Zobrazeno 21 - 30
of 30
pro vyhledávání: '"Gwendolyn Binder-Scholl"'
Autor:
Sandra P. D'Angelo, Gwendolyn Binder-Scholl, Kunle Odunsi, Melinda S. Merchant, Edward A. Stadtmauer, Stephan A. Grupp, Bent K. Jakobsen, Mihaela C. Cristea, Aaron P. Rapoport, Tom Holdich, Crystal L. Mackall, William D. Tap
Publikováno v:
Journal of Clinical Oncology. 33:TPS3102-TPS3102
TPS3102 Background: NY-ESO-1 (CTAG-1B) is a cancer testis antigen associated with spontaneous and vaccine-induced immunity that can lead to improved clinical outcomes. NY-ESO-1 is not expressed in vital tissues, and is expressed in approximately 40%
Autor:
Luca Melchiori, On Kan, Gwendolyn Binder-Scholl, Bent K. Jakobsen, Daniel Williams, David Moss, Martin Kreutz
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts Engineered T cell therapy (ECT) for oncology has met significant clinical proof of success for chemotherapy resistant B cell malignancies in multiple studies. These data have underscored the transformative potential of ECT in advanc
Autor:
Ashraf Badros, Gwendolyn Binder-Scholl, Naseem Kerr, Michael Kalos, Dan T. Vogl, Edward A. Stadtmauer, Bent K. Jakobsen, Jeffrey Finklestein, Dominic P. Smethurst, Bruce L. Levine, Lilliam Ribeiro, Joanna E. Brewer, Sandra Westphal, Aaron P. Rapoport, Brendan M. Weiss, Gorgun Akpek, Minnal Gupta, Carl H. June, Saul Yanovich, Irina Kulikovskaya, Sunita Philip, Helen K. Tayton-Martin, Alan D. Bennett, Nicholas J. Pumphrey, Andrew B. Gerry
Publikováno v:
Blood. 122:766-766
Background Despite recent therapeutic advances, multiple myeloma (MM) remains primarily an incurable cancer. Patients experiencing rapid recovery of T cells post autologous stem cell transplant (auto-SCT) may have improved outcomes, and spontaneous c
Autor:
Sunita Philip, Karen Dengel, Minnal Gupta, Alan D. Bennett, Tatiana Mikheeva, Carl H. June, Helen K. Tayton-Martin, Edward A. Stadtmauer, Bent K. Jakobsen, Jeffrey Finkelstein, Andrew B. Gerry, Ashraf Z. Bados, Lilliam Ribeiro, Joanna E. Brewer, Dan T. Vogl, Elizabeth Veloso, Bruce L. Levine, Saul Yanovich, Zhaohui Zheng, Gorgun Akpek, Kelly-Marie Betts, Irina Kulikovskaya, Gwendolyn Binder-Scholl, Erica Suppa, Naseem Kerr, Michael Kalos, Sandra Westphal, Aaron P. Rapoport, Brendan M. Weiss, Dominic P. Smethurst, Nick Pumphrey
Publikováno v:
Cancer Research. 73:4575-4575
Background: Adoptive immunotherapy for cancer has been limited by lack of antigen specificity, low levels of target expression, and failure to break self-tolerance. We are conducting an early phase clinical trial (NCT01352286) attempting to overcome
Autor:
Ashraf Badros, Gorgun Akpek, Gwendolyn Binder-Scholl, Alan D. Bennett, Helen K. Tayton-Martin, Carl H. June, Michael Kalos, Joanna E. Brewer, Elizabeth Veloso, Edward A. Stadtmauer, Zhaohui Zheng, Bruce L. Levine, Bent K. Jakobsen, Saul Yanovich, Timothy L. Macatee, Dominic P. Smethurst, Holly McConville, Sunita Philip, Andrew B. Gerry, Nick Pumphrey, Dan T. Vogl, Jeffrey Finklestein, Aaron P. Rapoport, Brendan M. Weiss, Minnal Gupta, Irina Kulikovskaya
Publikováno v:
Blood. 120:755-755
Abstract 755 Background: Adoptive transfer of T cells genetically engineered to express affinity-enhanced T cell receptors (TcRs) specific for self-antigens is one approach to generate potent anti-tumor immunity, and this approach is being evaluated
Autor:
Sandra Westphal, Aaron P. Rapoport, Brendan M. Weiss, Sunita Philip, Gwendolyn Binder-Scholl, Helen K. Tayton-Martin, Ribeiro C. Lilliam, Joanna E. Brewer, Naseem Kerr, Ashraf Badros, Dan T. Vogl, Michael Kalos, Dominic P. Smethurst, Alan D. Bennett, Edward A. Stadtmauer, Elizabeth Veloso, Gorgun Akpek, Zhaohui Zheng, Bent K. Jakobsen, Carl H. June, Bruce L. Levine, Nick Pumphrey, Andrew B. Gerry, Holly McConville, Saul Yanovich, Kelly-Marie Betts
Publikováno v:
Blood. 120:472-472
Abstract 472 Background: Despite recent therapeutic advances, multiple myeloma (MM) remains primarily an incurable cancer. Patients experiencing rapid recovery of T cells post auto-SCT may have improved outcomes, and spontaneous cellular responses to
Autor:
Yoav Peretz, Bent K. Jakobsen, Hua Zhang, Gwendolyn Binder-Scholl, Luca Melchiori, Tom Holdich, Rafael G. Amado, Marylène Fortin, William D. Tap, Matthew Wright, Lini Pandite, Paul A. Meyers, Crystal L. Mackall, Sandra P. D'Angelo, Melinda S. Merchant
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts Relapsed or metastatic synovial sarcoma remains a significant unmet medical need. NY-ESO-1 is an attractive target for sarcoma, since it is expressed in approximately 70% of synovial sarcomas but not on vital tissues. We generated N
Autor:
Bent K. Jakobsen, Carl H. June, Edward A. Stadtmauer, Dominic P. Smethurst, Joshua P. Cantor, Lilliam Ribeiro, Bruce L. Levine, Emma E. Furth, Alfred L. Garfall, Gwendolyn Binder-Scholl, Michael Kalos, Aaron P. Rapoport, Brendan M. Weiss, Minnal Gupta, Dan T. Vogl
Publikováno v:
Biology of Blood and Marrow Transplantation. (2):S134
Autor:
Eduardo Davila, Luca Melchiori, Rafael G. Amado, Bent K. Jakobsen, Gwendolyn Binder-Scholl, Aaron P. Rapoport, Ryan Wong
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts It is now well established that human tumors express unique antigens, however tumor immune evasion mechanisms often prevent effective naturally occurring anti-tumor immune responses. We hypothesized that infusion of T cells that hav
Autor:
Ashraf Badros, Edward A. Stadtmauer, Alan D. Bennett, Andrew B. Gerry, Sunita Philip, Levine L Bruce, Dominic P. Smethurst, Carl H. June, Lilliam Ribeiro, Joanna E. Brewer, Helen K. Tayton-Martin, Dan T. Vogl, Gorgun Akpek, Bent K. Jakobsen, Saul Yanovich, Sandra Westphal, Aaron P. Rapoport, Brendan M. Weiss, Gwendolyn Binder-Scholl, Naseem Kerr, Michael Kalos, Jeffrey Finklestein, Irina Kulikovskaya, Minnal Gupta, Nick Pumphrey
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts We report on a 26 patient phase I/II clinical trial ([NCT01352286][1]) to investigate the safety, feasibility and anti-tumor activity of T cells engineered to express an affinity-enhanced TCR that recognizes the NY-ESO-1/LAGE-1 pept
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