Zobrazeno 101 - 110
of 126
pro vyhledávání: '"Haydn T. Kissick"'
Publikováno v:
Journal of Clinical Oncology. 35:508-508
508 Background: Loss of co-stimulatory molecules by CD8 T-cells is associated with reduced proliferative and cytotoxic function in chronic viral infections, aging, and cancer. Several lines of evidence suggest that a more functional immune system is
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93231 (2014)
PLoS ONE
PLoS ONE
Here, we sought to determine whether peptide vaccines designed harbor both class I as well as class II restricted antigenic motifs could concurrently induce CD4 and CD8 T cell activation against autologous tumor antigens. Based on our prior genome-wi
Publikováno v:
Cancer Immunology Research. 4:B142-B142
Exhaustion of CD8+ T lymphocytes is a major barrier to effective clearance of chronic viral infection and cancer by the immune system. Transcriptional changes underlie the expansion and differentiation of a naive CD8+ T cell into various effector sub
Publikováno v:
Cancer immunology, immunotherapy : CII. 62(12)
Identification of novel vaccine targets is critical for the design and advancement of prostate cancer (PCa) immunotherapy. Ideal targets are proteins that are abundant in prostate tumors while absent in extra-prostatic tissues. The fusion of the andr
Publikováno v:
Qatar Foundation Annual Research Forum Volume 2012 Issue 1.
Background: The recent approval by the FDA of the autologous, cell-based vaccine Provenge was hailed as a major advance for the treatment of advanced prostate cancer (PCa) and reinvigorated interest in the field of PCa immunotherapy. Peptide-based va
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 30(11)
We have reported previously that a combined intratumoral treatment with anti-CD25mAb/transforming growth factor-β (TGF-β) soluble receptor induced regression of established and subcutaneous AE17 murine mesotheliomas. Here, we have investigated the
Autor:
Haydn T. Kissick, Demelza J. Ireland, Peter J. Heenan, Christine F. Carson, Sara J. Greay, Thomas V. Riley, Manfred W. Beilharz
Publikováno v:
Cancer chemotherapy and pharmacology. 66(6)
Systemic toxicity coupled with long treatment regimes of approved topical chemotherapeutic agents such as imiquimod and 5-fluorouracil (5-FU) are limiting. There is now more focus on the potential use of topical terpene agents as skin cancer treatmen
Autor:
Christine F. Carson, Sara J. Greay, Thomas V. Riley, Manfred W. Beilharz, Haydn T. Kissick, Demelza J. Ireland, Avram Levy
Publikováno v:
Cancer chemotherapy and pharmacology. 65(5)
To examine the in vitro anticancer activity of Melaleuca alternifolia (tea tree) oil (TTO), and its major active terpene component, terpinen-4-ol, against two aggressive murine tumour cell lines, AE17 mesothelioma and B16 melanoma. Effects of TTO and
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 29(4)
Suppression of an anti-tumor immune response by regulatory T cells (T(regs)) in tumor-bearing hosts is now well established. Previously, we have reported that the intratumoral administration of T(reg)-depleting anti-CD25 monoclonal antibody every 10
Autor:
Adeboya O. Osunkoya, Haydn T. Kissick, Kenneth Ogan, Brian Pollack, Viraj A. Master, Dattatraya Patil, Claire de la Calle, Jonathan Huang, Sarah A. Holzman, Umer Sheikh
Publikováno v:
Journal of Clinical Oncology. 33:469-469
469 Background: After nephrectomy for clear cell renal cell carcinoma (ccRCC) approximately one-third of patients develop metastases. Yet, with currently used prognostic tools such as the TNM staging and the Fuhrman nuclear grade (FNG) system, it is