Zobrazeno 71 - 80
of 116
pro vyhledávání: '"Geert J. P. L. Kops"'
Autor:
Geert J. P. L. Kops, Tale Sliedrecht, Tim A. Hoek, Manja Omerzu, Eelco C. Tromer, Vincent Groenewold, Mathijs Vleugel
Publikováno v:
Journal of Cell Science.
Mitotic chromosome segregation is initiated by the anaphase promoting complex/cyclosome (APC/C) and its co-activator CDC20 (forming APC/CCDC20). APC/CCDC20 is inhibited by the spindle assembly checkpoint (SAC) when chromosomes have not attached to sp
Publikováno v:
Nature Communications
Nature Communications, 6. Nature Publishing Group
Nature Communications [E], 6. Nature Publishing Group
Nature Communications, 6. Nature Publishing Group
Nature Communications [E], 6. Nature Publishing Group
The spindle assembly checkpoint (SAC) is a genome surveillance mechanism that protects against aneuploidization. Despite profound progress on understanding mechanisms of its activation, it remains unknown what aspect of chromosome–spindle interacti
Autor:
Yoshitaka, Hiruma, Carlos, Sacristan, Spyridon T, Pachis, Athanassios, Adamopoulos, Timo, Kuijt, Marcellus, Ubbink, Eleonore, von Castelmur, Anastassis, Perrakis, Geert J P L, Kops
Publikováno v:
Science (New York, N.Y.). 348(6240)
Cell division progresses to anaphase only after all chromosomes are connected to spindle microtubules through kinetochores and the spindle assembly checkpoint (SAC) is satisfied. We show that the amino-terminal localization module of the SAC protein
Autor:
Nannette Jelluma, Geert J. P. L. Kops
Publikováno v:
Cancer discovery. 4(11)
Summary: Chromosome segregation errors and DNA damage are in a vicious cycle in cancer cells. Bakhoum and colleagues show that the molecular response to damaged DNA during mitosis impairs the chromosome segregation machinery, adding a new level to th
Publikováno v:
Nature Reviews Cancer. 5:773-785
Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards agains
Autor:
Don W. Cleveland, Beth A. Weaver, Yinghui Mao, Mitsuo Tagaya, John R. Yates, Ian McLeod, Yumi Kim, Geert J. P. L. Kops
Publikováno v:
The Journal of Cell Biology
The mitotic checkpoint ensures that chromosomes are divided equally between daughter cells and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tumors. ZW10 and Rod play an essential role in this checkpoint.
Publikováno v:
Proceedings of the National Academy of Sciences. 101:8699-8704
A compromised mitotic checkpoint, the primary mechanism for ensuring that each new cell receives one copy of every chromosome, has been implicated as a contributor to carcinogenesis. However, a checkpoint response is shown here to be essential for ce
Autor:
Johannes L. Bos, Nannette Jelluma, Karel W. A. Wirtz, Tobias B. Dansen, Ronald J.A. Wanders, Geert J. P. L. Kops, Simone Denis, Boudewijn M.T. Burgering
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 1, Pp 81-88 (2004)
Journal of lipid research, 45(1), 81-88. American Society for Biochemistry and Molecular Biology Inc.
Journal of lipid research, 45(1), 81-88. American Society for Biochemistry and Molecular Biology Inc.
The SCP gene encodes two proteins, sterol carrier protein X (SCPx) and SCP2, that are independently regulated by separate promoters. SCPx has been shown to be the thiolase involved in the breakdown of branched-chain fatty acids and in the biosynthesi
Autor:
Don W. Cleveland, Alain D. Silk, Zahid Q. Bonday, Frances R. Putkey, Geert J. P. L. Kops, Beth A. Weaver
Publikováno v:
The Journal of cell biology, vol 162, iss 4
The Journal of Cell Biology
The Journal of Cell Biology
Centromere-associated protein-E (CENP-E) is an essential mitotic kinesin that is required for efficient, stable microtubule capture at kinetochores. It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint
Autor:
Tobias B. Dansen, Karel W. A. Wirtz, Boudewijn M.T. Burgering, Johannes L. Bos, Paul J. Coffer, Ingrid Saarloos, Geert J. P. L. Kops, Paulien E. Polderman, Ting-T. Huang, René H. Medema
Publikováno v:
Nature. 419:316-321
Reactive oxygen species are required for cell proliferation but can also induce apoptosis1. In proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also known as c-Akt), which protects cells from apoptosis2. By contr