Zobrazeno 21 - 30
of 135
pro vyhledávání: '"Geoffroy Andrieux"'
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The manifestations of cancerous phenotypes necessitate alterations at different levels of information-flow from genome to proteome. The molecular alterations at different information processing levels serve as the basis for the cancer phenotype to em
Externí odkaz:
https://doaj.org/article/2681f963d49249019cb09d5c29712e9b
Autor:
Ina Harder, Matthias Münchhalfen, Geoffroy Andrieux, Melanie Boerries, Bodo Grimbacher, Hermann Eibel, Maria Elena Maccari, Stephan Ehl, Jürgen Wienands, Julia Jellusova, Klaus Warnatz, Baerbel Keller
Publikováno v:
Cells, Vol 11, Iss 3, p 464 (2022)
The altered wiring of signaling pathways downstream of antigen receptors of T and B cells contributes to the dysregulation of the adaptive immune system, potentially causing immunodeficiency and autoimmunity. In humans, the investigation of such comp
Externí odkaz:
https://doaj.org/article/dd082ffbb1aa4bcf9d83fc42ce3f9a42
Autor:
Felix Kind, Thomas F. Fassbender, Geoffroy Andrieux, Melanie Boerries, Philipp T. Meyer, Juri Ruf
Publikováno v:
Cancers, Vol 14, Iss 1, p 149 (2021)
Purpose: Radioligand therapy with [177Lu]PSMA-617 (PSMA-RLT) is a promising therapeutic option for metastatic castration-resistant prostate cancer (mCPRP). This study assessed the prognostic value of early PSA measurements during PSMA-RLT. Methods: 2
Externí odkaz:
https://doaj.org/article/d0665583f1894857bcc7af53c82158dc
Autor:
Eileen Haring, Franziska M. Uhl, Geoffroy Andrieux, Michele Proietti, Alla Bulashevska, Barbara Sauer, Lukas M. Braun, Enrique de Vega Gomez, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Marie Follo, Annette Schmitt-Graeff, Joerg Buescher, Justus Duyster, Bodo Grimbacher, Melanie Boerries, Erika L. Pearce, Robert Zeiser, Petya Apostolova
Publikováno v:
Haematologica, Vol 106, Iss 8 (2020)
Acute graft-versus-host disease causes significant mortality in patients undergoing allogeneic hematopoietic cell transplantation. Immunosuppressive treatment for graft-versus-host disease can impair the beneficial graft-versus-leukemia effect and fa
Externí odkaz:
https://doaj.org/article/63bfd079d0904bb389c7f5bf30a08018
Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures.
Autor:
Dirk Schumacher, Geoffroy Andrieux, Karsten Boehnke, Marlen Keil, Alessandra Silvestri, Maxine Silvestrov, Ulrich Keilholz, Johannes Haybaeck, Gerrit Erdmann, Christoph Sachse, Markus Templin, Jens Hoffmann, Melanie Boerries, Reinhold Schäfer, Christian R A Regenbrecht
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008076 (2019)
Organoid cultures derived from colorectal cancer (CRC) samples are increasingly used as preclinical models for studying tumor biology and the effects of targeted therapies under conditions capturing in vitro the genetic make-up of heterogeneous and e
Externí odkaz:
https://doaj.org/article/4a7ae2e6be5340cd9102d8eb799ab595
Autor:
Christoph Bauer, Meret Quante, Willemijn B. Breunis, Carla Regina, Michaela Schneider, Geoffroy Andrieux, Oliver Gorka, Olaf Groß, Melanie Boerries, Bernd Kammerer, Simone Hettmer
Publikováno v:
Cancers, Vol 13, Iss 3, p 412 (2021)
Amino acids are integral components of cancer metabolism. The non-essential amino acid asparagine supports the growth and survival of various cancer cell types. Here, different mass spectrometry approaches were employed to identify lower aspartate le
Externí odkaz:
https://doaj.org/article/c249bd9822f3450a8c71c5a7ff1364ae
Autor:
Patrick Frey, Antoine Devisme, Monika Schrempp, Geoffroy Andrieux, Melanie Boerries, Andreas Hecht
Publikováno v:
Cancers, Vol 12, Iss 4, p 1019 (2020)
Epithelial-mesenchymal transition (EMT) is a pivotal process in development and disease. In carcinogenesis, various signaling pathways are known to trigger EMT by inducing the expression of EMT transcription factors (EMT-TFs) like SNAIL1, ultimately
Externí odkaz:
https://doaj.org/article/de457fc092db493aa2d0c7c35f2e26d5
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33761 (2012)
TIF1γ (Transcriptional Intermediary Factor 1 γ) has been implicated in Smad-dependent signaling by Transforming Growth Factor beta (TGF-β). Paradoxically, TIF1γ functions both as a transcriptional repressor or as an alternative transcription fact
Externí odkaz:
https://doaj.org/article/a60aac4bd0944f2e973767004d21009c
Autor:
Katrin Raute, Juliane Strietz, Maria Alejandra Parigiani, Geoffroy Andrieux, Oliver S. Thomas, Klaus M. Kistner, Marina Zintchenko, Peter Aichele, Maike Hofmann, Houjiang Zhou, Wilfried Weber, Melanie Boerries, Mahima Swamy, Jochen Maurer, Susana Minguet
Publikováno v:
Cancer Immunology Research. :OF1-OF20
There are no targeted therapies for patients with triple-negative breast cancer (TNBC). TNBC is enriched in breast cancer stem cells (BCSC), which play a key role in metastasis, chemoresistance, relapse, and mortality. γδ T cells hold great potenti
Autor:
Marlene Langenbach, Sophie Giesler, Stefan Richtsfeld, Sara Costa-Pereira, Lukas Rindlisbacher, Tobias Wertheimer, Lukas M. Braun, Geoffroy Andrieux, Sandra Duquesne, Dietmar Pfeifer, Nadine M. Woessner, Hans D. Menssen, Sanaz Taromi, Justus Duyster, Melanie Börries, Tilman Brummer, Bruce R. Blazar, Susana Minguet, Patrick Turko, Mitchell P. Levesque, Burkhard Becher, Robert Zeiser
Publikováno v:
Molecular Cancer Research. :OF1-OF16
The treatment of patients with metastatic melanoma with immune checkpoint inhibitors (ICI) leads to impressive response rates but primary and secondary resistance to ICI reduces progression-free survival. Novel strategies that interfere with resistan