okano"'
Autor:
Ryohei Takada, Michihiro Toritsuka, Takahira Yamauchi, Rio Ishida, Yoshinori Kayashima, Yuki Nishi, Mitsuru Ishikawa, Kazuhiko Yamamuro, Minobu Ikehara, Takashi Komori, Yuki Noriyama, Kohei Kamikawa, Yasuhiko Saito, Hideyuki Okano, Manabu Makinodan
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background A growing body of evidence suggests that immune dysfunction and inflammation in the peripheral tissues as well as the central nervous system are associated with the neurodevelopmental deficits observed in autism spectrum disorder
Externí odkaz:
https://doaj.org/article/d4371887269c4db7bf95d1b63ee05347
Autor:
Saori Yano-Nashimoto, Anna Truzzi, Kazutaka Shinozuka, Ayako Y. Murayama, Takuma Kurachi, Keiko Moriya-Ito, Hironobu Tokuno, Eri Miyazawa, Gianluca Esposito, Hideyuki Okano, Katsuki Nakamura, Atsuko Saito, Kumi O. Kuroda
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Children’s secure attachment with their primary caregivers is crucial for physical, cognitive, and emotional maturation. Yet, the causal links between specific parenting behaviors and infant attachment patterns are not fully understood. He
Externí odkaz:
https://doaj.org/article/3d6d07b6e58848eb97b4ddcfe58af529
Autor:
Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh
Publikováno v:
Endocrine Journal, Vol 71, Iss 2, Pp 153-169 (2024)
Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, decline
Externí odkaz:
https://doaj.org/article/92235c5b076e4e6488506b52c2421753
Publikováno v:
Spine Surgery and Related Research, Vol 8, Iss 1, Pp 22-28 (2024)
Spinal cord injury (SCI) is a devastating injury that causes permanent neurological dysfunction. To develop a new treatment strategy for SCI, a clinical trial of transplantation of human-induced pluripotent stem cell-derived neural precursor cells (N
Externí odkaz:
https://doaj.org/article/c0f8ccb63a7e425cab8b8aa69dc4bd53
Autor:
Takuma Kurachi, Kazutaka Shinozuka, Chihiro Yoshihara, Saori Yano-Nashimoto, Ayako Y. Murayama, Junichi Hata, Yawara Haga, Hideyuki Okano, Kumi O. Kuroda
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Calcitonin receptor (Calcr) and its brain ligand amylin in the medial preoptic area (MPOA) are found to be critically involved in infant care and social contact behaviors in mice. In primates, however, the evidence is limited to an excitotox
Externí odkaz:
https://doaj.org/article/00ed1f90be054d9cb944ab83c778a3d5
Autor:
Saki Sakakura, Emi Inagaki, Tomoko Sayano, Risa Yamazaki, Noemi Fusaki, Shin Hatou, Masatoshi Hirayama, Kazuo Tsubota, Kazuno Negishi, Hideyuki Okano, Shigeto Shimmura
Publikováno v:
Regenerative Therapy, Vol 24, Iss , Pp 592-601 (2023)
Introduction: Fuchs endothelial corneal dystrophy (FECD) is the leading cause of corneal blindness in developed countries. Corneal endothelial cells in FECD are susceptive to oxidative stress, leading to mitochondrial dysfunction and cell death. Oxid
Externí odkaz:
https://doaj.org/article/7a365db3a838401b9291b1fd913b44dd
Autor:
Chika Saegusa, Hideki Mutai, Tsubasa Saeki, Saeko Matsuzaki, Akifumi Mizukoshi, Shin-ichiro Kitajiri, Tatsuo Matsunaga, Makoto Hosoya, Hideyuki Okano, Masato Fujioka
Publikováno v:
Stem Cell Research, Vol 79, Iss , Pp 103489- (2024)
Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural heari
Externí odkaz:
https://doaj.org/article/7fec7d0c2ef64f9eb5fda29de5d42d28
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Brain aging causes a progressive decline in functional capacity and is a strong risk factor for dementias such as Alzheimer’s disease. To characterize age-related proteomic changes in the brain, we used quantitative proteomics to examine b
Externí odkaz:
https://doaj.org/article/bc970e89361c4dcf81dcfdb162fbc5e6
Autor:
Yu Suematsu, Narihito Nagoshi, Munehisa Shinozaki, Yoshitaka Kase, Yusuke Saijo, Shogo Hashimoto, Takahiro Shibata, Keita Kajikawa, Yasuhiro Kamata, Masahiro Ozaki, Kaori Yasutake, Tomoko Shindo, Shinsuke Shibata, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-17 (2023)
Abstract Background Human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC)-based cell transplantation has emerged as a groundbreaking method for replacing damaged neural cells and stimulating functional recovery, but it
Externí odkaz:
https://doaj.org/article/3e108cd040a0415693c9639aef17b23a
Autor:
Yusaku Katada, Hiromitsu Kunimi, Naho Serizawa, Deokho Lee, Kenta Kobayashi, Kazuno Negishi, Hideyuki Okano, Kenji F. Tanaka, Kazuo Tsubota, Toshihide Kurihara
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 1-13 (2023)
Ectopic induction of optogenetic actuators, such as channelrhodopsin, is a promising approach to restoring vision in the degenerating retina. However, the cell type-specific response of ectopic photoreception has not been well understood. There are l
Externí odkaz:
https://doaj.org/article/2eb99aaf89804103af13347c0cff9850