Zobrazeno 31 - 40
of 96
pro vyhledávání: '"Hariharan Easwaran"'
Autor:
Daria A. Gaykalova, Rossin Erbe, Elana J. Fertig, Michael D. Kessler, Hariharan Easwaran, ler, Alexander V. Favorov
Publikováno v:
Nucleic Acids Research
While the methods available for single-cell ATAC-seq analysis are well optimized for clustering cell types, the question of how to integrate multiple scATAC-seq data sets and/or sequencing modalities is still open. We present an analysis framework th
Autor:
Sharon Wu, Elizabeth M. Jaffee, Joanne Xiu, Evanthia T. Roussos Torres, Jerry Lee, Ashani T. Weeraratna, Claudine Isaacs, Michael J. Topper, Jennifer La, Ilya G. Serebriiskii, Igor Astsaturov, Reva Basho, Rossin Erbe, Marc E. Lippman, Elana J. Fertig, Nathanael Fillmore, Hariharan Easwaran, Zheyu Wang, Nicolas A. Giraldo, John Marshall, Josephine A. Taverna, Neeha Zaidi, David Tuck, Stephen B. Baylin, Heinz-Josef Lenz
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110033-(2021)
Cell reports
Cell Reports, Vol 36, Iss 8, Pp 109599-(2021)
Cell reports
Cell Reports, Vol 36, Iss 8, Pp 109599-(2021)
SUMMARY Both tumors and aging alter the immune landscape of tissues. These interactions may play an important role in tumor progression among elderly patients and may suggest considerations for patient care. We leverage large-scale genomic and clinic
Autor:
Steve Baylin, Hariharan Easwaran, Vinod Krishna, Kurtis E. Bachman, Sehej Parmar, Yuba R. Bhandari, Rachael Powers
Publikováno v:
Cancer Research. 81:2107-2107
Colorectal cancer (CRC) is classified into distinct subtypes based on genetic, epigenetic and/or transcriptional subtypes. The underlying mechanisms that drive these subtypes are unknown. By integrating whole genome DNA methylation, gene expression,
Autor:
Claudine Isaacs, Neeha Zaidi, Elizabeth M. Jaffee, Evanthia T. Roussos Torres, Zheyu Wang, Elana J. Fertig, Joanne Xiu, Reva Basho, Igor Astsaturov, Hariharan Easwaran, Rossin Erbe, Ashani T. Weeraratna, Heinz-Josef Lenz, Sharon Wu, Stephen B. Baylin, Marc E. Lippman, John L. Marshall
Publikováno v:
Journal of Clinical Oncology. 39:2543-2543
2543 Background: Immune checkpoint blockade (ICB) immunotherapy in some cases elicits striking patient responses, but its efficacy appears to be dependent on several incompletely understood factors. Most studies of ICB therapies in elderly patients h
Autor:
Nilofer S. Azad, Stephen B. Baylin, Joel Picus, Charles Erlichman, Ross C. Donehower, Ann L. Oberg, Peter W. Laird, Patrick J. Flynn, Prakriti Medvari, Hariharan Easwaran, Anthony B. El-Khoueiry, Nathan Bahary, Ihab R. Kamel, Thomas M. Brown, Daniel J. Weisenberger, Jun Yin, Peter A. Jones, Hui Shen, Anup Sharma, Henry C. Pitot, George P. Kim, Nita Ahuja, Douglas Adkins, Richard Piekarz
Publikováno v:
Oncotarget
// Nilofer S. Azad 1 , Anthony el-Khoueiry 2 , Jun Yin 3 , Ann L. Oberg 3 , Patrick Flynn 4 , Douglas Adkins 5 , Anup Sharma 1 , Daniel J. Weisenberger 2 , Thomas Brown 1 , Prakriti Medvari 1 , Peter A. Jones 6 , Hariharan Easwaran 1 , Ihab Kamel 1 ,
Autor:
Yang W. Zhang, Wenbing Xie, Ray Whay Chiu Yen, Hariharan Easwaran, Limin Xia, Yana Li, Zhihong Wang, Yi Cai, Jianjun Luo, Stephen B. Baylin
Publikováno v:
Molecular Cell. 65:323-335
TET proteins, by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are hypothesized, but not directly shown, to protect promoter CpG islands (CGIs) against abnormal DNA methylation (DNAm) in cancer. We define such a protective role
Autor:
Michael J. Topper, Daiming Fan, Wenbing Xie, Cynthia A. Zahnow, Jie Chen, Xiangqian Kong, Ray Whay Chiu Yen, Rochelle L. Tiedemann, Srinivasan Yegnasubramanian, Hariharan Easwaran, Stephen M. Brown, Scott B. Rothbart, Limin Xia, Kaichun Wu, Stephen B. Baylin, Yongzhan Nie, Yi Cai, Yong Tao
Summary UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in mammalian cells. The establishment domains are defined, including E3 ligase function, but the maintenance domains are poorly characterized. Here, we demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dee4b5f1f9d3c33da218a9d21597800
https://europepmc.org/articles/PMC6521721/
https://europepmc.org/articles/PMC6521721/
Autor:
Miguel A. Peinado, Xiangqian Kong, Shinji Maegawa, Nicholas C. Zachos, Yong Tao, Yuba R. Bhandari, Byunghak Kang, Elana J. Fertig, Jean Pierre J. Issa, Yi Cai, Wenbing Xie, Stephen B. Baylin, Daniel A. Petkovich, Izaskun Mallona, Genevieve Stein-O’Brien, Ray Whay Chiu Yen, Yuezheng Zhang, Hariharan Easwaran, Nita Ahuja, Stephen M. Brown, Cynthia A. Zahnow, Xiaojian Shao, Jai Thakor, Himani Vaidya, Zhihao Lu, Julie In
Publikováno v:
Cancer Cell
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
We addressed the precursor role of aging-like spontaneous promoter DNA hypermethylation in initiating tumorigenesis. Using mouse colon-derived organoids, we show that promoter hypermethylation spontaneously arises in cells mimicking the human aging-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726d795dd960279d63396d9c2016bc01
https://europepmc.org/articles/PMC6636642/
https://europepmc.org/articles/PMC6636642/
Autor:
Zhihao, Lu, Jianling, Zou, Shuang, Li, Michael J, Topper, Yong, Tao, Hao, Zhang, Xi, Jiao, Wenbing, Xie, Xiangqian, Kong, Michelle, Vaz, Huili, Li, Yi, Cai, Limin, Xia, Peng, Huang, Kristen, Rodgers, Beverly, Lee, Joanne B, Riemer, Chi-Ping, Day, Ray-Whay Chiu, Yen, Ying, Cui, Yujiao, Wang, Yanni, Wang, Weiqiang, Zhang, Hariharan, Easwaran, Alicia, Hulbert, KiBem, Kim, Rosalyn A, Juergens, Stephen C, Yang, Richard J, Battafarano, Errol L, Bush, Stephen R, Broderick, Stephen M, Cattaneo, Julie R, Brahmer, Charles M, Rudin, John, Wrangle, Yuping, Mei, Young J, Kim, Bin, Zhang, Ken Kang-Hsin, Wang, Patrick M, Forde, Joseph B, Margolick, Barry D, Nelkin, Cynthia A, Zahnow, Drew M, Pardoll, Franck, Housseau, Stephen B, Baylin, Lin, Shen, Malcolm V, Brock
Publikováno v:
Nature. 579(7798)
Cancer recurrence after surgery remains an unresolved clinical problem
Autor:
Hariharan Easwaran, Stephen B. Baylin
Publikováno v:
RNA Technologies ISBN: 9783030147914
DNA methylation is a key epigenetic mark in the heritable regulation of gene expression, with important roles in normal development and disease. Genomewide alterations in DNA methylation patterns are universal feature across cancers. Studies in the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d02ffe5617a20f976c86d6b371e80c2
https://doi.org/10.1007/978-3-030-14792-1_2
https://doi.org/10.1007/978-3-030-14792-1_2